Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain [PDF]
Nature Communications, 2013 Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the ...
Fischer, Fabian +3 more
core +6 more sources
Open and compressed conformations of Francisella tularensis ClpP [PDF]
Proteins: Structure, Function, and Bioinformatics, 2017 Caseinolytic proteases are large oligomeric assemblies responsible for maintaining protein homeostasis in bacteria and in so doing influence a wide range of biological processes.
Alexopoulos +28 more
core +6 more sources
Bacterial ClpP Protease Is a Potential Target for Methyl Gallate [PDF]
Frontiers in Microbiology, 2021 Methyl gallate (MG) is an effective microbicide with great potential application in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown.
Dehong Zheng +4 more
doaj +3 more sources
Generation of Lasso Peptide-Based ClpP Binders [PDF]
International Journal of Molecular Sciences, 2021 The Clp protease system fulfills a plethora of important functions in bacteria. It consists of a tetradecameric ClpP barrel holding the proteolytic centers and two hexameric Clp-ATPase rings, which recognize, unfold, and then feed substrate proteins into the ClpP barrel for proteolytic degradation.
Imran T. Malik +2 more
openaire +2 more sources
The depletion of serine beta-lactamase-like protein (LACTB) ameliorates metabolic dysfunction-associated steatotic liver disease by reducing ubiquitin-mediated degradation of carnitine palmitoyltransferase 2. [PDF]
Diabetes Obes MetabAbstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Shi W +10 more
europepmc +2 more sources
Virulence, 2022 The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased dramatically due to the misuse of antibiotics, and thus the development of new anti-infective drugs with new targets is urgently needed to combat resistance ...
Shisong Jing +12 more
doaj +1 more source
SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes [PDF]
, 2017 SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood.
Gary C. Port +4 more
core +9 more sources
Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function
Antioxidants, 2020 Mitochondrial unfolded protein response (UPRmt) is a highly conserved mechanism, which is activated upon cellular or metabolic stress and aims to help cells maintain homeostasis.
Ecem Esencan +3 more
doaj +1 more source
The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. [PDF]
PLoS ONE, 2013 In the respiratory tract and lung tissue, a balanced physiological response is essential for Actinobacillus pleuropneumoniae to survive various types of challenges.
Fang Xie +5 more
doaj +1 more source
Dysregulating ClpP: From Antibiotics to Anticancer? [PDF]
Cell Chemical Biology, 2018 In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
David A, Dougan +2 more
openaire +2 more sources