Results 41 to 50 of about 86,437 (152)
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Genetic oscillators play crucial roles in development. The hairy/Enhancer of split gene family (Hes/her) undergo cell‐autonomous genetic oscillations to regulate the timing of vertebrate segmentation and neural cell proliferation and differentiation. mRNA stability and translation are tightly regulated to maintain oscillatory expression.
Monica C. Blatnik +2 more
wiley +1 more source
Co-immunoprecipitation of the Cnot7 mutants confirming the specific disruption of interaction with TOB1 by the E247A/Y260A mutant (A). [PDF]
, 2016 Co-immunoprecipitation of the Cnot7 mutants confirming the specific disruption of interaction with CNOT1 by the M141R mutant (B). Western blot confirming the equal expression of Cnot7 constructs in cells used for spontaneous metastasis assays (C).
Farhoud Faraji (135917) +6 more
core +1 more source
Western blots showing the relative expression of exogenously expressed CNOT7 and the D40A mutant in 6DT1 (A), 4T1 (B) and Mvt1 (C). [PDF]
, 2016 The ectopically expressed CNOT7 migrates slightly higher than the endogenous band due to the addition of the FLAG epitope tag. The cell lines injected for 4T1 and Mvt1 experiments are indicated below the panels by arrows.
Farhoud Faraji (135917) +6 more
core +1 more source
CHARACTERIZING RNA-PROTEIN INTERACTIONS AND DEFINING PROXIMITY-MEDIATED FUNCTION OF RNA REGULATORY PROTEINS [PDF]
, 2023 Extensive, dynamic RNA-protein interactions occur during the lifecycle of most RNAs. Some RNA- protein interactions are the drivers of disease, while others are critical for cell homeostasis.
Hatfield, Breanne Marie
core +2 more sources
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +1 more source
Advanced Science, Volume 12, Issue 39, October 20, 2025.During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang +8 more
wiley +1 more source
Results of Cnot7 knockdown experiments for the cell lines 6DT1, Mvt1, and 4T1. [PDF]
, 2016 Characterization of shRNA knockdowns at the protein (A-C) and mRNA (D-F) levels are shown across the top of the figure. The upper band in the western blots is a non-specific band that appears with some batches of α-CNOT7 antibody.
Farhoud Faraji (135917) +6 more
core +1 more source
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma [PDF]
, 2020 © 2020 Informa UK Limited, trading as Taylor & Francis Group. Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10–15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement
Seedhouse, Claire +3 more
core +2 more sources
Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes
Cellular Physiology and Biochemistry, 2018 Background/Aims: Spaceflight negatively influences the function of cartilage tissue in vivo. In vitro human chondrocytes exhibit an altered gene expression of inflammation markers after a two-hour exposure to vibration.
Ronald Lützenberg +14 more
doaj +1 more source
European Journal of Neuroscience, Volume 61, Issue 10, May 2025.This study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Fiona Qiu +4 more
wiley +1 more source