Results 21 to 30 of about 89,184 (144)
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]
, 2013 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases.
Doidge, Rachel L, Doidge, Rachel L.
openaire +3 more sources
Structural model of the human BTG2-PABPC1 complex by combining mutagenesis, NMR chemical shift perturbation data and molecular docking. [PDF]
, 2022 Degradation of cytoplasmic mRNA in eukaryotes involves the shortening and removal of the mRNA poly(A) tail by poly(A)-selective ribonuclease (deadenylase) enzymes.
Gerlof Sebastiaan Winkler (12967262) +4 more
core +8 more sources
Identification of Key Circulating Exosomal microRNAs in Gastric Cancer
Frontiers in Oncology, 2021 Exosomal miRNAs (EmiRs) can be used for prediction of gastric cancer (GC) development. Supposedly, both plasma and urinary microRNAs can also be potential biomarkers for screening, but the diagnostic values of EmiRs in blood and urine are not fully ...
Xiaoqing Qian +4 more
doaj +1 more source
Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas
Molecules, 2022 The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression.
Athanasios Kyritsis +11 more
doaj +1 more source
Cell Reports, 2021 Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this
Xing-Xing Dai +8 more
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Acta Neuropathologica Communications, 2021 Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer’s disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to
Vijay K. Ramanan +13 more
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Cells, 2023 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim +6 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency.
Cheuk Yin Li +8 more
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Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023 The study analyzes transcriptomes, translatomes, and proteomes of mouse and human GV oocytes at the single‐cell level with a focus on conservations and differences in maternal aging between the two species. N6‐methyladenosine (m6A) reader YTHDF3 and alternative splicing factor SRSF6 are associated with the aging‐associated translational control in ...
Jiana Huang +13 more
wiley +1 more source
Silencing of CCR4-NOT complex subunits affects heart structure and function
Disease Models & Mechanisms, 2020 The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous.
Lisa Elmén +13 more
doaj +1 more source