Results 61 to 70 of about 86,437 (152)

Extracellular vesicle‐packaged lncRNA from cancer‐associated fibroblasts promotes immune evasion by downregulating HLA‐A in pancreatic cancer

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated the role of CAF‐derived extracellular vesicle (EV)‐packaged long non‐coding RNAs (lncRNAs) in immune evasion ...
Hanming Yao, Chengzhi Huang, Jinmao Zou, Weiling Liang, Yue Zhao, Kege Yang, Ziyi Zhong, Shurui Zhou, Jiajia Li, Yaqing Li, Lishu Xu, Kaihong Huang, Guoda Lian   +12 more
wiley   +1 more source

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

Cancer Medicine, Volume 13, Issue 7, April 2024.
The m6A methylation is catalysed by the writer complex and the demethylation is catalysed by the erasers. Different readers proteins determine the fate of m6A modification. These proteins have increasingly been recognised as targets for cancer therapy.
Angel Guan, Justin J.‐L. Wong
wiley   +1 more source

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

Alzheimer's &Dementia, Volume 20, Issue 1, Page 652-694, January 2024.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful ...
Dallas P. Veitch, Michael W. Weiner, Melanie Miller, Paul S. Aisen, Miriam A. Ashford, Laurel A. Beckett, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, Susan M. Landau, John C. Morris, Kwangsik T. Nho, Rachel Nosheny, Ozioma Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

Expression levels of miR-466e-3p target genes. [PDF]

, 2014
Expression levels of Zfp704, Cnot7 and Cplx2, relative to control, were measured by quantitative real-time PCR. Results are the average of three independent experiments. Error bars represent standard deviation.
Hiroko Ishii-Ohba (623275), Guillaume Vares (471320), Tetsuo Nakajima (471322), Bing Wang (126120), Mitsuru Nenoi (471323)   +4 more
core   +1 more source

Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events

WIREs RNA, Volume 15, Issue 1, January/February 2024.
Not5 ribosome binding ensures co‐translational organellar targeting and protein assembly. Prolonged ribosome pausing leading to post‐translocation ribosomes with empty A and E sites allows Not5 ribosome binding. This Not5 ribosome binding is key for co‐translational events such as organellar targeting or assembly of proteins.
Martine A. Collart, Léna Audebert, Martin Bushell   +2 more
wiley   +1 more source

Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker [PDF]

, 2012
Background/Aims: The degradation of mRNA is a key process in the control of gene expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA degradation is the removal of the poly(A) tail by deadenylases.
Karangeli, M., Papaspyrou, K., Labrou, M., Pournaras, S., Dimoulou, G., Matsouka, P., Gourgoulianis, K. I., Salataj, E., Balatsos, N. A. A., Maragozidis, P.   +9 more
core   +1 more source

A comparison of the crystal structure of S. pombe Caf1p/Pop2p (gray, PDB ID: 2P51) and the predicted structure of CrCaf1 (red). [PDF]

, 2013
The homology modeling of CrCaf1 structure was performed by SWISS-MODEL using the crystal structure of human Caf1a/CNOT7 (PDB ID: 2D5R) as the template structure. N and C are the N- and C-termini of the proteins.
Yong-Bin Yan (295926), Jia-Quan Zhang (435852), Guang-Jun He (329060)   +2 more
core   +1 more source

A non-proteolytic role for ubiquitin in deadenylation by the RNA-binding E3 ligase MEX-3C [PDF]

, 2015
The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin—traditionally linked to protein degradation—directly regulates the degradation of mRNAs through the action of a newly identified ...
Rapiteanu, Radu, Winkler, G.S., Lehner, Paul J., Cano, Florencia   +3 more
core   +2 more sources

Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes

Nature Communications
Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu, Wenrong Tao, Shuang Wu, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang, Falong Lu, Keliang Wu   +11 more
doaj   +1 more source

Daisy Chain Topology Based Mammalian Synthetic Circuits for RNA-Only Delivery [PDF]

, 2020
Owing to superior safety, the RNA-only delivery synthetic circuit is more suitable for cell-based medicine. Modules which possess matching inputs and outputs could be strung by daisy-chaining to compose RNA-only delivery synthetic gene circuits.
Kaiyu Liu (309766), Shigang Ding (8275170), Jiong Yang (82529), Yi Gao (112914)   +3 more
core   +1 more source