Results 101 to 110 of about 9,876 (190)

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Chemistry & Biology, 2011
ClpP is a cylindrical serine protease whose ability to degrade proteins is regulated by the unfoldase ATP-dependent chaperones. ClpP on its own can only degrade small peptides. Here, we used ClpP as a target in a high-throughput screen for compounds, which activate the protease and allow it to degrade larger proteins, hence, abolishing the specificity ...
Leung, Elisa, Datti, Alessandro, Cossette, Michele, Goodreid, Jordan, McCaw, Shannon E., Mah, Michelle, Nakhamchik, Alina, Ogata, Koji, El Bakkouri, Majida, Cheng, Yi-Qiang, Wodak, Shoshana J., Eger, Bryan T., Pai, Emil F., Liu, Jun, Gray-Owen, Scott, Batey, Robert A., Houry, Walid A.   +16 more
openaire   +2 more sources

Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]

, 2019
The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine, Gregory Boel, Olivier Danot, Victor de Lorenzo, Antoine Danchin   +1 more
core  

YoeB toxin is activated during thermal stress. [PDF]

, 2015
Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando, Hayes, Christopher S, Janssen, Brian D   +2 more
core   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Ein Konformationsschalter ist für die Funktionsweise der Protease ClpP verantwortlich

Angewandte Chemie, 2011
„Atmendes“ Protein: Die erste Struktur des Virulenzregulators und Hitzeschockproteins ClpP aus Staphylococcus aureus mit einem bisher nicht beobachteten komprimierten Zustand des ClpP-Fasses wird vorgestellt. Das Umschalten der Konformation in einer „Henkelregion“ am aktiven Zentrum führt zum Schließen der aktiven Zentren und Öffnen der äquatorialen ...
Geiger, Sebastian R., Böttcher, Thomas, Sieber, Stephan A., Cramer, Patrick   +3 more
openaire   +2 more sources

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, Volume 58, Issue 2, Page 601-618, March 2026.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase [PDF]

, 2013
There is rapidly mounting evidence that intracellular proteases in bacteria are compelling targets for antibacterial drugs. Multiple reports suggest that the human pathogen Mycobacterium tuberculosis and other actinobacteria may be particularly sensitive
Compton, Corey L., Sauer, Robert T., Schmitz, Karl R., Sello, Jason K.   +3 more
core   +1 more source

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX [PDF]

, 2015
The hexameric AAA+ ring of Escherichia coli ClpX, an ATP-dependent machine for protein unfolding and translocation, functions with the ClpP peptidase to degrade target substrates.
A Martin, Benjamin M Stinson, BM Stinson, DM Smith, G Thibault, GC Lander, GL Hersch, I Chen, JA Kenniston, JA Kenniston, JC Cordova, JG Nørby, JJ Lavinder, JW Taraska, Karl R Schmitz, M Sen, M-E Aubin-Tam, ME Matyskiela, MW Popp, R Beckwith, RA Maillard, RE Burton, Robert T Sauer, RT Sauer, SA Joshi, SE Glynn, TA Baker, Tania A Baker, TP Geladopoulos, UA Wojtyra, Vladimir Baytshtok, YI Kim, YI Kim   +32 more
core   +2 more sources

Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX [PDF]

, 2015
ATP-dependent protein remodeling and unfolding enzymes are key participants in protein metabolism in all cells. How these often-destructive enzymes specifically recognize target protein complexes is poorly understood.
Baker, Tania, Ling, Lorraine, Montaño, Sherwin P., Rice, Phoebe A., Sauer, Robert T.   +4 more
core   +1 more source