Results 91 to 100 of about 5,899 (155)

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents

Cell Reports Medicine
Summary: Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP) is a promising target for
Tao Zhang, Pengyu Wang, Hailing Zhou, Bingyan Wei, Yanling Zhao, Jiahui Li, Min Zhang, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang   +10 more
doaj   +1 more source

The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma

Blood
Abstract Orchestrating key homeostatic functions, mitochondria likely entail cancer vulnerabilities. Moreover, because of their bacterial ancestry, they can release potent immunogenic signals. In this study, we showed that the mitochondrial protease caseinolytic peptidase P (ClpP) is both a cell-intrinsic metabolic ...
Tommaso Perini, Paola Zordan, Rossella Del Pizzo, Massimo Resnati, Lisa Viviani, Davide Stefanoni, Laura Cassina, Ugo Orfanelli, Matteo Trudu, Laura Oliva, Daniel Lacidogna, Mehmet K. Samur, Maria Materozzi, Denise Drago, Annapaola Andolfo, Marco Patrone, Massimo Degano, Alessandra Boletta, Enrico Milan, Fabio Ciceri, Nikhil C. Munshi, Matteo Bellone, Simone Cenci   +22 more
openaire   +3 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj   +1 more source

Developing a library of HaloPROTACs targeting the ClpP protease

Proteolysis-targeting chimeras (PROTACs) have received recent attention as a new therapeutic agent that have the potential to have a great impact in drug discovery. This project focuses on developing a chemical approach to utilise caseinolytic protease proteolytic (CLpP), a mitochondrial protease, as a potential target for mitochondrial selective ...
openaire   +2 more sources

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. [PDF]

Genetics, 2020
Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M.   +13 more
europepmc   +1 more source

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors. [PDF]

Sci Adv, 2019
Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.   +11 more
europepmc   +1 more source

Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides. [PDF]

EMBO J
Jenne T, Engelhardt L, Baronaite I, Levy D, Riven I, Malolepszy M, Azinas S, Sych T, Sezgin E, Flemming D, Sinning I, Haran G, Carroni M, Mogk A.   +13 more
europepmc   +1 more source

ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores. [PDF]

Commun Biol, 2019
Mabanglo MF, Leung E, Vahidi S, Seraphim TV, Eger BT, Bryson S, Bhandari V, Zhou JL, Mao YQ, Rizzolo K, Barghash MM, Goodreid JD, Phanse S, Babu M, Barbosa LRS, Ramos CHI, Batey RA, Kay LE, Pai EF, Houry WA.   +19 more
europepmc   +1 more source

A novel membrane stress response that blocks chromosomal replication by targeting the DnaA initiator via the ClpP protease. [PDF]

J Bacteriol
Gbolahan A, Li T, Saxena R, Wolcott K, Sohail A, Ahmed I, Chattoraj DK, Crooke E, Saxena R.   +8 more
europepmc   +1 more source