Results 11 to 20 of about 42,190 (304)
Climbing fiber signaling and cerebellar gain control [PDF]
Frontiers in Cellular Neuroscience, 2009 The physiology of climbing fiber signals in cerebellar Purkinje cells has been studied since the early days of electrophysiology. Both the climbing fiber-evoked complex spike and the role of climbing fiber activity in the induction of long-term ...
Gen Ohtsuki +4 more
doaj +4 more sources
Droplets climbing a rotating helical fiber [PDF]
The European Physical Journal E, 2015 A liquid droplet is placed on a rotating helical fiber. We find that the droplet may slide down, attach or climb up the fiber. We inspect experimentally the domain of existence of these three behaviors as a function of the geometrical characteristics of ...
Dorbolo, Stéphane +1 more
core +6 more sources
Cerebellar climbing fibers encode expected reward size
eLife, 2019 Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward.
Noga Larry +3 more
doaj +3 more sources
Climbing Fibers Provide Graded Error Signals in Cerebellar Learning [PDF]
Frontiers in Systems Neuroscience, 2019 The cerebellum plays a critical role in coordinating and learning complex movements. Although its importance has been well recognized, the mechanisms of learning remain hotly debated.
Yunliang Zang, Erik De Schutter
doaj +3 more sources
Current concepts of climbing fiber function [PDF]
The Anatomical Record, 1998 This review examines several of the current postulates regarding the function of one of the most intriguing afferent systems in the brain, the climbing fiber system. The fact that these afferents are activated under a variety of conditions has contributed substantially to the diversity of postulates that have been proposed.
J R, Bloedel, V, Bracha
openaire +2 more sources
How do climbing fibers teach? [PDF]
Frontiers in Neural Circuits, 2012 A commentary on A theory of cerebellar cortex by Marr, D. (1969). J. Physiol. 202, 437–470. A commentary on A theory of cerebellar function by Albus, J. S. (1971). Math. Biosci. 10, 25–61. Four decades ago, Marr and Albus suggested that the climbing fiber (CF) pathway from the inferior olive (IO) to the cerebellum instructs the ...
Otis, Thomas S. +3 more
openaire +3 more sources
Intraburst and Interburst Signaling by Climbing Fibers [PDF]
The Journal of Neuroscience, 2007 Although cerebellar Purkinje cell complex spikes occur at low frequency (∼1/s), each complex spike is often associated with a high-frequency burst (∼500/s) of climbing fiber spikes. We examined the possibility that signals are present within the climbing fiber bursts.
Jun, Maruta +2 more
openaire +2 more sources
Bidirectional Parallel Fiber Plasticity in the Cerebellum under Climbing Fiber Control [PDF]
Neuron, 2004 Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or not the climbing fiber (CF) input is coactivated during tetanization. Here, we show that modifications of the postsynaptic calcium load using the calcium chelator BAPTA or ...
Coesmans, Michiel +3 more
openaire +2 more sources
Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements
eLife, 2018 Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs).
Michael A Gaffield +4 more
doaj +1 more source
Afferent convergence to a shared population of interneuron AMPA receptors
Nature Communications, 2023 Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission ...
Reagan L. Pennock +4 more
doaj +1 more source