Results 71 to 80 of about 152,432 (174)

Phylogenomics Clarifies Plastome Reduction and Phylogenetic Relationships in Monotropoideae

Ecology and Evolution, Volume 16, Issue 10, October 2026.
Phylogenetic Relationships of the Ericaceae Family. ML bootstrap/MP jackknife supported tree from Freudenstein et al. based on (A) nuclear loci, (B) plastid loci, (C) mitochondrial loci, and (D) nuclear+plastid datasets (E). Our combined nuclear + plastid parsimony tree for main groups.
Guocui Deng, Kaili Duan, Niyan Xiang, Feng Gao, Peng Zhan, Rui Shu, Qingsong Lin, Qing Zuo, Tao Yuan   +8 more
wiley   +1 more source

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]

, 2010
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Smith, H.E., Butler, R.E., Thole, J.E.R., Harders-Westerveen, S.F., Kierzek, A., Neyrolles, O., Estorninho, M., Stewart, G.R., Estorninho, M, Jelle Thole, Harders-Westerveen, J, Butler, RE, Graham R. Stewart, Jose Harders-Westerveen, Neyrolles, O, Hilde Smith, Thole, J, Rachel E. Butler, Smith, H, Kierzek, A, Olivier Neyrolles, Stewart, GR, Andrzej Kierzek, Megan Estorninho   +23 more
core   +1 more source

Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

Pharmacology Research & Perspectives, 2022
We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves   +16 more
doaj   +1 more source

Characterization of the First Complete Plastome of Zingiber emeiense: Insights Into Its Phylogenetic Position

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study assembled the first complete chloroplast genome of the endemic medicinal plant Zingiber emeiense, revealing its genomic structure and evolutionary features as well as clarifying its phylogenetic placement. It further provides valuable genomic resources for the conservation and taxonomic research of this endemic species.
Hualan Chen, Zhaofei Wang, Jinyong Ni, Qinxi Feng, Yue Liu, Lihui Jiang, Chao Song, Yanlin Zhu, Menghan Zhang, Qin Xie, Maoqin Xia, Honglei Li   +11 more
wiley   +1 more source

Role of ClpP in the Biogenesis and Degradation of RuBisCO and ATP Synthase in Chlamydomonas reinhardtii

Plants, 2019
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) associates a chloroplast- and a nucleus-encoded subunit (LSU and SSU). It constitutes the major entry point of inorganic carbon into the biosphere as it catalyzes photosynthetic CO2 fixation.
Wojciech Majeran, Katia Wostrikoff, Francis-André Wollman, Olivier Vallon   +3 more
doaj   +1 more source

Complete Chloroplast Genome of Nepeta griffithii and Comparative Genomics of 10 Nepeta Species

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study reports the first complete chloroplast genome of Nepeta griffithii and compares it with nine previously published Nepeta plastomes. Comparative analyses revealed conserved plastome structure, gene content, inverted repeat boundaries, codon usage, and SSR distribution across the genus, while identifying highly variable loci for future ...
Xinyi Li, Abdul Sammad, Sayed Afzal Shah, Jiahui Sun, Aman Karim, Bartholomew Yir‐erong, Xiaoxuan Tian, Abdullah   +7 more
wiley   +1 more source

Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors [PDF]

, 2019
The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence.
Gribbon, Philip, Winterhalter, Mathias, Windshügel, Björn, Elisa Sassetti, Sassetti, Elisa, Mathias Winterhalter, Philip Gribbon, Tammela, Päivi, Cruz, Cristina Durante, Durante Cruz, Cristina, Tammela, Paeivi, Windshuegel, Bjoern, Koen Augustyns, Päivi Tammela, Augustyns, Koen, Björn Windshügel, Cristina Durante Cruz, Durante Cruz, C., Tammela, P., Augustyns, K., Windshügel, B., Gribbon, P., Sassetti, E., Winterhalter, M.   +23 more
core   +2 more sources

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang, Abhijit Behera, Hannah J. Meyers, Tina Wang   +3 more
wiley   +1 more source

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Redox Biology
Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the
Felipe Paredes, Holly C. Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M. Crotty, Samantha M. Yeligar, Alvaro A. Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin   +11 more
doaj   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, Volume 59, Issue 9, September 2026.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source