Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models [PDF]
Molecular NeurodegenerationBackground Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson’s disease (PD), yet the mechanistic link between them remains poorly understood.
Di Hu, Xiaoyan Sun, Xin Qi
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Mitochondrial Protease ClpP: Cancer Marker and Drug Target [PDF]
PharmaceuticalsBackground: The human mitochondrial ClpP is a serine protease located in the mitochondrial matrix responsible for degrading short lived regulatory proteins as well as misfolded or damaged proteins, thereby maintaining cellular homeostasis.
Domenico Armenise +8 more
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Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP [PDF]
Communications BiologyBacterial AAA+ proteases are composed of a AAA+ partner (e.g., ClpC) and an associated peptidase (e.g., ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence.
Stavros Azinas +6 more
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The ClpP protease homologue is required for the transmission traits and cell division of the pathogen
BMC Microbiology, 2010 Background Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the ...
Zhang Qin-fen +6 more
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Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy [PDF]
Oncology ReviewsMitochondrial “powerhouses” play a central function in cellular metabolism and energy generation. Their dysregulation is directly correlated with a myriad of diseases, among them cancer. The serine protease ClpP, accompanied by its cochaperone ClpX, is a
Mowei Kong +3 more
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Specific MRI abnormalities reveal severe Perrault syndrome due to CLPP defects [PDF]
Frontiers in Neurology, 2016 In establishing a genetic diagnosis in heterogeneous neurological disease, clinical characterization and whole exome sequencing (WES) go hand-in-hand. Clinical data are essential, not only to guide WES variant selection and define the clinical severity ...
Tom EJ Theunissen +16 more
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Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections [PDF]
Molecular MedicineThe rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li +9 more
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Effects of ClpP protease on biofilm formation of Enterococcus faecalis [PDF]
Journal of Applied Oral Science, 2021 Enterococcus faecalis (E. faecalis), one of the main pathogens responsible for refractory periapical periodontitis and nosocomial infections, exhibits markedly higher pathogenicity in biofilms. Objectives Studies have shown that caseinolytic protease P
Ying FENG +4 more
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ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway [PDF]
PeerJ, 2020 Background Caseinolytic protease P (ClpP), which is located on the inner mitochondrial membrane, degrades mitochondrial proteins damaged by oxidative stress. The role of ClpP varies among tumor types.
Juan Luo +4 more
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Modeling and Simulation of Dissemination of Cultivated Land Protection Policies in China
Land, 2021 Cultivated land protection is the top priority of the national economy in China and the livelihood of people. Cultivated land protection policies (CLPP) play an important role in the protection of cultivated land. However, the process of dissemination of
Xinhai Lu, Yanwei Zhang, Handong Tang
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