eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR [PDF]
, 2019 Background: Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understood.
Bushell, Martin +14 more
core +3 more sources
Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice
Archives of Histology and Cytology, 2004 Cnot7 is a co-factor of transcription regulation, expressed in a variety of tissues including the lung, liver, thyroid gland, and testis. Our previous study (Nakamura et al., 2004) showed that deletion of the Cnot7 gene in mice caused almost no abnormal phenotypes except for male infertility, due to oligo-astheno-teratozoospermia.
Takehiko, Ogawa +7 more
openaire +3 more sources
Poly(A) Tail Regulation in the Nucleus [PDF]
, 2022 Der Ribonukleinsäure (RNS) Stoffwechsel umfasst verschiedene Schritte, beginnend mit der Transkription der RNS über die Translation bis zum RNA Abbau.
Alles, Jonathan
core +1 more source
Posterior Contraction Rates of the Phylogenetic Indian Buffet Processes [PDF]
, 2015 By expressing prior distributions as general stochastic processes, nonparametric Bayesian methods provide a flexible way to incorporate prior knowledge and constrain the latent structure in statistical inference.
Chen, Mengjie, Gao, Chao, Zhao, Hongyu
core +3 more sources
The DDX6-4E-T interaction mediates translational repression and P-body assembly [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P ...
Broomhead, H +9 more
core +1 more source
The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions [PDF]
, 2022 The evolutionary conserved CCR4-NOT complex functions in the cytoplasm as the main mRNA deadenylase in both constitutive mRNA turnover and regulated mRNA decay pathways.
Albrecht, J. +7 more
core +3 more sources
A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells. [PDF]
, 2019 Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes.
Carrano, Andrea C +15 more
core +2 more sources
CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner [PDF]
, 2022 Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Adachi Shungo +6 more
core +1 more source
Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus [PDF]
, 2016 Much adaptive evolutionary change is underlain by mutational variation in regions of the genome that regulate gene expression rather than in the coding regions of the genes themselves.
Leder, Erica H. +6 more
core +4 more sources
Advanced Science, Volume 12, Issue 39, October 20, 2025.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source