Results 111 to 120 of about 7,556 (201)

Multi‐Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome

Journal of Periodontal Research, Volume 60, Issue 12, Page 1237-1253, December 2025.
This multi‐omics study integrates shotgun metagenomics and NMR metabolomics to reveal coordinated microbial and metabolic signatures of periodontitis across the oral–gut axis. Non‐surgical periodontal therapy partially restored ecological and functional balance, supporting oral health as a modifiable driver of systemic microbial homeostasis.
Giacomo Baima, Shareef Dabdoub, Vivek Thumbigere‐Math, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Leonardo Tenori, Linda Fantato, Alessia Vignoli, Mario Romandini, Ilario Ferrocino, Mario Aimetti   +10 more
wiley   +1 more source

Differential effects of age and sex on tau pathology propagation in the htau mouse model: A neuropathological and proteomic study

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Aging is the main risk factor for Alzheimer's disease (AD), acting through still poorly understood mechanisms. AD is associated with the development of a tau pathology, a hallmark lesion propagating in the brain along neuroanatomically connected pathways.
Andreea‐Claudia Kosa, Lidia Lopez‐Gutierrez, Kunie Ando, Emilie Doeraene, Emmanuel Aydin, Hinde Lasri, Alain Wathelet‐Depauw, Karlien Pieters, David Van Morckhoven, Virginie Imbault, Christine Dubois, Xavier Bisteau, Basile Stamatopoulos, Mariana Igoillo‐Esteve, Jean‐Pierre Brion, Karelle Leroy   +15 more
wiley   +1 more source

CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation

Biomolecules
The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia.
Jana Key, Suzana Gispert, Arvind Reddy Kandi, Daniela Heinz, Andrea Hamann, Heinz D. Osiewacz, David Meierhofer, Georg Auburger   +7 more
doaj   +1 more source

Mechanochemical basis of protein degradation by a double-ring AAA+ machine [PDF]

, 2014
Molecular machines containing double or single AAA+ rings power energy-dependent protein degradation and other critical cellular processes, including disaggregation and remodeling of macromolecular complexes.
A Martin, A Martin, A Roll-Mecak, Adrian O Olivares, AF Neuwald, Andrew R Nager, AR Nager, BM Stinson, C Zhao, CM Farrell, DA Dougan, DH Wolf, DM Smith, E Gur, E Gur, EM De La Cruz, EU Weber-Ban, F Guo, F Wang, J Hinnerwisch, J Liu, JA Kenniston, JC Cordova, JM Flynn, JM Miller, JW Kerssemakers, M Carrion-Vazquez, M Sen, MC Bewley, ME Aubin-Tam, ME Aubin-Tam, MR Maurizi, ND Werbeck, Ohad Iosefson, P Koodathingal, R Grimaud, RA Maillard, Robert T Sauer, RT Sauer, S Cranz-Mileva, SD Moore, SE Glynn, SM Doyle, T Ogura, Tania A Baker, W Kress, Y Katayama, YI Kim, Z Maglica   +48 more
core   +1 more source

Genomic Characterisation of Limosilactobacillus fermentum CRL2085 Unveiling Probiotic Traits for Application in Cattle Feed

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
A comprehensive genomic and phenotypic analysis of Limosilactobacillus fermentum CRL2085 revealed key probiotic and nutritional traits supporting its safe application in cattle feed. The strain harbors genes for stress tolerance, adhesion, exopolysaccharide production, and B‐vitamin biosynthesis, and efficiently metabolizes plant‐derived carbohydrates,
Cecilia M. Aristimuño Ficoseco, Daniele Chieffi, Marco Montemurro, Annarita Bavaro, Carlo G. Rizzello, Maria E. F. Nader‐Macias, Silvina Fadda, Francesca Fanelli, Vincenzina Fusco, Graciela M. Vignolo   +9 more
wiley   +1 more source

Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease [PDF]

, 2011
In the AAA+ ClpXP protease, ClpX uses the energy of ATP binding and hydrolysis to unfold proteins before translocating them into ClpP for degradation.
Baker, Tania, Nager, Andrew Ross, Sauer, Robert T.   +2 more
core   +1 more source

Pressure‐dependent adaptation strategies implied by the dissimilatory iron reducer Orenia metallireducens Z6

mLife, Volume 5, Issue 1, Page 122-125, February 2026.
Shuyi Li, Jiahao Pei, Jiasong Fang, Rulong Liu, Yuli Wei, Xianyu Huang, Guang Yang, Min Liu, Qin Lin, Robert R. Sanford, Hongbo Shao, Yongguang Jiang, Yidan Hu, Zhou Jiang, Qi Feng, Yu He, Chenxi Zhang, Yizhou Fan, Yiran Dong, Liang Shi   +19 more
wiley   +1 more source

Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. [PDF]

, 2020
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients
Ahmed, Mohamed Sohail, Ambati, Aditya, Inayathullah, Mohammed, Mallajosyula, Venkata Vamsee Aditya, Pothineni, Venkata Raveendra, Potula, Hari-Hara SK, Rajadas, Jayakumar, Sridharan, Brindha   +7 more
core  

Spatio-temporal influence of tundra snow properties on Ku-band (17.2 GHz) backscatter [PDF]

, 2015
During the 2010/11 boreal winter, a distributed set of backscatter measurements was collected using a ground-based Ku-band (17.2 GHz) scatterometer system at 26 open tundra sites.
Derksen, Chris, Dugauy, Claude, Gunn, Grant, Kasurak, Andrew, Kelly, Richard, King, Joshua, Rutter, Nick, Watts, Tom   +7 more
core   +1 more source

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation [PDF]

, 2009
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (leaves 67-71).Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in ...
Shin, Yongdae
core