Results 71 to 80 of about 4,851 (193)
ChemBioChem, Volume 27, Issue 18, 28 September 2026.Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Linwei Yang +3 more
wiley +1 more source
The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
Cells, 2022 In the matrix of bacteria/mitochondria/chloroplasts, Lon acts as the degradation machine for soluble proteins. In stress periods, however, proteostasis and survival depend on the strongly conserved Clp/Hsp100 family. Currently, the targets of ATP-powered
Georg Auburger, Jana Key, Suzana Gispert
doaj +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, Volume 13, Issue 53, 24 September 2026.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Investigation of novel degradation motifs for ClpX/P protease in Streptococcus mutans
, 2022 The protein quality control network plays a significant role in maintaining the proteome composition and proper cell function. AAA+ proteases are an important component of this protein quality network. Similar to other bacteria, these AAA+ proteases play
Gurung, Vivek
core
Cell Reports, 2015 In the axial channels of ClpX and related hexameric AAA+ protein-remodeling rings, the pore-1 loops are thought to play important roles in engaging, mechanically unfolding, and translocating protein substrates. How these loops perform these functions and
Ohad Iosefson +3 more
doaj +1 more source
Interferometric Synthetic Aperture Radar (InSAR) for Monitoring Seasonal Snow
Water Resources Research, Volume 62, Issue 9, September 2026.Abstract Interferometric Synthetic Aperture Radar (InSAR) offers a potential pathway for measuring seasonal snow water equivalent (SWE) and snow depth at spatial and temporal scales needed for basin‐scale hydrology. First proposed for seasonal snow more than 25 years ago, InSAR uses repeat‐pass radar phase differences to estimate changes in SWE or ...
Jack Tarricone +17 more
wiley +1 more source
Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding
eLife, 2020 Mitochondria control the activity, quality, and lifetime of their proteins with an autonomous system of chaperones, but the signals that direct substrate-chaperone interactions and outcomes are poorly understood.
Julia R Kardon +3 more
doaj +1 more source
Nature Communications, 2023 Bacteriophages (phages) are the most abundant biological entities on Earth, exerting a significant influence on the dissemination of bacterial virulence, pathogenicity, and antimicrobial resistance.
Mohammed A. Thabet +2 more
doaj +1 more source
Microorganisms, 2023 Antibiotic resistance is a significant and pressing issue in the medical field, as numerous strains of infectious bacteria have become resistant to commonly prescribed antibiotics.
Darya V. Poshvina +2 more
doaj +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source