Results 71 to 80 of about 86,048 (164)

Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events

WIREs RNA, Volume 15, Issue 1, January/February 2024.
Not5 ribosome binding ensures co‐translational organellar targeting and protein assembly. Prolonged ribosome pausing leading to post‐translocation ribosomes with empty A and E sites allows Not5 ribosome binding. This Not5 ribosome binding is key for co‐translational events such as organellar targeting or assembly of proteins.
Martine A. Collart, Léna Audebert, Martin Bushell   +2 more
wiley   +1 more source

Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. [PDF]

, 2019
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the
Babu, Balázs, Behrends, Benjamini, Buvall, Calderone, Caposio, Cen, Chatr-Aryamontri, Collins, Davis, Dietz, Dolan, Elias, Elias, Eng, Fabregat, Fielding, Fielding, Finn, Francis, Gallegos, Gatherer, Goodrum, Haas, Han, Higa, Hsu, Huang, Huttlin, Huttlin, Huttlin, Isomura, Jelcic, Keyvani Chahi, Kim, Koshizuka, Krishna, Krishna, Krogh, Kurochkina, Käll, Lian, Licata, Maryati, McAlister, McGeehan, McSharry, Medvar, Meissner, Menzies, Mocarski, Mocarski Jr, Nathans, Nemčovičová, Ngoenkam, Nichols, Nightingale, Omoto, Omoto, Orchard, Park, Pery, Rawlinson, Reeves, Rusinova, Salemi, Savaryn, Schwanhäusser, Schwartz, Seirafian, Shannon, Smith, Sowa, Stanton, Stanton, Stanton, Stern-Ginossar, Tanaka, Terhune, van der Wal, Vizcaíno, Wang, Weekes, Weekes, Wiertz, Wilkinson, Wu, Yi   +88 more
core   +8 more sources

Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes

Nature Communications
Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu, Wenrong Tao, Shuang Wu, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang, Falong Lu, Keliang Wu   +11 more
doaj   +1 more source

Ectopic Expression of Human Herpesvirus 1 Thymidine Kinase Induces Male Infertility [PDF]

, 2016
The herpesvirus family comprises several widespread infectious pathogens. They infect a variety of animal hosts, including humans and cause complex clinical outcomes.
Cai, Li‐yi, Chen, Mo, Kato, Takako, Kato, Yukio   +3 more
core   +2 more sources

Mtail-Seq For Pan2/3, Caf1A/B (Cnot7/8) Kd Hela Samples (Internal Id: Ms121)

, 2018
mTAIL-seq, MiSeq run (internal ID: ms121) spkN, spk8, spk16, spk32, spk64, spk118, spk128 spike-ins NC2 (siCont), 232 (siPAN2/3), 783 (siCAF1a/b or siCNOT7/8) samples This dataset contains cluster intensities of fluorescence signals that are repacked as an HDF5 formatted file.
Park, Joha, Yi, Hyerim, Kim, V. Narry
openaire   +1 more source

Spleen transcriptomics reveals breed-specific mechanisms of Salmonella resistance under heat stress in chickens

Poultry Science
Heat stress and Salmonella infection are two major challenges threatening poultry health and productivity. Native breeds generally show stronger resistance than commercial lines, but the molecular mechanisms underlying this advantage remain unclear. This
Yaping Wang, Qiao Wang, Zixuan Wang, Xiang Li, Mohamed Shafey Elsharkawy, Yangqing Lu, Guiping Zhao, Changbo Ou   +7 more
doaj   +1 more source

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

Extracellular vesicles secreted by cumulus cells contain microRNAs that are potential regulatory factors of mouse oocyte developmental competence [PDF]

: The role of cumulus cells (CCs) in the acquisition of oocyte developmental competence is not yet fully understood. In a previous study, we matured cumulus-denuded fully-grown mouse oocytes to metaphase II (MII) on a feeder layer of CCs (FL-CCs ...
Cereda, Cristina, Cimadomo, Danilo, Comincini, Sergio, Federica, Innocenti, Fiorentino, Giulia, Gagliardi, Stella, Garagna, Sylvia, Garofalo, Maria, Laura, Rienzi, Lin, Chih-Jen, Merico, Valeria, Sproviero, Daisy, Sproviero, Daisy, Taggi, Marilena, Ubaldi, Filippo, Vaiarelli, Alberto, Zanoni, Mario, Zuccotti, Maurizio   +17 more
core   +3 more sources

Functional Analysis of CCR4-NOT Complex in Pancreatic β Cell [PDF]

, 2020
Functional analysis of CCR4-NOT complex in pancreatic β cellPancreatic β cells are responsible for production and secretion of insulin in response to increasing blood glucose levels.
Dina Mostafa
core   +1 more source

Molecular and Physiological function of the mammalian CCR4-NOT subunit CNOT9 [PDF]

, 2020
Messenger RNA (mRNA) decay is an indisputable component of gene expression regulation. In higher eukaryotes such as humans and mice, this process is mainly governed by a multi-subunit protein assemblage known as the CCR4-NOT complex.
Hemanta Sarmah
core   +1 more source