Results 91 to 100 of about 18,135 (204)
ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
eLife, 2020 AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim +4 more
doaj +1 more source
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria [PDF]
, 2016 Mitochondrial dysfunction is implicated in numerous neurodegenerative disorders and in Parkinson’s disease (PD) in particular. PINK1 and Parkin gene mutations are causes of autosomal recessive PD, and these respective proteins function cooperatively to ...
Pryde, KR, Schapira, AH, Taanman, JW
core +1 more source
PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 385-400, March 2026.Holoendoparasites are extremely rare plants that live entirely hidden inside their hosts, with only flowers and fruits visible. We studied Apodanthes caseariae, found in central and South America, parasitizing Casearia sylvestris. Little is known about its life cycle.
Jessica A. Ramírez‐Ramírez +4 more
wiley +1 more source
Pharmacodynamics of ClpP-Activating Antibiotic Combinations against Gram-Positive Pathogens [PDF]
Antimicrobial Agents and Chemotherapy, 2019 It is often difficult to cure endocarditis, osteomyelitis, and device-associated infections caused by Gram-positive pathogens, despite therapy with clinically appropriate antibiotics. This may be due to antibiotic tolerance or resistance development. Acyldepsipeptides (ADEPs) are a class of bactericidal compounds active against a variety of clinically ...
Nader, Mroue +6 more
openaire +2 more sources
Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]
, 2018 Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión +4 more
core +1 more source
Equine Veterinary Journal, Volume 58, Issue 2, Page 601-618, March 2026.Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule +10 more
wiley +1 more source
The Influence of the Toxin/Antitoxin mazEF on Growth and Survival of Listeria monocytogenes under Stress [PDF]
, 2017 A major factor in the resilience of Listeria monocytogenes is the alternative sigma factor B (σB). Type II Toxin/Antitoxin (TA) systems are also known to have a role in the bacterial stress response upon activation via the ClpP or Lon proteases. Directly
Curtis, Thomas +3 more
core +2 more sources
Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
Advanced Functional Materials, Volume 36, Issue 15, 19 February 2026.To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
wiley +1 more source
Frontiers in Microbiology, 2019 Legionella pneumophila, an environmental bacterium that parasitizes protozoa, is the causative pathogen of Legionnaires' disease. L. pneumophila adopts a distinct biphasic life cycle that allows it to adapt to environmental conditions for survival ...
Zhen-huang Ge +10 more
doaj +1 more source
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site. [PDF]
, 2019 Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition.
Asfaha, Jonathan B +6 more
core +1 more source