Results 121 to 130 of about 26,517 (143)

EHA2024 Hybrid Congress

HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +1 more source

Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability

Nature Communications
Trinucleotide repeats, including Friedreich’s ataxia (GAA)n repeats, become pathogenic upon expansions during DNA replication and repair. Here, we show that deficiency of the essential replisome component Mcm10 dramatically elevates (GAA)n repeat ...
Chiara Masnovo, Zohar Paleiov, Daniel Dovrat, Laurel K. Baxter, Sofia Movafaghi, Amir Aharoni, Sergei M. Mirkin   +6 more
doaj   +1 more source

Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer

Experimental Hematology & Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year overall survival (OS) rate of approximately 12%. More than 90% of PDAC patients harbor oncogenic mutations in the Kirsten rat sarcoma viral homolog (KRAS) gene.
Jeffrey Xiao, Joshua Kim, Brandon Park, David J. Baylink, Cedric Kwon, Victoria Tran, Scott Lee, Kevin Codorniz, Laren Tan, Pamela Lobo Moreno, Amy Schill-Depew, Saied Mirshahidi, David De Semir, Diana Hanna, Kiran Naqvi, Huynh Cao, Chien-Shing Chen, Joanne Xiu, Heinz-Josef Lenz, Hamid Mirshahidi, Mark E Reeves, Yi Xu   +21 more
doaj   +1 more source

Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation

Nature Communications
DNA replication initiation requires local melting of fully base-paired DNA for a helicase to gain a foothold and initiate processive DNA unwinding. In eukaryotes and archaea, the helicase engine is the hexameric ring minichromosome maintenance (MCM ...
Sanaz Rasouli, Alexander Myasnikov, Eric J. Enemark   +2 more
doaj   +1 more source

Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome

The EMBO Journal
During DNA replication, the DNA polymerases Pol δ and Pol ε utilise the ring-shaped sliding clamp PCNA to enhance their processivity. PCNA loading onto DNA is accomplished by the clamp loaders RFC and Ctf18-RFC, which function primarily on the lagging ...
Emma E Fletcher, Morgan L Jones, Joseph T P Yeeles   +2 more
doaj   +1 more source

p68 RNA helicase - identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts [PDF]

, 2014
The human p68 protein is an RNA-dependent ATPase and RNA helicase which was first identified because of its immunological cross-reaction with a viral RNA helicase, simian virus 40 large T antigen.
Jamieson, DJ, Lane, DP, MacNeill, Stuart Andrew, McPheat, J, Southgate, J, Iggo, RD   +5 more
core  

Data from Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

<div>Abstract<p>The human CMG helicase (Cdc45-MCM-GINS) is a novel target for anticancer therapy. Tumor-specific weaknesses in the CMG are caused by oncogene-driven changes that adversely affect CMG function, and CMG activity is required for recovery from replicative stresses such as chemotherapy.
Mark G. Alexandrow, Damon R. Reed, Nicholas J. Lawrence, Harshani R. Lawrence, Renan B. Ferreira, Darcy L. Welch, Xingju Luo, Kendall C. Craig, Shengyan Xiang   +8 more
openaire   +1 more source

Cdt1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis. Ratnayeke et al.

Image data for manuscript submitted to Molecular Cell, Ratnayeke et al, "Cdt1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis ...
Meyer, T
core   +1 more source

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction. [PDF]

Int J Mol Sci, 2020
Denkiewicz-Kruk M, Jedrychowska M, Endo S, Araki H, Jonczyk P, Dmowski M, Fijalkowska IJ.   +6 more
europepmc   +1 more source

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.

Cell Rep
Maric M, Mukherjee P, Tatham MH, Hay R, Labib K.   +4 more
europepmc   +1 more source