Results 31 to 40 of about 18,135 (204)

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +1 more source

Environmental stress responses in Lactococcus lactis [PDF]

, 1999
Bacteria can encounter a variety of physical conditions during their life. Bacterial cells are able to survive these (often adverse) conditions by the induction of specific or general protection mechanisms. The lactic acid bacterium Lactococcus lactis is
Kok, Jan,, Sanders, Jan Willem,, Venema, Gerard,   +2 more
core   +3 more sources

Turned on for degradation: ATPase-independent degradation by ClpP [PDF]

Journal of Structural Biology, 2009
Clp is a barrel-shaped hetero-oligomeric ATP-dependent protease comprising a hexameric ATPase (ClpX or ClpA) that unfolds protein substrates and translocates them into the central chamber of the tetradecameric proteolytic component (ClpP) where they are degraded processively to short peptides. Chamber access is controlled by the N-terminal 20 residues (
Maria C, Bewley, Vito, Graziano, Kathleen, Griffin, John M, Flanagan   +3 more
openaire   +2 more sources

A sensitive soil biological indicator to changes in land-use in regions with Mediterranean climate

Scientific Reports, 2022
The demand for reliable indicators to quantify soil health has increased recently. We propose and test the use of soil microbial functional diversity as an indicator of multifunctional performance in agriculturally important areas. Agricultural fields in
Yosef Steinberger, Alfred Stein, Michael Dorman, Tal Svoray, Tirza Doniger, Oshri Rinot, Eshel Gil   +6 more
doaj   +1 more source

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding [PDF]

, 2010
ClpP is a self-compartmentalized protease, which has very limited degradation activity unless it associates with ClpX to form ClpXP or with ClpA to form ClpAP.
Barkow, Bewley, Bewley, Bogyo, Breusing, Brotz-Oesterhelt, Burton, Burton, Farrell, Flynn, Goldberg, Gottesman, Gottesman, Gottesman, Gribun, Grimaud, Groll, Hersch, Ingvarsson, Jenal, Jennings, Joshi, Kang, Kenniston, Kessel, Kim, Kim, Kim, Kirstein, Kwon, Levchenko, Liu, Martin, Martin, Martin, Mary E. Lee, Maurizi, Maurizi, Ortega, Powers, Rabl, Reinstein, Robert T. Sauer, Sauer, Siddiqui, Singh, Singh, Smith, Smith, Song, Sousa, Sousa, Striebel, Szyk, Tania A. Baker, Thompson, Thompson, Wang, Whitby, Yoo, Yu   +60 more
core   +1 more source

Complementation studies with human ClpP in Bacillus subtilis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020
ATP-dependent intracellular proteolysis is essential for all living organisms. ClpP, the proteolytic subunit of the ATP-dependent Clp proteases, shares 56% protein identity between B. subtilis and man. The aim of this study was to verify, whether human ClpP (HClpP) is able to substitute the bacterial pendant, BClpP, irrespectively of the huge ...
Denise, Dittmar, Alexander, Reder, Rabea, Schlüter, Katharina, Riedel, Michael, Hecker, Ulf, Gerth   +5 more
openaire   +2 more sources

CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality–Mediated mitochondrial dysfunction

Frontiers in Genetics, 2023
Premature ovarian insufficiency (POI) is characterized by early loss of ovarian function before the age of 40 years. It is confirmed to have a strong and indispensable genetic component.
Xiong Yuan, Xiong Yuan, Wenjie Ma, Wenjie Ma, Shuping Chen, Shuping Chen, Huiyuan Wang, Huiyuan Wang, Chenyi Zhong, Chenyi Zhong, Li Gao, Li Gao, Yugui Cui, Yugui Cui, Danhua Pu, Danhua Pu, Rongrong Tan, Rongrong Tan, Jie Wu, Jie Wu   +19 more
doaj   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia

Microbiology Spectrum, 2022
The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there is an urgent need to identify novel anti-infective agents to attack new
Shisong Jing, Xiangri Kong, Li Wang, Heming Wang, Jiaxuan Feng, Lin Wei, Ying Meng, Chang Liu, Xiren Chang, Yishen Qu, Jiyu Guan, Haimiao Yang, Chi Zhang, Yicheng Zhao, Wu Song   +14 more
doaj   +1 more source

Soil biological quality of grassland fertilized with adjusted cattle manure slurries in comparison with organic and inorganic fertilizers [PDF]

, 2009
We studied the effect of five fertilizers (including two adjusted manure slurries) and an untreated control on soil biota and explored the effect on the ecosystem services they provided.
Bloem, J., Boer, Herman, de, Brussaard, L., Eekeren, N.J.M., van, Goede, R.G.M., de, Rutgers, M., Schouten, T.   +6 more
core   +2 more sources