Results 121 to 130 of about 2,048 (142)

Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation

Nature Communications
DNA replication initiation requires local melting of fully base-paired DNA for a helicase to gain a foothold and initiate processive DNA unwinding. In eukaryotes and archaea, the helicase engine is the hexameric ring minichromosome maintenance (MCM ...
Sanaz Rasouli, Alexander Myasnikov, Eric J. Enemark   +2 more
doaj   +1 more source

Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome

The EMBO Journal
During DNA replication, the DNA polymerases Pol δ and Pol ε utilise the ring-shaped sliding clamp PCNA to enhance their processivity. PCNA loading onto DNA is accomplished by the clamp loaders RFC and Ctf18-RFC, which function primarily on the lagging ...
Emma E Fletcher, Morgan L Jones, Joseph T P Yeeles   +2 more
doaj   +1 more source

The mechanism of DNA unwinding by the eukaryotic replicative helicase.

, 2020
Accurate DNA replication is tightly regulated in eukaryotes to ensure genome stability during cell division and is performed by the multi-protein replisome.
Hasan Yardimci (8128839), Hazal B Kose (8128830), Daniel R Burnham (8265849), Rebecca B Hoyle (8265852)   +3 more
core  

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment

, 2016
The CMG (Cdc45, MCM, GINS) helicase is required for cellular proliferation and functions to unwind double-stranded DNA to allow the replication machinery to duplicate the genome. Cancer cells mismanage helicase activation through a variety of mechanisms,
Bryant, Victoria
core  

Data from Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

<div>Abstract<p>The human CMG helicase (Cdc45-MCM-GINS) is a novel target for anticancer therapy. Tumor-specific weaknesses in the CMG are caused by oncogene-driven changes that adversely affect CMG function, and CMG activity is required for recovery from replicative stresses such as chemotherapy.
Mark G. Alexandrow, Damon R. Reed, Nicholas J. Lawrence, Harshani R. Lawrence, Renan B. Ferreira, Darcy L. Welch, Xingju Luo, Kendall C. Craig, Shengyan Xiang   +8 more
openaire   +1 more source

Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation

, 2016
Tumorigenesis is a multifaceted set of events consisting of the deregulation of several cell-autonomous and tissue microenvironmental processes that ultimately leads to the acquisition of malignant disease.
Nepon-Sixt, Brook Samuel
core  

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.

Cell Rep
Maric M, Mukherjee P, Tatham MH, Hay R, Labib K.   +4 more
europepmc   +1 more source

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase. [PDF]

Mol Cell, 2016
Villa F, Simon AC, Ortiz Bazan MA, Kilkenny ML, Wirthensohn D, Wightman M, Matak-Vinkovíc D, Pellegrini L, Labib K.   +8 more
europepmc   +1 more source

Rare genetic diseases associated with G-quadruplex-induced replication stress. [PDF]

Commun Biol
Herr LM, Mukhopadhyay S, Anderson OM, Couch TH, Jones CM, Brosh RM, Rossi M.   +6 more
europepmc   +1 more source

An updated view on lagging strand DNA replication: implications for the replication stress response. [PDF]

Cell Cycle
Martín-Rufo R, Lecona E.
europepmc   +1 more source