Results 21 to 30 of about 18,135 (204)

The cryo-EM structure of the chloroplast ClpP complex [PDF]

Nature Plants, 2021
Protein homoeostasis in plastids is strategically regulated by the protein quality control system involving multiple chaperones and proteases, among them the Clp protease. Here, we determined the structure of the chloroplast ClpP complex from Chlamydomonas reinhardtii by cryo-electron microscopy. ClpP contains two heptameric catalytic rings without any
Wang, Ning, Wang, Yifan, Zhao, Qian, Zhang, Xiang, Peng, Chao, Zhang, Wenjuan, Liu, Yanan, Vallon, Olivier, Schroda, Michael, Cong, Yao, Liu, Cuimin   +10 more
openaire   +3 more sources

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities [PDF]

, 2013
PMCID: PMC3613350This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Bellier, A Milano, A Singh, A Wawrzynow, AM Sherrid, AM Socha, Amanda C. Brown, Anil Kumar Tyagi, CA Pashley, D Weichart, DG Muttucumaru, DL Schuessler, Dorothée L. Schuessler, E Kruger, GR Stewart, H Brotz-Oesterhelt, H Ingvarsson, HI Boshoff, I Levchenko, J Braman, J Kirstein, J Ollinger, J Porankiewicz, JB Andersen, JH Kim, JM Flynn, LE Thomsen, LG Wayne, M Estorninho, M Gomez, MC Blokpoel, ND Rawlings, O Dussurget, P Carroll, P Carroll, P Gueneau de Novoa, R Manganelli, RM Raju, S Ahlawat, S Barik, S Engels, S Engels, S Mehra, S Russo, ST Cole, T Akopian, T Msadek, T Parish, Tanya Parish, Yoann Personne   +49 more
core   +6 more sources

Soil Microbial Activity and Diversity in Response to Soil Chemical Factors in Agricultural Soils

Journal of Tropical Soils, 2019
The role of microbial communities in maintaining soil health is mostly influenced by chemical condition of soil. Microbial communities vary in response to soil chemical factors.
Lily Ishak, Philip Hugh Brown
doaj   +1 more source

Evaluation the effect of cultivated land protection policies based on the cloud model: A case study of Xingning, China

Ecological Indicators, 2021
The evaluation of the effects of cultivated land protection policies (CLPP) is an important issue in China’s food security and land policy regulation. This article first analyzes the historical evolution of CLPP in China and divides it into five stages ...
Xinhai Lu, Yanwei Zhang, Yucheng Zou
doaj   +1 more source

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]

, 2010
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Butler, R.E., Estorninho, M., Harders-Westerveen, S.F., Kierzek, A., Neyrolles, O., Smith, H.E., Stewart, G.R., Thole, J.E.R.   +7 more
core   +3 more sources

Ureadepsipeptides as ClpP Activators

ACS Infectious Diseases, 2019
Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill nongrowing bacteria represents a new opportunity to combat deep-seated biofilm infections.
Elizabeth C. Griffith, Ying Zhao, Aman P. Singh, Brian P. Conlon, Rajendra Tangallapally, William R. Shadrick, Jiuyu Liu, Miranda J. Wallace, Lei Yang, John M. Elmore, Yong Li, Zhong Zheng, Darcie J. Miller, Martin N. Cheramie, Robin B. Lee, Michael D. LaFleur, Kim Lewis, Richard E. Lee   +17 more
openaire   +3 more sources

Cellular functions of the ClpP protease impacting bacterial virulence

Frontiers in Molecular Biosciences, 2022
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent degradation of target substrates.
Mazen E. Aljghami, Marim M. Barghash, Emily Majaesic, Vaibhav Bhandari, Walid A. Houry, Walid A. Houry   +5 more
openaire   +3 more sources

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Nature Communications, 2023
Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma.
Lin-Lin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji, Cai-Guang Yang   +12 more
doaj   +1 more source

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
doaj   +1 more source

Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]

, 2018
Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson, K Devaraj, Neal, M Cole, Christian, Shi, Xinying, Wu, Ti   +4 more
core   +2 more sources