Results 121 to 130 of about 9,876 (190)

Structure characterization and mechanism of angiotensin I-converting enzyme (ACE) inhibitory peptides modified by plastein reaction derived from tiger nut (Cyperus esculentus)

Frontiers in Sustainable Food Systems
The development of peptides derived from plants, which have potential anti-angiotensin converting enzyme (ACE) activity and other bioactivities, are of scientific interest.
Junhua Shi, Zhuo Yang, Ming Xu, Guogang Zhao, Yawen Gao, Hongyan Zheng, Ji Feng   +6 more
doaj   +1 more source

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

Acta Biochimica et Biophysica Sinica
Currently, platinum agents remain the mainstay of chemotherapy for ovarian cancer (OC). However, cisplatin (DDP) resistance is a major reason for chemotherapy failure.
Kou Xinxin, Yang Xiaoxia, Zhao Zheng, Li Lei   +3 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source

Expression of type II toxin-antitoxin systems and ClpP protease of methicillin-resistant Staphylococcus aureus under thermal and oxidative stress conditions. [PDF]

Iran J Microbiol, 2021
Karimaei S, Kalani BS, Shahrokhi N, Mashhadi R, Pourmand MR.   +4 more
europepmc   +1 more source

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention [PDF]

, 2017
Mitochondrial diseases often exhibit tissue-specific pathologies, but this phenomenon is poorly understood. Here we present regulation of mitochondrial translation by the Mitochondrial Translation Optimization Factor 1, MTO1, as a novel player in this ...
Becker, Lore, Chrzanowska-Lightowlers, Zofia, Datta, Alexandre N., De Angelis, Martin Hrabe, Dumitru, Iulia, Floss, Thomas, Haack, Tobias, Hofer, Annette, Klopstock, Thomas, Kremer, Laura, Prokisch, Holger, Sperl, Wolfgang, Stepek, Joanna, Tischner, Christin, Wenz, Tina, Wulff, Veronika, Wurst, Wolfgang   +16 more
core  

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents

Cell Reports Medicine
Summary: Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP) is a promising target for
Tao Zhang, Pengyu Wang, Hailing Zhou, Bingyan Wei, Yanling Zhao, Jiahui Li, Min Zhang, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang   +10 more
doaj   +1 more source

Requirements for the light-stimulated degradation of stromal proteins in isolated pea (Pisum sativum L.) chloroplasts [PDF]

, 2017
Chloroplasts from 17-d-old pea leaves (Pisum sativum L.) were isolated to elucidate the requirements for the light-induced degradation of stromal proteins.
Feller, Urs, Stieger, Pia Angela
core  

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj   +1 more source

Ferritin Degradation by Pneumococcal HtrA, RadA and ClpP Serine Proteases : A Probable Way For Releasing and Acquisition Of Iron

Infection and Drug Resistance, 2020
Mozhgan Kheirandish,1 Behrooz Motlagh,2 Davoud Afshar1 1Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; 2Department of Clinical Biochemistry, School of Medicine, Zanjan University of ...
Kheirandish M, Motlagh B, Afshar D
doaj  

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. [PDF]

Genetics, 2020
Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M.   +13 more
europepmc   +1 more source