Results 251 to 260 of about 169,769 (295)

Towards Practical Conservation Cloning: Understanding the Dichotomy Between the Histories of Commercial and Conservation Cloning. [PDF]

Animals (Basel)
Novak BJ, Brand S, Phelan R, Plichta S, Ryder OA, Wiese RJ.   +5 more
europepmc   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Next generation genetic screens in kinetoplastids. [PDF]

Nucleic Acids Res
Budzak J, Siegel TN.
europepmc   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Designing of multi-valent epitope vaccine displaying interactions with diverse HLA alleles against Candida auris using immuno-informatics. [PDF]

J Genet Eng Biotechnol
Ahlawat V, Sura K, Dangi M, Chhillar AK.
europepmc   +1 more source

Molecular Mechanisms of Somatic Cell Cloning and Other Assisted Reproductive Technologies in Mammals: Which Determinants Have Been Unraveled Thus Far?-Current Status, Further Progress and Future Challenges. [PDF]

Int J Mol Sci
Samiec M.
europepmc   +1 more source

Screening conditions and constructs for attempted genetic transformation of C. elegans by Agrobacterium. [PDF]

PLoS One
Warren EC, Brown AEX, Sarkisyan KS.
europepmc   +1 more source

<i>Haloferax volcanii</i>: a versatile model for studying archaeal biology. [PDF]

J Bacteriol
Pohlschroder M, Schulze S, Pfeiffer F, Hong Y.   +3 more
europepmc   +1 more source

Pulcherriminic acid biosynthesis and Transport: Insights from a heterologous system in Saccharomyces cerevisiae

Maciá Valero A, van Wageningen JJ, Foster AJ, Oliveira AR, Mayer C, Billerbeck S.   +5 more
europepmc   +1 more source