Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review). [PDF]
Oncol RepWu W, Chen W, Ma W, Wang Y.
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A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae. [PDF]
PLoS GenetMaziero M +8 more
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Selective Activation of Human Caseinolytic Protease P (ClpP)
Angewandte Chemie International Edition, 2018AbstractCaseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria‐specific unfolded protein response (UPRmt). However, its detailed function and dedicated regulation remain largely unexplored.
Matthias Stahl +9 more
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Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases
Critical Reviews in Biochemistry and Molecular Biology, 2014ClpP is a highly conserved serine protease present in most bacterial species and in the mitochondria of mammalian cells. It forms a cylindrical tetradecameric complex arranged into two stacked heptamers. The two heptameric rings of ClpP enclose a roughly spherical proteolytic chamber of about 51 Å in diameter with 14 Ser-His-Asp proteolytic active ...
Kaiyin, Liu +2 more
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The Mechanism of Caseinolytic Protease (ClpP) Inhibition
Angewandte Chemie International Edition, 2013Malte Gersch +9 more
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A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents
Bioorganic & Medicinal Chemistry, 2017The prokaryotic ATP-dependent ClpP protease, localized in the relict plastid of malaria parasite, represents a potential drug target. In the present study, we utilized in silico structure-based screening and medicinal chemistry approaches to identify a novel pyrimidine series of compounds inhibiting P.
Sourabh, Mundra +11 more
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Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice
Journal of Hepatology, 2022Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced by insufficiency of the mitochondrial matrix caseinolytic protease P (ClpP), can potentially cause mitochondrial dysfunction.
Sung-E Choi +13 more
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Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities
ACS Chemical Biology, 2015ClpP is a self-compartmentalizing protease with crucial roles in bacterial and mitochondrial protein quality control. Although the ClpP homocomplex is composed of 14 equivalent active sites, it degrades a multitude of substrates to small peptides, demonstrating its capability to carry out diverse cleavage reactions.
Malte, Gersch +6 more
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Characterization of mouse Clpp protease cDNA, gene, and protein
Mammalian Genome, 2000Mutations that cause accumulation or rapid degradation owing to protein misfolding are a frequent cause of inherited disease in humans. In Escherichia coli, Clpp protease is one of the components of the protein quality control system that handles misfolded proteins.
Andresen, B S +7 more
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ClpP: A structurally dynamic protease regulated by AAA+ proteins
Journal of Structural Biology, 2012Proteolysis is an important process for many aspects of bacterial physiology. Clp proteases carry out a large proportion of protein degradation in bacteria. These enzymes assemble in complexes that combine the protease ClpP and the unfoldase, ClpA or ClpX.
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