Results 41 to 50 of about 89,184 (144)
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +1 more source
Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes
Cellular Physiology and Biochemistry, 2018 Background/Aims: Spaceflight negatively influences the function of cartilage tissue in vivo. In vitro human chondrocytes exhibit an altered gene expression of inflammation markers after a two-hour exposure to vibration.
Ronald Lützenberg +14 more
doaj +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]
The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types.
Doidge, Rachel L.
core +3 more sources
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Advanced Science, Volume 12, Issue 39, October 20, 2025.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source
European Journal of Neuroscience, Volume 61, Issue 10, May 2025.This study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Fiona Qiu +4 more
wiley +1 more source
Alzheimer’s Research & Therapy, 2018 Background Alzheimer’s disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the ...
D. M. Vargas +3 more
doaj +1 more source
Cell Proliferation, Volume 58, Issue 3, March 2025.Construct postovulatory ageing protein map to deeply analyse the dynamic changes of postovulatory ageing proteins. DCP1A accumulation accelerates maternal mRNA decay in postovulatory‐aged oocytes. SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes.
Li Kong +10 more
wiley +1 more source
Аграрная наука Евро-Северо-ВостокаIn recent years, there has been a significant development of technologies in the field of genetics and breeding of cattle, which opens new opportunities for increasing productivity and quality of dairy products.
M. V. Levchenko +4 more
doaj +1 more source