Results 61 to 70 of about 89,184 (144)
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma [PDF]
, 2020 © 2020 Informa UK Limited, trading as Taylor & Francis Group. Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement
Seedhouse, Claire +3 more
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Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes
Nature CommunicationsOocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu +11 more
doaj +1 more source
Poultry ScienceHeat stress and Salmonella infection are two major challenges threatening poultry health and productivity. Native breeds generally show stronger resistance than commercial lines, but the molecular mechanisms underlying this advantage remain unclear. This
Yaping Wang +7 more
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, 2016 The ectopically expressed CNOT7 migrates slightly higher than the endogenous band due to the addition of the FLAG epitope tag. The cell lines injected for 4T1 and Mvt1 experiments are indicated below the panels by arrows.
Farhoud Faraji (135917) +6 more
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Results of Cnot7 knockdown experiments for the cell lines 6DT1, Mvt1, and 4T1.
, 2016 Characterization of shRNA knockdowns at the protein (A-C) and mRNA (D-F) levels are shown across the top of the figure. The upper band in the western blots is a non-specific band that appears with some batches of α-CNOT7 antibody.
Farhoud Faraji (135917) +6 more
core +1 more source
, 2013 The sequences used for the alignment are: human Caf1a/CNOT7 (NP_037486), Xenopus laevis Caf1a/CNOT7 (NP_001089689), Danio rerio Caf1a/CNOT7 (NP_001070723), human Caf1b/hPop2/CNOT7 (NP_004770), Schizosaccharomyces pombe Caf1p/Pop2p (NP_588385), Capsicum ...
Yong-Bin Yan (295926) +2 more
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Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach [PDF]
Protein & Cell, 2015 Bai, Yuwei +8 more
openaire +2 more sources
A non-proteolytic role for ubiquitin in deadenylation by the RNA-binding E3 ligase MEX-3C [PDF]
, 2015 The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin—traditionally linked to protein degradation—directly regulates the degradation of mRNAs through the action of a newly identified ...
Rapiteanu, Radu +3 more
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Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1) [PDF]
Polyadenylation is the process of the addition of a poly(A) tail to the 3ʹ end of mRNA. The binding of human poly(A) binding protein to the poly(A) tail can either initiate or repress translation or regulate mRNA degradation. Cytoplasmic mRNA degradation
Ameerul Moominin, Aalam Mohammed
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Mtail-Seq For Pan2/3, Caf1A/B (Cnot7/8) Kd Hela Samples (Internal Id: Ms121)
, 2018 mTAIL-seq, MiSeq run (internal ID: ms121) spkN, spk8, spk16, spk32, spk64, spk118, spk128 spike-ins NC2 (siCont), 232 (siPAN2/3), 783 (siCAF1a/b or siCNOT7/8) samples This dataset contains cluster intensities of fluorescence signals that are repacked as an HDF5 formatted file.
Park, Joha, Yi, Hyerim, Kim, V. Narry
openaire +2 more sources