Results 101 to 110 of about 152,432 (174)

Conditional depletion of the chlamydomonas chloroplast ClpP protease activates nuclear genes involved in autophagy and plastid protein quality control [PDF]

, 2014
Plastid protein homeostasis is critical during chloroplast biogenesis and responses to changes in environmental conditions. Proteases and molecular chaperones involved in plastid protein quality control are encoded by the nucleus except for the catalytic
Pérez-Pérez, María Esther, Crespo, José L., Rochaix, J., Civic, N., Goodenough, U., Rochaix, Jean-David, Rusch, Jannette, Rusch, J., Esther Perez-Perez, M., Crèvecoeur, Michèle, Crèvecoeur, M., Civic, Natacha, Goodenough, Ursula, Pellegrini, Matteo, Schroda, Michael, Crespo, José Luis, Schroda, M., Rochaix, J.D., Mühlhaus, Timo, Schaad, Olivier, Schaad, O., Hemme, D., Luis Crespo, J., Ramundo, Silvia, Pellegrini, M., Rahire, M., Mühlhaus, T., Sommer, F., Sommer, Frederik, Ramundo, S., Casero, David, Casero, D., Rahire, Michèle, Hemme, Dorothea, Schroda M, Mühlhaus T, Crèvecoeur M, Sommer F, Crespo JL, Ramundo S, Pellegrini M, Goodenough U, Rusch J, Casero D, Rochaix JD, Perez-Perez ME, Hemme D, Rahire M, Civic N, Schaad O   +49 more
core   +1 more source

Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis. [PDF]

EMBO J, 2022
Kim L, Lee BG, Kim M, Kim MK, Kwon DH, Kim H, Brötz-Oesterhelt H, Roh SH, Song HK.   +8 more
europepmc   +1 more source

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment

Cell Reports Medicine
Summary: Inflammatory bowel disease (IBD) is an autoimmune disorder, and despite the availability of multiple Food and Drug Administration (FDA)-approved therapies, current clinical needs remain unmet. In this study, we find that caseinolytic protease P (
Jiangnan Zhang, Yunhan Jiang, Dongmei Fan, Zhiqiang Qiu, Xinlian He, Song Liu, Linjie Li, Zhengyi Dai, Lidan Zhang, Ziyi Shu, Lili Li, Hu Zhang, Tao Yang, Youfu Luo   +13 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure

, 2016
ATP-dependent Clp protease (ClpP), a highly conserved serine protease in vast bacteria, could be converted into a noncontrollable enzyme capable of degrading mature proteins in the presence of acyldepsipeptides (ADEPs).
Hualiang Jiang (19452), Xing Liu (221084), Jie Zhang (64655), Jianhua Gan (1493533), Cheng Luo (48047), Hongchuan Liu (2060263), Tengfeng Ni (2745787), Yinqiang Sun (2821539), Lefu Lan (345536), Yingyi Zhang (118046), Fei Ye (339913), Jiahui Li (646449), Ao Zhang (372387), Meining Wang (1763485), Hu Zhou (54222), Cai-Guang Yang (622949)   +15 more
core   +1 more source

Molecular Basis of ClpP Protease Activation by Small Molecules

The FASEB Journal, 2019
Bacterial ClpP is a highly conserved, self‐compartmentalizing, cylindrical serine protease required for maintaining cellular proteostasis. Acyldepsipeptides (ADEPs) and activators of self‐compartmentalized proteases (ACPs) are small molecules that cause the dysregulation and activation of ClpP, which leads to bacterial cell death ...
openaire   +1 more source

Molecular insights into the dynamic modulation of bacterial ClpP function and oligomerization by peptidomimetic boronate compounds

Scientific Reports
Bacterial caseinolytic protease P subunit (ClpP) is important and vital for cell survival and infectivity. Recent publications describe and discuss the complex structure–function relationship of ClpP and its processive activity mediated by 14 catalytic ...
Bruno Alves França, Sven Falke, Holger Rohde, Christian Betzel   +3 more
doaj   +1 more source

Structure characterization and mechanism of angiotensin I-converting enzyme (ACE) inhibitory peptides modified by plastein reaction derived from tiger nut (Cyperus esculentus)

Frontiers in Sustainable Food Systems
The development of peptides derived from plants, which have potential anti-angiotensin converting enzyme (ACE) activity and other bioactivities, are of scientific interest.
Junhua Shi, Zhuo Yang, Ming Xu, Guogang Zhao, Yawen Gao, Hongyan Zheng, Ji Feng   +6 more
doaj   +1 more source

Expression of type II toxin-antitoxin systems and ClpP protease of methicillin-resistant Staphylococcus aureus under thermal and oxidative stress conditions. [PDF]

Iran J Microbiol, 2021
Karimaei S, Kalani BS, Shahrokhi N, Mashhadi R, Pourmand MR.   +4 more
europepmc   +1 more source

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

Acta Biochimica et Biophysica Sinica
Currently, platinum agents remain the mainstay of chemotherapy for ovarian cancer (OC). However, cisplatin (DDP) resistance is a major reason for chemotherapy failure.
Kou Xinxin, Yang Xiaoxia, Zhao Zheng, Li Lei   +3 more
doaj   +1 more source