Results 81 to 90 of about 152,432 (174)

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +1 more source

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small‐Molecule Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
Paridhi Gupta, Zheyi Hu, Li Zhu, Lora Hamuro   +3 more
wiley   +1 more source

Estimation of chloroplast macromolecular complex copy numbers and subunit stoichiometries during the Chlamydomonas reinhardtii cell cycle

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY An unbiased, quantitative view of biomolecules in a living cell is a prerequisite for accurate modeling approaches and informs our understanding of cellular metabolism at scale. In this work, we used the total protein approach (TPA), in which the total protein mass of a given proteomics sample is used as a calibrator for absolute protein ...
Stefan Schmollinger, Daniela Strenkert, Samuel O. Purvine, Carrie D. Nicora, Eric Soubeyrand, Gilles J. Basset, Sabeeha S. Merchant   +6 more
wiley   +1 more source

Protein degradation by a component of the chaperonin‐linked protease ClpP

Genes to Cells
AbstractIn cells, proteins are synthesized, function, and degraded (dead). Protein synthesis (spring) is important for the life of proteins. However, how proteins die is equally important for organisms. Proteases are secreted from cells and used as nutrients to break down external proteins. Proteases degrade unwanted and harmful cellular proteins.
Fumihiro Ishikawa, Michio Homma, Genzoh Tanabe, Takayuki Uchihashi   +3 more
openaire   +2 more sources

The Effect of the Lysine Acetylation Modification of ClpP on the Virulence of Vibrio alginolyticus

Molecules
Acetylation modification has become one of the most popular topics in protein post-translational modification (PTM) research and plays an important role in bacterial virulence.
Shi Wang, Yingying Jiang, Weijie Zhang, Yingzhu Wei, Xing Xiao, Zhiqing Wei, Xiaoxin Wen, Yuhang Dong, Jichang Jian, Na Wang, Huanying Pang   +10 more
doaj   +1 more source

Investigating The Role Of ClpP- And ClpX-Mediated Antimicrobial Resistance In Bacillus Anthracis

, 2020
The regulatory ATPase ClpX in Bacillus anthracis contributes to resistance against cell-wall active antibiotics. ClpX can function independently as a chaperone or together with ClpP to form the ClpXP protease.
Zou, Lang
core  

The ClpP N-Terminus Coordinates Substrate Access with Protease Active Site Reactivity

, 2016
Energy-dependent protein degradation machines, such as the Escherichia coli protease ClpAP, require regulated interactions between the ATPase component (ClpA) and the protease component (ClpP) for function.
Jen Bohon (59050), Mark R. Chance (196040), Stuart Licht (160989), Laura D. Jennings (2411464)   +3 more
core   +2 more sources

Role of ClpX and MsrA/B in the Oxidative and Cell Wall Stress Response in Bacillus anthracis Sterne

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Methionine sulfoxide reductase (msrA/B) is an oxidative response enzyme that reduces oxidized methionine residues to maintain protein function. Surprisingly, loss of MsrA/B does not increase sensitivity to hydrogen peroxide or paraquat‐induced oxidative stress in Bacillus anthracis Sterne.
Aeron B. Pennington, Salina Hona, Josey I. Austin, Kelsey C. Waite, Mikaela D. Stewart, Shauna M. McGillivray   +5 more
wiley   +1 more source

Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer

mBio
Clp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy, Laura Reinhardt, Elisa Liebhart, Mirita Franz-Wachtel, Boris Maček, Peter Sass, Heike Brötz-Oesterhelt   +6 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source