Results 141 to 150 of about 152,432 (174)

The role of dordaviprone in the multidisciplinary management of diffuse midline glioma. [PDF]

Surg Neurol Int
Al Lawati AM, Al Suleimani MK, Al Rasbi IA, Al Hinai MA, Al Marbouai SB, Al Barhi HB, Al Lawati HM, Al Sideiri GS.   +7 more
europepmc   +1 more source

ClpP Ensures Mitochondrial Integrity and Spermatocyte Meiotic Progression in Mice. [PDF]

Andrology
Feng HW, Gao YL, Jiang BJ, Zubair M, Liu DT, Xu ZS, Wang ZZ, Wang HL, Wang XM, Sun JX, Zeng GH, Huo LJ.   +11 more
europepmc   +1 more source

Structural basis of the AlgU-MucA^cyto interaction and SspB-mediated degradation in <i>Pseudomonas aeruginosa</i> stress response. [PDF]

mBio
Li T, Wang Y, Zhao N, Ge C, Wu C, Li K, Li L, Wang Z, Chen Y, Chen Z, Li W, Liu Y, Wang Z, Sha Y, Yao H, Zhu Y, Bao R.   +16 more
europepmc   +1 more source

Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine three-hit model of heart failure with preserved ejection fraction. [PDF]

Am J Physiol Heart Circ Physiol
Li X, Fu Y, do Carmo JM, da Silva AA, Mouton AJ, Omoto ACM, Wang L, Hall JE, Wang Z.   +8 more
europepmc   +1 more source

CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells. [PDF]

Nat Commun
Huang C, Zhang Y, Gao H, Song Y, Hu S, Sun C, Duan S, Ma D, Jiang X, Liu G.   +9 more
europepmc   +1 more source

Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models. [PDF]

Med Chem Res
Hao X, Purohit G, Jayasinghe YP, Ronning DR, Khalimonchuk O, Trippier PC.   +5 more
europepmc   +1 more source

Molecular mechanisms of mitochondrial AAA+ proteases. [PDF]

J Biol Chem
Currie SQW, Goncalves MM, Schimmer AD, Vahidi S.   +3 more
europepmc   +1 more source

A Conformational Switch Underlies ClpP Protease Function [PDF]

Angewandte Chemie - International Edition, 2011
A “breathing” protein: The first structure of the virulence regulator and heat shock protein ClpP from Staphylococcus aureus reveals a previously unobserved compressed state of the ClpP barrel. A conformational switch in the active center “handle region” results in closure of the active sites and opening of equatorial pores.
Patrick Cramer, Stephan A. Sieber, Thomas Böttcher   +2 more
exaly   +7 more sources

Substrates and Interactors of the ClpP Protease in the Mitochondria

Current Opinion in Chemical Biology, 2022
The ClpP protease is found across eukaryotic and prokaryotic organisms. It is well-characterized in bacteria where its function is important in maintaining protein homeostasis. Along with its ATPase partners, it has been shown to play critical roles in the regulation of enzymes involved in important cellular pathways.
Walid A Houry, Vaibhav Bhandari, Mark F Mabanglo   +2 more
exaly   +3 more sources