Results 51 to 60 of about 5,899 (155)

Protein degradation in bacteria: focus on the ClpP protease

Nippon Saikingaku Zasshi
Proteins in the cells are born (synthesized), work, and die (decomposed). In the life of a protein, its birth is obviously important, but how it dies is equally important in living organisms. Proteases secreted into the outside of cells are used to decompose the external proteins and the degradation products are taken as the nutrients.
Fumihiro, Ishikawa, Michio, Homma, Genzoh, Tanabe, Takayuki, Uchihashi   +3 more
openaire   +2 more sources

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target [PDF]

Journal of Bacteriology, 2012
ABSTRACT Mycobacterium tuberculosis is a pathogen of major global importance. Validated drug targets are required in order to develop novel therapeutics for drug-resistant strains and to shorten therapy. The Clp protease complexes provide a means for quality control of cellular proteins; the proteolytic activity of ...
Juliane, Ollinger, Theresa, O'Malley, Edward A, Kesicki, Joshua, Odingo, Tanya, Parish   +4 more
openaire   +2 more sources

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

Pharmacology Research & Perspectives, 2022
We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves   +16 more
doaj   +1 more source

Complete Chloroplast Genome of Cardamine microzyga and Phylogenetic Analysis

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This study reports the first complete chloroplast genome of Cardamine microzyga, a perennial herb from mountainous southwestern China. The genome is 154,661 bp in length with a typical quadripartite structure and contains 129 genes. Comparative genomic analyses identified several hypervariable regions (e.g., trnS‐GCU, rrn4.5S, ycf1) as promising DNA ...
Yongming Fan, Yan Wu, Heng Zeng, Can Zhao, Chu Li, Le Chen, Jian Hu, Lingjun Li   +7 more
wiley   +1 more source

Role of ClpP in the Biogenesis and Degradation of RuBisCO and ATP Synthase in Chlamydomonas reinhardtii

Plants, 2019
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) associates a chloroplast- and a nucleus-encoded subunit (LSU and SSU). It constitutes the major entry point of inorganic carbon into the biosphere as it catalyzes photosynthetic CO2 fixation.
Wojciech Majeran, Katia Wostrikoff, Francis-André Wollman, Olivier Vallon   +3 more
doaj   +1 more source

Characterization of Aster lautureanus (Asteroideae, Asteraceae) Chloroplast Genome and Phylogenetic Insights

Ecology and Evolution, Volume 16, Issue 7, July 2026.
In this study, we first sequenced and characterized the complete chloroplast genome of Aster lautureanus and conducted comprehensive analyses of genome structure, codon usage, repeat sequences, phylogeny, and divergence time. ABSTRACT The genus Aster represents an important group of flowering plants with complex evolutionary relationships, yet genomic ...
Qiaoyu Zhang, Yuan Xu, Haoyu Zhang, Xiaoqing Yuan, Xiangyun Ji, Xinyue Zhang, Yan Zhang, Shoufu Gong, Zongli Chu, Zhenzhen Cheng   +9 more
wiley   +1 more source

Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment

Biomedicines, 2023
Transcription of the mitochondrial genome is essential for the maintenance of oxidative phosphorylation (OXPHOS) and other functions directly related to this unique genome.
Sabrina C. D. Daglish, Emily M. J. Fennell, Lee M. Graves   +2 more
doaj   +1 more source

The Complete Plastid Genome of Astrohibiscus caesius (Hibisceae, Malvaceae) and Its Phylogenetic Placement

Ecology and Evolution, Volume 16, Issue 7, July 2026.
The complete plastid genome of Astrohibiscus caesius has a typical quadripartite structure (161,092 bp) and encodes 112 unique genes with an AT‐rich bias. Phylogenomic analysis confirms that Hibiscus is polyphyletic and Astrohibiscus forms a distinct lineage outside all major Hibiscus clades, providing whole‐plastome evidence supporting this monotypic ...
Rushan Yan, Furrukh Mehmood, Liya Guo, Mahpara Akhtar, Abdul Sammad, Jiahui Sun, Parviz Heidari, Abdullah, Xiaoxuan Tian   +8 more
wiley   +1 more source