Results 71 to 80 of about 9,876 (190)

Purification of the Caseinolytic protease ClpP.

, 2022
The caseinolytic protease P (ClpP) is an essential protein for bacteria and bacterial derived organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it plays an important role in protein digestion. This protease is involved in essential processes such as, cellular regulatory mechanisms, protein homeostasis ...
Pedrós Manzanares, Laura, Brötz-Oesterhelt, Heike   +1 more
openaire   +1 more source

Role of ClpP in the Biogenesis and Degradation of RuBisCO and ATP Synthase in Chlamydomonas reinhardtii

Plants, 2019
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) associates a chloroplast- and a nucleus-encoded subunit (LSU and SSU). It constitutes the major entry point of inorganic carbon into the biosphere as it catalyzes photosynthetic CO2 fixation.
Wojciech Majeran, Katia Wostrikoff, Francis-André Wollman, Olivier Vallon   +3 more
doaj   +1 more source

Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP. [PDF]

Commun Biol
Abstract Bacterial AAA+ proteases are composed of a AAA+ partner (e.g. ClpC) and an associated peptidase (e.g. ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence. ClpC requires cooperation with adaptor proteins such as MecA for activation and complex formation with ClpP.
Azinas S, Wallden K, Katikaridis P, Jenne T, Schahl A, Mogk A, Carroni M.   +6 more
europepmc   +3 more sources

Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS

PROTEOMICS, Volume 26, Issue 5, Page 27-36, May 2026.
ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor, Austin Lipinski, Paul R. Langlais, Jacob C. Schwartz   +3 more
wiley   +1 more source

Protein degradation in bacteria: focus on the ClpP protease

Nippon Saikingaku Zasshi
Proteins in the cells are born (synthesized), work, and die (decomposed). In the life of a protein, its birth is obviously important, but how it dies is equally important in living organisms. Proteases secreted into the outside of cells are used to decompose the external proteins and the degradation products are taken as the nutrients.
Fumihiro, Ishikawa, Michio, Homma, Genzoh, Tanabe, Takayuki, Uchihashi   +3 more
openaire   +2 more sources

Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes

Microbiology Spectrum, 2022
Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant ...
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum   +18 more
doaj   +1 more source

Targeting the Mitochondrial Protease ClpP for Anticancer Therapy. [PDF]

J Med Chem
Xu Z, Pokushalov D, Kabir M, Lee Y, Chattopadhyay M, Jenkins EC, Choo C, Kaniskan HÜ, Germain D, Jin J.   +9 more
europepmc   +2 more sources

Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis [PDF]

, 2014
Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation is ...
Gygi, Steven P., Jedrychowski, Mark P., O'Brien, Kathryn, Park, Annie S., Pinkham, Jessica T., Raju, Ravikiran M., Rehren, German, Rubin, Eric J., Schnappinger, Dirk, Wei, Jun-Rong   +9 more
core   +3 more sources

Quality control of protein import into mammalian mitochondria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein, Laurie Lee‐Glover, Hilla Weidberg   +2 more
wiley   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source