Results 91 to 100 of about 9,876 (190)

The ClpP N-Terminus Coordinates Substrate Access with Protease Active Site Reactivity [PDF]

Biochemistry, 2008
Energy-dependent protein degradation machines, such as the Escherichia coli protease ClpAP, require regulated interactions between the ATPase component (ClpA) and the protease component (ClpP) for function. Recent studies indicate that the ClpP N-terminus is essential in these interactions, yet the dynamics of this region remain unclear.
Laura D, Jennings, Jen, Bohon, Mark R, Chance, Stuart, Licht   +3 more
openaire   +2 more sources

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

Neoplasia: An International Journal for Oncology Research, 2020
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agonist ...
Varun Vijay Prabhu, Sara Morrow, Abed Rahman Kawakibi, Lanlan Zhou, Marie Ralff, Jocelyn Ray, Aakash Jhaveri, Isacco Ferrarini, Young Lee, Cassandra Parker, Yiqun Zhang, Robyn Borsuk, Wen-I Chang, Joshua N. Honeyman, Fabio Tavora, Benedito Carneiro, Alexander Raufi, Kelsey Huntington, Lindsey Carlsen, Anna Louie, Howard Safran, Attila A. Seyhan, Rohinton S. Tarapore, Lee Schalop, Martin Stogniew, Joshua E. Allen, Wolfgang Oster, Wafik S. El-Deiry   +27 more
doaj   +1 more source

Plastid Genome Evolution Across the Roridulaceae–Sarraceniaceae Clade (Ericales) in Relation to Carnivorous Strategies

Ecology and Evolution, Volume 16, Issue 4, April 2026.
The Roridulaceae–Sarraceniaceae clade exhibits strikingly divergent carnivorous strategies, providing a framework to examine how trophic shifts influence plastid genome evolution. Comparative plastome analyses reveal recurrent ndh gene disruption across species, while Roridula gorgonias shows pronounced genomic restructuring, including elevated ...
Shengxin Chang, Peng Wang, Wei Han, Baiyin Yu, Chunxia Li   +4 more
wiley   +1 more source

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

Molecules
Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence.
Shi Wang, Yingying Jiang, Weijie Zhang, Yingzhu Wei, Xing Xiao, Zhiqing Wei, Xiaoxin Wen, Yuhang Dong, Jichang Jian, Na Wang, Huanying Pang   +10 more
doaj   +1 more source

Exploring the Diversity and Function of the SPFH‐Domain Containing Proteins in Pseudomonas aeruginosa

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
We characterised nine SPFH‐domain containing proteins in Pseudomonas aeruginosa PA14 and found remarkable sequence divergence and scattered evolutionary distribution. Functional analyses showed that single or multiple deletions had no detectable impact on growth, motility, biofilm formation, stress resistance or virulence under laboratory conditions ...
Víctor Manuel García‐Maldonado, Claudia Rodríguez‐Rangel, Dimitris Georgellis, Adrián F. Alvarez   +3 more
wiley   +1 more source

Regulation of Cyclic Lipopeptide Biosynthesis inPseudomonas fluorescensby the ClpP Protease [PDF]

Journal of Bacteriology, 2009
ABSTRACTCyclic lipopeptides produced byPseudomonasspecies exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic regulatory network.
de Bruijn, I., Raaijmakers, J.M.
openaire   +2 more sources

Identification of an Unusual Intein in Chloroplast ClpP Protease of Chlamydomonas eugametos [PDF]

Journal of Biological Chemistry, 1997
The proteasome-like ClpP protease is widely distributed and structurally conserved among bacteria and eukaryotic cell organelles. In Chlamydomonas eugametos, however, the chloroplast clpP gene predicted a much larger ClpP protein containing large insertion sequences (ISs).
S, Wang, X Q, Liu
openaire   +2 more sources

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation [PDF]

, 2009
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (leaves 67-71).Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in ...
Shin, Yongdae
core  

Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases [PDF]

, 2015
ATP-dependent molecular machines of the AAA+ superfamily unfold or remodel proteins in all cells. For example, AAA+ ClpX and ClpA hexamers collaborate with the self-compartmentalized ClpP peptidase to unfold and degrade specific proteins in bacteria and ...
Baker, Tania, Baytshtok, Vladimir, Sauer, Robert T.   +2 more
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, Volume 16, Issue 3, Page 503-519, March 2026.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source