Results 81 to 90 of about 9,876 (190)
Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines [PDF]
, 2017 AAA+ proteases and remodeling machines couple hydrolysis of ATP to mechanical unfolding and translocation of proteins following recognition of sequence tags called degrons.
Baker, Tania +4 more
core +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Biomedicines, 2021 Triple-negative breast cancer (TNBC) is a heterogeneous group of estrogen, progesterone, and HER2-negative breast cancers with poor clinical outcomes. The imipridone ONC201 is a G-protein-coupled dopamine receptor D2 modulator and an allosteric agonist ...
Bora Lim +8 more
doaj +1 more source
ClpXP protease targets long-lived DNA translocation states of a helicase-like motor to cause restriction alleviation [PDF]
, 2014 We investigated how Escherichia coli ClpXP targets the helicase-nuclease (HsdR) subunit of the bacterial Type I restriction–modification enzyme EcoKI during restriction alleviation (RA).
Diffin, Fiona M +2 more
core +2 more sources
Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis +6 more
wiley +1 more source
Role of Hsp100/Clp Protease Complexes in Controlling the Regulation of Motility in Bacillus subtilis [PDF]
, 2016 The Hsp100/Clp protease complexes of Bacillus subtilis ClpXP and ClpCP are involved in the control of many interconnected developmental and stress response regulatory networks, including competence, redox stress response, and motility.
Hoßmann, Jörn +3 more
core +3 more sources
Advanced Science, Volume 13, Issue 22, 17 April 2026.TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li +16 more
wiley +1 more source
Redox BiologyVascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the
Felipe Paredes +11 more
doaj +1 more source
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]
, 2020 To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju +13 more
core
Environmental stress responses in Lactococcus lactis [PDF]
, 1999 Bacteria can encounter a variety of physical conditions during their life. Bacterial cells are able to survive these (often adverse) conditions by the induction of specific or general protection mechanisms. The lactic acid bacterium Lactococcus lactis is
Kok, Jan, +2 more
core +3 more sources