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Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

open access: yesAmerican Journal of Transplantation, 2014
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc ...
Li, P.   +7 more
exaly   +2 more sources
Some of the next articles are maybe not open access.

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Human immune reactivity of GGTA1/CMAH/A3GALT2 triple knockout Yucatan miniature pigs

Transgenic Research, 2021
Jeongwoong Lee   +2 more
exaly  

Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute

Biochemical and Biophysical Research Communications, 2018
Ute Krengel   +2 more
exaly  

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