Results 21 to 30 of about 86,437 (152)
Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach [PDF]
Protein & Cell, 2015 Bai, Yuwei +8 more
openaire +4 more sources
Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
doaj +1 more source
Identification of Key Circulating Exosomal microRNAs in Gastric Cancer
Frontiers in Oncology, 2021 Exosomal miRNAs (EmiRs) can be used for prediction of gastric cancer (GC) development. Supposedly, both plasma and urinary microRNAs can also be potential biomarkers for screening, but the diagnostic values of EmiRs in blood and urine are not fully ...
Xiaoqing Qian +4 more
doaj +1 more source
LBs are enriched with DDX6 and CNOT7 proteins. [PDF]
, 2023 (A) Double immunofluorescence staining of RNA helicase DDX6 (green) and L1 ORF1p (magenta) in Mael+/- and Mael-/- testes. DDX6 is detectable in cytoplasmic foci in both Mael+/- and Mael-/- spermatogonia and spermatocytes (yellow arrows); in Mael-/- both ...
Chiara De Luca (139084) +2 more
core +1 more source
Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas
Molecules, 2022 The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression.
Athanasios Kyritsis +11 more
doaj +1 more source
Cell Reports, 2021 Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this
Xing-Xing Dai +8 more
doaj +1 more source
Acta Neuropathologica Communications, 2021 Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer’s disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to
Vijay K. Ramanan +13 more
doaj +1 more source
Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal
Genes to Cells, 2017 mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. During maternal‐to‐zygotic transition of animal development, thousands of maternal mRNAs are degraded by multiple mechanisms including microRNAs and codon‐mediated decay. Enzymatic requirements for maternal mRNA clearance, however, are not fully
Yuichiro Mishima, Yukihide Tomari
openaire +2 more sources
Cells, 2023 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim +6 more
doaj +1 more source
Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023 The study analyzes transcriptomes, translatomes, and proteomes of mouse and human GV oocytes at the single‐cell level with a focus on conservations and differences in maternal aging between the two species. N6‐methyladenosine (m6A) reader YTHDF3 and alternative splicing factor SRSF6 are associated with the aging‐associated translational control in ...
Jiana Huang +13 more
wiley +1 more source