Results 1 to 10 of about 86,295 (107)
Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]
BiomoleculesThe human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur +3 more
doaj +2 more sources
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair [PDF]
Cell Death and DiseaseRadiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li +11 more
doaj +2 more sources
FEBS Open Bio, 2020 A major obstacle to effective cancer immunotherapy is the tumor immune microenvironment. Natural killer (NK) cell resistance has been suggested as a primary cause of poor prognosis in hepatocellular carcinoma (HCC), which seemingly correlates with CNOT7 ...
Xiaojing Ren +2 more
exaly +2 more sources
Cell Reports, 2017 Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L Mcfleder +2 more
exaly +3 more sources
MicroRNA-126-5p Inhibits the Migration of Breast Cancer Cells by Directly Targeting CNOT7
Technology in Cancer Research and Treatment, 2020 Background: To assess the effect of microRNA-126-5p (miR-126-5p) on the migration of the breast cancer MCF7 cell line. Methods: GSE143564 was downloaded from the Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo ) to identify the ...
Lecan Sun
exaly +2 more sources
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity. [PDF]
FEBS Open BioWe identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Soeda S +9 more
europepmc +2 more sources
The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT [PDF]
mSphereThe eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen.
Harley O'Connor Mount +4 more
doaj +2 more sources
RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4-NOT and Promote Cell Proliferation. [PDF]
Cell ProlifMutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen C, Guo C, Fang K, Lin C, Luo Z.
europepmc +2 more sources
PLoS Genetics, 2016 Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji +2 more
exaly +2 more sources
MoleculesThe Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur +2 more
exaly +3 more sources