Results 91 to 100 of about 42,190 (304)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells

Cell Reports, 2015
Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories.
Séverine M. Sigoillot, Keerthana Iyer, Francesca Binda, Inés González-Calvo, Maëva Talleur, Guilan Vodjdani, Philippe Isope, Fekrije Selimi   +7 more
doaj   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing

Cell Reports, 2018
Summary: Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning.
Derek L.F. Garden, Marlies Oostland, Marta Jelitai, Arianna Rinaldi, Ian Duguid, Matthew F. Nolan   +5 more
doaj   +1 more source

Local Thermal Conductivity Patterning in Rotating Lattice Crystals of Anisotropic Sb2S3

Advanced Functional Materials, EarlyView.
Microscale control of thermal conductivity in Sb2S3 is demonstrated via laser‐induced rotating lattice crystals. Thermal conductivity imaging reveals marked thermal transport anisotropy, with the c axis featuring amorphous‐like transport, whereas in‐plane directions (a, b) exhibit 3.5x and 1.7x larger thermal conductivity.
Eleonora Isotta, Rosemary Wynnychenko, Binayak Mukherjee, Jack Kaman, Hrushikesh Sahasrabuddhe, Jiongzhi Zheng, Anubhav Jain, Geoffroy Hautier, Alexandra Zevalkink, Evan Musterman, Volkmar Dierolf, Himanshu Jain, G. Jeffrey Snyder, Oluwaseyi Balogun   +13 more
wiley   +1 more source

A mobile planetary lander utilizing elastic loop suspension [PDF]

, 1976
Efforts to increase the cost effectiveness of future lunar and planetary rover missions have led to the mobile lander concept, which replaces the landing legs of a soft-lander craft with a compact mobility system of sufficient strength to withstand the ...
Trautwein, W.
core   +1 more source

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A consensus paper [PDF]

, 2017
For many decades the predominant view in the cerebellar field has been that theolivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse.
Apps, Richard, Bengtsson, Fredrik, Cerminara, Nadia, De Zeeuw, C. I., Ebner, Timothy J., Heck, Detlef H., Jaeger, Dieter, Lang, Eric J., Otis, Thomas S., Reeves, Alexander M. B., Schweighofer, Nicolas   +10 more
core   +2 more sources

Maya Blue‐Inspired Hybrid Coating for Robust and Superhydrophilic Solar Evaporators Using Commercial Black Acrylic Paint

Advanced Functional Materials, EarlyView.
This study demonstrates a Maya blue‐inspired hybrid solar evaporator using commercial black acrylic paint, achieving 98% solar‐thermal conversion efficiency and 2.39 kg m−2 h−1 water evaporation rate through a durable, hydrophilic organic–inorganic structure that enables scalable, cost‐effective desalination and wastewater purification.
Dao Thi Dung, Do Van Lam, Young Kim, Wonzee Jung, Kanghoon Yim, Seung‐Mo Lee   +5 more
wiley   +1 more source

Cerebellar encoding of multiple candidate error cues in the service of motor learning [PDF]

, 2014
or learning to occur through trial and error, the nervous system must effectively detect and encode performance errors. To examine this process, we designed a set of oculomotor learning tasks with more than one visual object providing potential error ...
Guo, Christine C., Ke, Michael C., Raymond, Jennifer L.   +2 more
core   +1 more source

Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

eLife, 2019
Classical models of cerebellar learning posit that climbing fibers operate according to a supervised learning rule to instruct changes in motor output by signaling the occurrence of movement errors.
William Heffley, Court Hull
doaj   +1 more source