Results 131 to 140 of about 152,432 (174)

Mechanisms of allosteric regulation in human mitochondrial ClpP protease

Human ClpXP is a mitochondrial proteolytic complex, composed of the ClpX unfoldase and the ClpP protease, that mediates protein quality control. ClpP is an established cancer target overexpressed in various malignancies, including in acute myeloid leukemia (AML) where altered ClpP activity leads to aberrant degradation of respiratory chain subunits and
openaire   +1 more source

The role of mitochondrial proteases in inflammation and immunity. [PDF]

Front Immunol
Ferreira ARO, Day EA.
europepmc   +1 more source

Components of the Clp complex are required for sporangium formation and dehiscence in <i>Actinoplanes missouriensis</i>. [PDF]

J Bacteriol
Suzuki R, Maruko M, Suzuki R, Tezuka T, Ohnishi Y.   +4 more
europepmc   +1 more source

Dual role of HIF-1α in gliomas: enhancing COX7A2 degradation and SCAF1 expression for ATP production and tumor progression. [PDF]

Am J Cancer Res
Lai M, Feng W, Ouyang J, Kuang J, Deng S.   +4 more
europepmc   +1 more source

ClpP deficiency attenuates contrast-induced HK-2 cell injury through changes associated with mitochondrial dynamics and apoptosis. [PDF]

PLoS One
Wang J, Wang L, Xie L, Tang C.
europepmc   +1 more source

A mitochondrial insertion directs substrate selection and engagement by the protein unfoldase ClpX. [PDF]

J Biol Chem
DeCosta A, Barrick R, Kardon JR.
europepmc   +1 more source

Small molecule activators of the mitochondrial protease ClpP induce senescence in triple-negative breast cancer cells and sensitize cells to the Bcl-2 inhibitor venetoclax. [PDF]

Cell Death Dis
Daglish SCD, Canterbury OG, Graves PR, Carter SA, Beese SM, Mouery BL, Hynek MA, Moorman EC, Mistreanu AJ, Bhatt AP, Tellez N, Butler MT, Aponte-Collazo LJ, Fennell EMJ, Herring LE, Lyons S, Mills CA, Ashamalla H, Iwanowicz EJ, Morris Iv JP, Bear JE, Greer YE, Lipkowitz S, Graves LM.   +23 more
europepmc   +1 more source

Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity. [PDF]

Cell Biosci
Shi K, Liu H, Xu H, Shang W, Wang L, Tong C.   +5 more
europepmc   +1 more source

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif. [PDF]

Nat Commun
Kan J, Spotton K, Morales-Amador A, Hernandez Y, Burian J, Panfil C, Ternei MA, Boer RE, Bhattacharjee A, Brady SF.   +9 more
europepmc   +1 more source

Fred Goldberg machines in the pathogenesis of Mycobacterium tuberculosis. [PDF]

J Biol Chem
Darwin KH.
europepmc   +1 more source