Results 91 to 100 of about 152,432 (174)
, 2022 In Staphylococcus aureus, the SaeRS two-component system is essential for the bacterium’s hemolytic activity and virulence. The Newman strain of S. aureus contains a variant of SaeS sensor kinase, SaeS L18P.
Min Li (12799) +9 more
core +1 more source
Complete Chloroplast Genome of Cardamine microzyga and Phylogenetic Analysis
Ecology and Evolution, Volume 16, Issue 7, July 2026.This study reports the first complete chloroplast genome of Cardamine microzyga, a perennial herb from mountainous southwestern China. The genome is 154,661 bp in length with a typical quadripartite structure and contains 129 genes. Comparative genomic analyses identified several hypervariable regions (e.g., trnS‐GCU, rrn4.5S, ycf1) as promising DNA ...
Yongming Fan +7 more
wiley +1 more source
ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
Neoplasia: An International Journal for Oncology Research, 2020 ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agonist ...
Varun Vijay Prabhu +27 more
doaj +1 more source
Recognition, targeting, and hydrolysis of the lambda O replication protein by the ClpP/ClpX protease
, 1999 It has previously been established that sequences at the C termini of polypeptide substrates are critical for efficient hydrolysis by the ClpP/ClpX ATP-dependent protease.
Um, S. J. +8 more
core +1 more source
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active‐Site Inhibitor Cystargolide A [PDF]
The caseinolytic protease is a highly conserved serine protease, crucial to prokaryotic and eukaryotic protein homeostasis, and a promising antibacterial and anticancer drug target.
Kaysser, Leonard +15 more
core +1 more source
Initial Characterization of the Two ClpP protease isoforms from Chlamydia trachomatis [PDF]
, 2018 Chlamydia trachomatis is an obligate intracellular bacterial pathogen responsible for sexually transmitted infections and the ocular infection trachoma.
Chung, Krystal
core
Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities [PDF]
, 2013 PMCID: PMC3613350This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Brown Amanda C. +11 more
core +1 more source
Scientific Reports, 2017 ClpXP is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. ClpXP is composed of a proteolytic subunit, ClpP, and a chaperone-like subunit, ClpX. Although it has been proposed that ClpXP is required for the
Yuichi Matsushima +6 more
doaj +1 more source
ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus. [PDF]
Vet Res, 2023 Sun D +11 more
europepmc +1 more source
, 2022 Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem cancer and a leading cause of pediatric brain tumor-related death with the median survival of 10 months post-diagnosis.
Perrone M. G. +7 more
core