Results 131 to 140 of about 26,517 (143)

CDT1 acts with the replisome to remodel replication forks. [PDF]

Sci Adv
Hathaway C, Le T, Hatoyama Y, Kanemaki M, Dungrawala H.   +4 more
europepmc   +1 more source

A new perspective on ATR's role in translesion synthesis. [PDF]

Genes Dev
Lindsey-Boltz LA, Sancar A.
europepmc   +1 more source

Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. [PDF]

Nat Commun
Noguchi Y, Saleh A, Schneider S, Ivanova ME, Chen ZA, Ranjha L, Aramayo R, Tognetti S, Faull SV, Rappsilber J, Speck C.   +10 more
europepmc   +1 more source

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication [PDF]

Science, 2014
Chromosome replication is initiated by a universal mechanism in eukaryotic cells, involving the assembly and activation at replication origins of the CMG (Cdc45-MCM-GINS) DNA helicase, which is essential for the progression of replication forks ...
Karim Labib, Giacomo De Piccoli, Timurs Maculins   +2 more
exaly   +7 more sources

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Optimizing CMG helicase and CMG-dependent replication assays by designing DNA fork substrates and choosing nucleotide analogues for helicase preloading

Methods in Enzymology, 2022
The replication machinery that synthesizes new copies of chromosomal DNA is located at the junction where double-stranded DNA is separated into its two strands. This replication fork DNA structure is at the heart of most assays involving DNA helicases.
Mike E O'Donnell
exaly   +3 more sources

Disorders in the CMG helicase complex increase the proliferative capacity and delay chronological aging of budding yeast [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research
The replication of DNA requires specialized and intricate machinery. This machinery is known as a replisome and is highly evolutionarily conserved, from simple unicellular organisms such as yeast to human cells.
Mateusz Mołoń, Adrianna Skoneczna, Karolina Stepien   +2 more
exaly   +3 more sources

Single-Molecule Real-Time Visualization of DNA Unwinding by CMG Helicase

Journal of Visualized Experiments
Faithful genome duplication is essential for preserving the genetic stability of dividing cells. DNA replication is carried out during the S phase by a dynamic complex of proteins termed the replisome. At the heart of the replisome is the CDC45-MCM2-7-GINS (CMG) helicase, which separates the two strands of the DNA double helix such that DNA polymerases
Cameron, McClymont, Karolina, Chabowska, Sherry, Xie, May Thu, Kyaw, Hasan, Yardimci   +4 more
openaire   +2 more sources

Structure and Activity of the Cdc45-Mcm2–7-GINS (CMG) Complex, the Replication Helicase

2016
Highly efficient unwinding of double-stranded DNA is an essential prerequisite for duplication of the genetic material. In eukaryotes this process is catalysed by the CMG (Cdc45-Mcm2–7-GINS) complex, which is composed by 11 proteins: the Cdc45 replication factor, the hetero-hexameric Mcm2–7 and the tetrameric GINS complex.
Medagli, Barbara, Di Crescenzio, Patrizia, De March, Matteo, Onesti, Silvia   +3 more
openaire   +2 more sources

CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle

EMBO Reports, 2021
Karim Labib, Georges Lacaud, Fabrizio Villa   +2 more
exaly  

CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

Proceedings of the National Academy of Sciences of the United States of America, 2014
Roxana E Georgescu, Lance D Langston, Olga Yurieva   +2 more
exaly