Results 41 to 50 of about 42,190 (304)

Geochemical support for a climbing habit within the Paleozoic seed fern genus Medullosa [PDF]

, 2011
A long-standing problem in paleobotany is the accurate identification of the growth habits and statures of fossil plants. Tissue-specific analysis of stable carbon isotope ratios in plant fossils can provide an independent perspective on this issue ...
Fischer, Woodward W., Wilson, Jonathan P.   +1 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cerebellar nuclei neurons show only small excitatory responses to optogenetic olivary stimulation in transgenic mice: in vivo and in vitro studies

Frontiers in Neural Circuits, 2016
To study the olivary input to the cerebellar nuclei (CN) we used optogenetic stimulation in transgenic mice expressing channelrhodopsin-2 (ChR2) in olivary neurons.
Huo eLu, Huo eLu, Bo eYang, Dieter eJaeger   +3 more
doaj   +1 more source

Evaluation of a climbing drum laminate peel test to determine the interlaminar mode I fracture toughness of thin CFRP laminates—Comparison with the standard mode I DCB test and a mandrel laminate peel test proposed by ESIS TC4

Frontiers in Materials, 2023
A recently proposed mandrel laminate peel (MLP) test for quantification of delamination propagation in Fiber-Reinforced Polymer (FRP) composites is compared with a climbing drum laminate peel (CDLP) test, and the standard quasi-static Mode I fracture ...
Silvain Michel, Fabian Hauf, Andreas J. Brunner   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Marr and Albus Theories of the Cerebellum: Two Eary Models of Associative Memory [PDF]

, 1989
The Marr and Albus theories of the cerebellum are compared and contrasted. They are shown to be similar in their analysis of the function of the mossy fibers, granule cells, Golgi cells, and Purkinje cells.
Albus, James S.
core   +1 more source

A Neural Model of Timed Response Learning in the Cerebellum [PDF]

, 1994
A spectral timing model is developed to explain how the cerebellum learns adaptively timed responses during the rabbit's conditioned nictitating membrane response (NMR).
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intelligent Network Management and Functional Cerebellum Synthesis [PDF]

, 1989
Transdisciplinary modeling of the cerebellum across histology, physiology, and network engineering provides preliminary results at three organization levels: input/output links to central nervous system networks; links between the six neuron populations ...
Loebner, Egon E.
core   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source