Results 91 to 100 of about 4,851 (193)

Microbial responses to emerging technologies in fermented dairy processing: Implications for product development

International Journal of Dairy Technology, Volume 79, Issue 3, July‐September 2026.
Emerging processing technologies can do more than inactivate microorganisms; under controlled sublethal conditions, they reprogram microbial physiology and metabolism. This review highlights the underlying mechanisms, technological opportunities, and current challenges for designing next‐generation fermented dairy products with improved functionality ...
Sepehrdad Dehghani, Ramila Cristiane Rodrigues, Vitor Emanuel Máximo Santos, Pedro Henrique Campelo, Evandro Martins   +4 more
wiley   +1 more source

Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation [PDF]

Protein Science, 2019
AbstractIGF‐motif loops project from the hexameric ring of ClpX and are required for docking with the self‐compartmentalized ClpP peptidase, which consists of heptameric rings stacked back‐to‐back. Here, we show that ATP or ATPγS support assembly by changing the conformation of the ClpX ring, bringing the IGF loops closer to each other and allowing ...
Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.   +3 more
openaire   +4 more sources

Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria [PDF]

, 2017
Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyrias, eight forms of which have been described. The genetic penetrance of the porphyrias is clinically variable, underscoring the role of additional ...
Kardon, Julia, Phillips, John, Kannengiesser, Caroline, Kardon, Julia R., Paw, Barry H., Tania A. Baker, Paw, Barry, Sarah Ducamp, Baker, Tania, Kafina, Martin D., Yien, Yvette, Julia R. Kardon, Caroline Kannengiesser, van der Vorm, Lisa N., Bergonia, Hector A., Phillips, John D., Ducamp, Sarah, Yien, Yvette Y., Karim, Zoubida, Lisa N. van der Vorm, Bergonia, Hector, Zoubida Karim, John D. Phillips, Kafina, Martin, Hector A. Bergonia, Hervé Puy, Gaël Nicolas, Gouya, Laurent, Nicolas, Gaël, Laurent Gouya, Manceau, Hana, Puy, Hervé, van Der Vorm, Lisa, Yvette Y. Yien, Barry H. Paw, Hana Manceau, Martin D. Kafina   +36 more
core   +1 more source

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

Asian Journal of Andrology
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins. The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix peptidase X
Hai-Wei Feng, Yu Zhao, Yan-Ling Gao, Dong-Teng Liu, Li-Jun Huo   +4 more
doaj   +1 more source

Oxidative Stress and Diminished Mitochondrial Proteostatic Reserve Are Linked to Enhanced mtUPR Initiation in Aged Mouse Muscle

Aging Cell, Volume 25, Issue 6, June 2026.
Aged mouse skeletal muscle exhibits greater mtUPR transcriptional initiation following repeated physical stress than young mice, coinciding with reduced mitochondrial proteostatic reserve and heightened oxidative burden. We implicate a mtROS‐JNK‐CHOP axis as a contributor to the enhanced response.
Grant R. Laskin, Baylah R. Mazonson, LaDora V. Thompson   +2 more
wiley   +1 more source

Human Mitochondrial ClpP Is a Stable Heptamer That Assembles into a Tetradecamer in the Presence of ClpX [PDF]

Journal of Biological Chemistry, 2005
The functional form of ClpP, the proteolytic component of ATP-dependent Clp proteases, is a hollow-cored particle composed of two heptameric rings joined face-to-face forming an aqueous chamber containing the proteolytic active sites. We have found that isolated human mitochondrial ClpP (hClpP) is stable as a heptamer and remains a monodisperse species
Sung Gyun, Kang, Mariana N, Dimitrova, Joaquin, Ortega, Ann, Ginsburg, Michael R, Maurizi   +4 more
openaire   +2 more sources

Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision [PDF]

, 2019
In all living cells, molecular chaperones are essential for facilitating folding and unfolding of proteins. ClpX is a highly conserved ATP-dependent chaperone that besides functioning as a classical chaperone can associate with ClpP to form the ClpXP ...
Frees, Dorte, Jensen, Camilla, Bæk, Kristoffer T., Thalsø-Madsen, Ida, Fosberg, Marie J.   +4 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, Volume 600, Issue 10, Page 1444-1474, May 2026.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Selectivity among Anti-� Factors by Mycobacterium tuberculosis ClpX Influences Intracellular Levels of Extracytoplasmic Function � Factors

, 2019
Extracytoplasmic function Ï factors that are stress inducible are often sequestered in an inactive complex with a membrane-associated anti-Ï factor. Mycobacterium tuberculosis membrane-associated anti-Ï factors have a small, stable RNA gene A (ssrA ...
Gopal, B, Nair, RK, Kaur, P, Nandicoori, VK, Lele, DS, Joshi, AC   +5 more
core   +1 more source

Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS

PROTEOMICS, Volume 26, Issue 5, Page 27-36, May 2026.
ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor, Austin Lipinski, Paul R. Langlais, Jacob C. Schwartz   +3 more
wiley   +1 more source