Results 111 to 120 of about 26,517 (143)

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Nature Communications
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability.
Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown, Michael J. Emanuele   +7 more
doaj   +1 more source

Biological roles of DExH RNA helicase, RHAU [PDF]

, 2007
In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes

Biology Direct, 2012
Background In eukaryotes, the CMG (CDC45, MCM, GINS) complex containing the replicative helicase MCM is a key player in DNA replication. Archaeal homologs of the eukaryotic MCM and GINS proteins have been identified but until recently no homolog of the ...
Makarova Kira S, Koonin Eugene V, Kelman Zvi   +2 more
doaj   +1 more source

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Nature Communications
The eukaryotic replisome, which consists of the CDC45-MCM2-7-GINS (CMG) helicase, replicative polymerases, and several accessory factors, sometimes encounters proteinaceous obstacles that threaten genome integrity.
Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson   +15 more
doaj   +1 more source

The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo

Nature Communications
We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for differential gene expression in cells produced by asymmetric cell divisions in C. elegans. We found that the C.
Nadin Memar, Ryan Sherrard, Aditya Sethi, Carla Lloret Fernandez, Henning Schmidt, Eric J. Lambie, Richard J. Poole, Ralf Schnabel, Barbara Conradt   +8 more
doaj   +1 more source

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in <i>Caenorhabditis elegans</i>. [PDF]

Science, 2023
Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM.   +7 more
europepmc   +1 more source

MCM5 UFMylation regulates replication origin firing and fork progression

The EMBO Journal
Modification with UFM1 (UFMylation) is essential for cell proliferation, but its precise mechanism of action is unclear. Furthermore, the UFMylation pathway has been associated with microcephalic primordial dwarfism (MPD) disorders, and mutations ...
Zheng Li, Xingxuan Wu, Liu Liu, Shaohong Rao, Yanting Liao, Mengting Liu, Bin Peng, Qiongdan Zhang, Yisui Xia, Yuanliang Zhai, Shunichi Takeda, Xingzhi Xu   +11 more
doaj   +1 more source

Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis. [PDF]

Sci Adv, 2023
Zhang W, Tang M, Wang L, Zhou H, Gao J, Chen Z, Zhao B, Zheng P.   +7 more
europepmc   +1 more source

Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome. [PDF]

Nucleic Acids Res, 2022
Oki K, Nagata M, Yamagami T, Numata T, Ishino S, Oyama T, Ishino Y.   +6 more
europepmc   +1 more source