Results 71 to 80 of about 3,979 (194)
Anticancer activity of the iron facilitator LS081 [PDF]
, 2011 Background Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer cell growth.
Zhen Li +3 more
core +2 more sources
Case Reports in Neurology, 2020 Subacute myelo-optico-neuropathy (SMON) is caused by the ingestion of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline), which is an intestinal antibacterial drug.
Tomoo Mano, Satoshi Kuru
doaj +1 more source
Chemistry – A European Journal, Volume 31, Issue 23, April 22, 2025.8‐Aminoquinoline half‐sandwich metal chlorido complexes were found to undergo conversion into dimetallic analogues under basic conditions and/or by the addition of AgNO3 to abstract the chlorido ligand. In in vitro anticancer activity studies, the dimetallic complexes were found to be in general more potent than the mononuclear analogues which can be ...
Tasha R. Steel +8 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.ATG16L1‐deficient macrophages exhibited impaired LC3B lipidation and accumulation of ROS, resulting in the activation of the NLRP3 inflammasome. Overactivated ATG16L1‐deficient macrophages aggravated the damage of alveolar epithelial cells, and increased the release of dsDNA.
Yan Bai +9 more
wiley +1 more source
Instrumental considerations and applications of elemental bio‐imaging [PDF]
, 2012 University of Technology, Sydney. Faculty of Science.Elemental Bio-Imaging (EBI) is an established application of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) that determines spatial distributions of in situ trace element ...
Lear, J
core
Memorias do Instituto Oswaldo Cruz, 2019 BACKGROUND Owing to increased spending on pharmaceuticals since 2010, discussions about rising costs for the development of new medical technologies have been focused on the pharmaceutical industry. Computational techniques have been developed to reduce
Renata Rachide Nunes +6 more
doaj +1 more source
Elemental bio-imaging : in situ analysis of trace elements in tissue by laser ablation-inductively coupled plasma-mass spectrometry [PDF]
, 2009 University of Technology, Sydney. Faculty of Science.Elemental bio-imaging is a new application of laser ablation - inductively coupled plasma - mass spectrometry (LA-ICP-MS) that determines in situ trace element concentrations in thin sections of ...
Hare, D
core
, 2009 El present article tracta de manera informal un tema cada vegada més candent a l’actualitat: l’experimentació amb animals en la investigació biomèdica.
Perelló Campaner, Catalina
core +2 more sources
A Novel Targeted and High‐Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease
Advanced Science, 2020 Alzheimer's disease (AD) remains the most prevalent neurodegenerative disease, and no effective treatment is available yet. Metal‐ion‐triggered aggregates of amyloid‐beta (Aβ) peptide and acetylcholine imbalance are reported to be possible factors in AD ...
Han Yang +10 more
doaj +1 more source
Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications
Frontiers in Neuroscience, 2018 As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids ...
Jun-Lin Liu +5 more
doaj +1 more source