Results 161 to 170 of about 3,073 (171)

Transplantation Beyond Species: The Present and Future of Xenotransplantation. [PDF]

Sao Paulo Med J
Caneo LF, Thomé T, Pêgo-Fernandes PM.
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Human anti‐α‐fucose antibodies are xenoreactive toward GGTA1/CMAH knockout pigs

Xenotransplantation, 2020
AbstractProgress has been made in overcoming antibody‐mediated rejection of porcine xenografts by deleting pig genes that produce unique carbohydrate epitopes. Pigs deficient in galactose α‐1,3 galactose (gene modified: GGTA1) and neu5Gc (gene modified: CMAH) have reduced levels of human antibody binding.
Christopher Burlak, R. Travis Taylor, Zheng Yu Wang, A. Joseph Tector   +3 more
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Cmah deficiency blunts cellular senescence in adipose tissues and improves whole‐body glucose metabolism in aged mice

Geriatrics & Gerontology International, 2023
AimCytidine monophosphate‐N‐acetylneuraminic acid (Neu5Ac) hydroxylase (Cmah) is an enzyme, which converts Neu5Ac to the sialic acid Neu5Gc. Neu5Gc is thought to increase inflammatory cytokines, which are, in part, produced in senescent cells of adipose tissues.
Reo Takeda, Ayaka Tabuchi, Yudai Nonaka, Ryotaro Kano, Mizuki Sudo, Yutaka Kano, Daisuke Hoshino   +6 more
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Effect of CHO cell line constructed with CMAH gene-directed integration on the recombinant protein expression

International Journal of Biological Macromolecules
Chinese hamster ovary (CHO) cells are the most widely used platform for recombinant therapeutic protein (RTP) production. Traditionally, the development of CHO cell lines has mainly depended on random integration of transgenes into the genome, which is not conducive to stable long-term expression.
Xiang-Xiang, Cao, Jing-Jia, Yuan, Zhi-Yuan, Bai, Min, Zhang, Yi-Fei, Yun, Xiao-Yin, Wang, Chun-Liu, Mi, Qiu-Li, Sun, Shao-Lei, Geng, Tian-Yun, Wang   +9 more
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Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

Acta Biomaterialia, 2018
Bioprosthetic heart valves (BHVs) originating from pigs are extensively used for heart valve replacement in clinics. However, recipient immune responses associated with chronic calcification lead to structural valve deterioration (SVD) of BHVs. Two well-characterized epitopes on porcine BHVs have been implicated in SVD, including galactose-α1,3 ...
Runjie, Zhang, Ying, Wang, Lei, Chen, Ronggen, Wang, Chu, Li, Xiaoxue, Li, Bin, Fang, Xueyang, Ren, Miaomiao, Ruan, Jiying, Liu, Qiang, Xiong, Lining, Zhang, Yong, Jin, Manling, Zhang, Xiaorui, Liu, Lin, Li, Qiang, Chen, Dengke, Pan, Rongfeng, Li, David K C, Cooper, Haiyuan, Yang, Yifan, Dai   +21 more
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Intrinsically Hyperactive and Hyperproliferative CD8+ T Cells In Cmah-/- Mice as a Model of Human Gene Transfer Responses.

Blood, 2010
Abstract Abstract 3773 Adeno-Associated Virus is a popular gene transfer vector that successfully treats many genetic diseases in animal models, yet has limited proof of efficacy in humans. While experimental animals have been useful in predicting vector dosing, they failed to provide a model for human T cell responses to ...
George Buchlis, Federico Mingozzi, Paula Campos Soto, Oliver Pearce, Daniel J. Hui, Ajit P. Varki, Katherine A. High   +6 more
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Immunophenotyping of GGTA1/CMAH KO Pig Renal Microvascular Endothelial Cells.

Transplantation, 2014
Z. Wang, C. Burlak, J. Estrada, P. Li, M. Tector, A. Tector   +5 more
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Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase (CMAH)

2014
Anne K. Bergfeld, Ajit Varki
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Reducing Immunogenicity of Porcine Bioprosthetic Heart Valves via GGTA1/β4GalNT2/CMAH Gene Targeting

Transplantation, 2018
Runjie Zhang, Ying Wang, Lei Chen, Chu Li, Xiaoxue Li, Ronggen Wang, Bin Fang, Xueyang Ren, Miaomiao Ruan, Jiying Liu, Qiang Xiong, Lining Zhang, Yong Jin, Manling Zhang, Xiaorui Liu, Lin Li, Lisha Mou, Rongfeng Li, Cooper DKC, Haiyuan Yang, Yifan Dai   +20 more
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Du CHAMR au CMAH: dix ans de colloques romands

1981
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