Results 181 to 190 of about 9,876 (190)

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Cancer Cell, 2019
Jo Ishizawa, R Eric Davis, Ondrej Halgas
exaly  

UNDERSTANDING THE ACTIVATION OF BACTERIAL PROTEASE CLPP BY ACYLDEPSIPEPTIDE ANTIBIOTIC

2014
Acyldepsipeptide (ADEP1) is an antibiotic that binds to Escherichia coli ClpP, mimicking the interaction that the protease typically establishes with ClpA/ClpX ATPases in bacterial cells. Binding of ADEP1 causes the N-terminal end of the ClpP to adopt a structured β-hairpin and triggers opening of the axial gate in the tetradecameric ClpP.
openaire   +1 more source

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

Cell Chemical Biology, 2018
Keith S Wong, Kamran Rizzolo, Sadhna Phanse   +2 more
exaly  

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

EMBO Molecular Medicine, 2009
Janine Kirstein, Heike Brötz-Oesterhelt, Axel Mogk   +2 more
exaly  

The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis

Cell, 1997
Jimin Wang
exaly  

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

Journal of Biological Chemistry, 2012
Malte Gersch, Michael Groll, Stephan A Sieber   +2 more
exaly  

Activated ClpP kills persisters and eradicates a chronic biofilm infection

Nature, 2013
exaly  

Analysis of two ClpP proteases in Myxococcus xanthus

2015
openaire   +1 more source

Structural characterization of caseinolytic protease (ClpP) from Klebsiella pneumonia.

openaire   +1 more source

Developing a library of HaloPROTACs targeting the ClpP protease

openaire   +1 more source