Results 61 to 70 of about 86,048 (164)
Alzheimer’s Research & Therapy, 2018 Background Alzheimer’s disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the ...
D. M. Vargas +3 more
doaj +1 more source
Alzheimer's &Dementia, Volume 20, Issue 9, Page 6070-6081, September 2024.Abstract INTRODUCTION We conducted admixture mapping and fine‐mapping analyses to identify ancestry‐of‐origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years).
Rui Xia +20 more
wiley +1 more source
Аграрная наука Евро-Северо-ВостокаIn recent years, there has been a significant development of technologies in the field of genetics and breeding of cattle, which opens new opportunities for increasing productivity and quality of dairy products.
M. V. Levchenko +4 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated the role of CAF‐derived extracellular vesicle (EV)‐packaged long non‐coding RNAs (lncRNAs) in immune evasion ...
Hanming Yao +12 more
wiley +1 more source
mSphere, 2019 Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on ...
Ruwen Yang +9 more
doaj +1 more source
Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]
, 2013 MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core
Role of Cnot6l in maternal mRNA turnover. [PDF]
, 2018 Removal of poly(A) tail is an important mechanism controlling eukaryotic mRNA turnover. The major eukaryotic deadenylase complex CCR4-NOT contains two deadenylase components, CCR4 and CAF1, for which mammalian CCR4 is encoded by Cnot6 or Cnot6l paralogs.
Fulka, Helena +9 more
core +1 more source
Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy
Cancer Medicine, Volume 13, Issue 7, April 2024.The m6A methylation is catalysed by the writer complex and the demethylation is catalysed by the erasers. Different readers proteins determine the fate of m6A modification. These proteins have increasingly been recognised as targets for cancer therapy.
Angel Guan, Justin J.‐L. Wong
wiley +1 more source
Alzheimer's &Dementia, Volume 20, Issue 1, Page 652-694, January 2024.Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful ...
Dallas P. Veitch +22 more
wiley +1 more source
The central region of CNOT1 and CNOT9 stimulate deadenylation by the Ccr4 Not nuclease module [PDF]
, 2018 Regulated degradation of cytoplasmic mRNA is important for the accurate execution of gene expression programmes in eukaryotic cells. A key step in this process is the shortening and removal of the mRNA poly(A) tail, which can be achieved by the ...
Airhihen, Blessing +3 more
core +2 more sources