Results 11 to 20 of about 86,048 (164)
Aging Cell, Volume 22, Issue 4, April 2023., 2023 This study reveals a new role for the CCR4‐NOT complex in transcriptome regulation in response to environmental stress using the C. elegans model. CCF‐1/CNOT7 encoding the deadenylase subunit of the complex is required for activation of xenobiotic detoxification genes in response to stress, which in turn is critical for enhancing whole‐organism stress ...
Hadi Tabarraei +6 more
wiley +3 more sources
PLoS ONE, 2012 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge +3 more
doaj +3 more sources
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]
FEBS Open BioWe identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Soeda S +9 more
europepmc +2 more sources
Sumoylation of eIF4A2 affects stress granule formation [PDF]
, 2016 Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis.
Anderson +52 more
core +14 more sources
Alternative splicing of CNOT7 diversifies CCR4–NOT functions [PDF]
Nucleic Acids Research, 2017 The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm. In human cells, alternative splicing of the CNOT7 gene yields a second CNOT7 transcript leading to the formation of a ...
Chapat, Clément +6 more
openaire +4 more sources
Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
doaj +1 more source
Identification of Key Circulating Exosomal microRNAs in Gastric Cancer
Frontiers in Oncology, 2021 Exosomal miRNAs (EmiRs) can be used for prediction of gastric cancer (GC) development. Supposedly, both plasma and urinary microRNAs can also be potential biomarkers for screening, but the diagnostic values of EmiRs in blood and urine are not fully ...
Xiaoqing Qian +4 more
doaj +1 more source
Distinct genes related to drug response identified in ER positive and ER negative breast cancer cell lines [PDF]
, 2012 Breast cancer patients have different responses to chemotherapeutic treatments. Genes associated with drug response can provide insight to understand the mechanisms of drug resistance, identify promising therapeutic opportunities, and facilitate ...
A Hershko +50 more
core +9 more sources
Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas
Molecules, 2022 The poly(A) tail at the 3′ end of mRNAs determines their stability, translational efficiency, and fate. The shortening of the poly(A) tail, and its efficient removal, triggers the degradation of mRNAs, thus, regulating gene expression.
Athanasios Kyritsis +11 more
doaj +1 more source
Cell Reports, 2021 Summary: CCR4-NOT deadenylase is a major regulator of mRNA turnover. It contains two heterogeneous catalytic subunits CNOT7/8 and CNOT6/6L in vertebrates. The physiological function of each catalytic subunit is unclear due to the gene redundancy. In this
Xing-Xing Dai +8 more
doaj +1 more source