Results 1 to 10 of about 89,003 (108)
Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]
BiomoleculesThe human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Sebastiaan Winkler +2 more
exaly +4 more sources
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair [PDF]
Cell Death and DiseaseRadiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li +11 more
doaj +2 more sources
Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study. [PDF]
Pain Res ManagPurpose To investigate the association between purine metabolism–related genes and trigeminal neuralgia (TN) using multiomics approaches. Methods A multiomics summary‐data‐based Mendelian randomization (SMR) approach was applied to investigate associations between purine metabolism–related genes and TN.
Shen S +9 more
europepmc +2 more sources
FEBS Open Bio, 2020 A major obstacle to effective cancer immunotherapy is the tumor immune microenvironment. Natural killer (NK) cell resistance has been suggested as a primary cause of poor prognosis in hepatocellular carcinoma (HCC), which seemingly correlates with CNOT7 ...
Chongren Ren, Xiaojing Ren, Xifeng Fu
exaly +2 more sources
Cell Reports, 2017 Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda McFleder +2 more
exaly +3 more sources
MicroRNA-126-5p Inhibits the Migration of Breast Cancer Cells by Directly Targeting CNOT7
Technology in Cancer Research and Treatment, 2020 Background: To assess the effect of microRNA-126-5p (miR-126-5p) on the migration of the breast cancer MCF7 cell line. Methods: GSE143564 was downloaded from the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo ) to identify the ...
Lecan Sun
exaly +2 more sources
PLoS Genetics, 2016 Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji +2 more
exaly +2 more sources
MoleculesThe Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Sebastiaan Winkler +2 more
exaly +3 more sources
CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential [PDF]
International Journal of Molecular SciencesTadashi Yamamoto +2 more
exaly +2 more sources
Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
doaj +1 more source