Climbing Fiber Burst Size and Olivary Sub-threshold Oscillations in a Network Setting [PDF]
PLoS Computational Biology, 2012 The inferior olivary nucleus provides one of the two main inputs to the cerebellum: the so-called climbing fibers. Activation of climbing fibers is generally believed to be related to timing of motor commands and/or motor learning.
A Badura +41 more
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PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. [PDF]
Front Mol Neurosci, 2023 Functionally mature neural circuits are shaped during postnatal development by eliminating redundant synapses formed during the perinatal period. In the cerebellum of neonatal rodents, each Purkinje cell (PC) receives synaptic inputs from multiple (more ...
Okuno Y +7 more
europepmc +2 more sources
Climbing Fiber Regulation of Spontaneous Purkinje Cell Activity and Cerebellum-Dependent Blink Responses(1,2,3). [PDF]
eNeuro, 2016 It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active.
Zucca R, Rasmussen A, Bengtsson F.
europepmc +5 more sources
Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. [PDF]
Elife, 2019 The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression.
Tsutsumi S +6 more
europepmc +2 more sources
Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning. [PDF]
PLoS Comput BiolAlthough the cerebellum is typically associated with supervised learning algorithms, it also exhibits extensive involvement in reward processing. In this study, we investigated the cerebellum's role in executing reinforcement learning algorithms, with a ...
Hoang H +6 more
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Communications Biology, 2023 Cerebellar climbing fibers convey sensorimotor information and their errors, which are used for motor control and learning. Furthermore, they represent reward-related information.
Koji Ikezoe +7 more
doaj +1 more source
Supervised learning with complex spikes and spike-timing-dependent plasticity. [PDF]
PLoS ONE, 2014 One distinctive feature of Purkinje cells is that they have two types of discharge: in addition to simple spikes they fire complex spikes in response to input from the climbing fibers.
Conor Houghton
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Frontiers in Cellular Neuroscience, 2023 Cyfip1, the gene encoding cytoplasmic FMR1 interacting protein 1, has been of interest as an autism candidate gene for years. A potential role in autism spectrum disorder (ASD) is suggested by its location on human chromosome 15q11-13, an instable region
Silas E. Busch +8 more
doaj +1 more source
Widespread state-dependent shifts in cerebellar activity in locomoting mice. [PDF]
PLoS ONE, 2012 Excitatory drive enters the cerebellum via mossy fibers, which activate granule cells, and climbing fibers, which activate Purkinje cell dendrites.
Ilker Ozden +4 more
doaj +1 more source
Stairway to heaven: evaluating levels of biological organization correlated with the successful ascent of natural waterfalls in the Hawaiian stream goby Sicyopterus stimpsoni. [PDF]
PLoS ONE, 2013 Selective pressures generated by locomotor challenges act at the level of the individual. However, phenotypic variation among individuals that might convey a selective advantage may occur across any of multiple levels of biological organization.
Heiko L Schoenfuss +5 more
doaj +1 more source