CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential [PDF]
International Journal of Molecular SciencesMetastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progression and natural killer (NK) cell resistance. In the current study, 90 female BC patients (46 non-metastatic, 44
Dina Mostafa +2 more
exaly +7 more sources
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. [PDF]
PLoS ONE, 2012 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge +3 more
doaj +4 more sources
Alternative splicing of CNOT7 diversifies CCR4–NOT functions [PDF]
Nucleic Acids Research, 2017 The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm. In human cells, alternative splicing of the CNOT7 gene yields a second CNOT7 transcript leading to the formation of a ...
Chapat, Clément +6 more
openaire +6 more sources
Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7 [PDF]
, 2017 Local translation of mRNAs in dendrites is vital for synaptic plasticity and learning and memory. Tight regulation of this translation is key to preventing neurological disorders resulting from aberrant local translation. Here we find that CNOT7, the major deadenylase in eukaryotic cells, takes on the distinct role of regulating local translation in ...
McFleder, Rhonda L.
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Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity [PDF]
Cell Reports, 2015 Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally.
Akinori Takahashi +6 more
doaj +2 more sources
Aging Cell, Volume 22, Issue 4, April 2023., 2023 This study reveals a new role for the CCR4‐NOT complex in transcriptome regulation in response to environmental stress using the C. elegans model. CCF‐1/CNOT7 encoding the deadenylase subunit of the complex is required for activation of xenobiotic detoxification genes in response to stress, which in turn is critical for enhancing whole‐organism stress ...
Hadi Tabarraei +6 more
wiley +3 more sources
Investigation of the PABPC1-BTG2 interaction and its effects on mRNA deadenylation by CNOT7(CAF1) [PDF]
, 2022 Polyadenylation is the process of the addition of a poly(A) tail to the 3ʹ end of mRNA. The binding of human poly(A) binding protein to the poly(A) tail can either initiate or repress translation or regulate mRNA degradation. Cytoplasmic mRNA degradation in eukaryotes involves shortening of mRNA poly(A) tail by poly(A)-selective ribonuclease ...
Ameerul Moominin, Aalam Mohammed
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CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex [PDF]
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT ComplexThe CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1. They are highly similar and are sometimes considered redundant, but Cnot7 and Cnot8 knockout mice exhibit different phenotypes, implying distinct ...
Nishijima, Saori +3 more
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Μελέτες στη βιολογική σημασία της ανθρώπινης αποαδενυλάσης CNOT7 [PDF]
, 2010 Η ακριβής γονιδιακή έκφραση απαιτεί συνεχή έλεγχο των επιπέδων του mRNA. Η αποικοδόμηση του mRNA αποτελεί ρυθμιστικό στοιχείο της γονίδιακής έκφρασης. Στα κύτταρα των θηλαστικών το κύριο μονοπάτι αποικοδόμησης ξεκινά με αποαδενυλίωση, την αφαίρεση δηλαδή των πολύ(Α) ουρών από το 3' άκρο ενός ώριμου mRNA.
Παλλάκη, Πασχαλίνα
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The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes [PDF]
, 2013 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases.
Doidge, Rachel L, Doidge, Rachel L.
openaire +4 more sources