Results 111 to 120 of about 9,876 (190)

Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation

Scientific Reports, 2017
ClpXP is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. ClpXP is composed of a proteolytic subunit, ClpP, and a chaperone-like subunit, ClpX. Although it has been proposed that ClpXP is required for the
Yuichi Matsushima, Yuta Hirofuji, Masamune Aihara, Song Yue, Takeshi Uchiumi, Laurie S. Kaguni, Dongchon Kang   +6 more
doaj   +1 more source

The Protein Chaperone ClpX Targets Native and Non-native Aggregated Substrates for Remodeling, Disassembly, and Degradation with ClpP

Frontiers in Molecular Biosciences, 2017
ClpX is a member of the Clp/Hsp100 family of ATP-dependent chaperones and partners with ClpP, a compartmentalized protease, to degrade protein substrates bearing specific recognition signals.
Christopher J. LaBreck, Shannon May, Marissa G. Viola, Joseph Conti, Jodi L. Camberg   +4 more
doaj   +1 more source

Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. [PDF]

, 2020
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients
Ahmed, Mohamed Sohail, Ambati, Aditya, Inayathullah, Mohammed, Mallajosyula, Venkata Vamsee Aditya, Pothineni, Venkata Raveendra, Potula, Hari-Hara SK, Rajadas, Jayakumar, Sridharan, Brindha   +7 more
core  

The rgg0182 gene encodes a transcriptional regulator required for the full Streptococcus thermophilus LMG18311 thermal adaptation [PDF]

, 2011
Conclusions: These data showed the importance of the Rgg(0182) transcriptional regulator on the survival of S.
Bernard Decaris, Betty Fleuchot, Emmanuelle Bruneau, Nathalie Leblond-Bourget, Romain Henry, Rozenn Gardan, Stéphane Bertin   +6 more
core   +6 more sources

Protein degradation by a component of the chaperonin‐linked protease ClpP

Genes to Cells
AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins.
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi   +3 more
openaire   +2 more sources

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment

Cell Reports Medicine
Summary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Song Liu, Linjie Li, Zhengyi Dai, Lidan Zhang, Ziyi Shu, Lili Li, Hu Zhang, Tao Yang, Youfu Luo   +13 more
doaj   +1 more source

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells [PDF]

, 2019
Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis.
Daverey, Amita, Hayward, Stephen, Khalimonchuk, Oleh, Kidambi, Srivatsan, Levytskyy, Roman M., Narasimhan, Madhusudhanan, Ponte Viana, Martonio, Stanke, Kimberly M., Swenson, Samantha   +8 more
core   +1 more source

Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis. [PDF]

EMBO J, 2022
Kim L, Lee BG, Kim M, Kim MK, Kwon DH, Kim H, Brötz-Oesterhelt H, Roh SH, Song HK.   +8 more
europepmc   +1 more source

Molecular Basis of ClpP Protease Activation by Small Molecules

The FASEB Journal, 2019
Bacterial ClpP is a highly conserved, self‐compartmentalizing, cylindrical serine protease required for maintaining cellular proteostasis. Acyldepsipeptides (ADEPs) and activators of self‐compartmentalized proteases (ACPs) are small molecules that cause the dysregulation and activation of ClpP, which leads to bacterial cell death ...
openaire   +1 more source

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source