A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. [PDF]
, 2015 The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified ...
Cano, Florencia +3 more
core +3 more sources
Development of 14‐gene signature prognostic model based on metastasis for colorectal cancer
Journal of Clinical Laboratory Analysis, Volume 37, Issue 1, January 2023., 2023 A 14‐gene signature prognostic model was constructed by analyzing genes specifically expressed in metastatic colorectal tumors. This model can be used to predict the survival rates of CRC patients. We also preliminarily examined the immunology‐based mechanisms controlling colorectal tumor metastasis.
Tong Li +11 more
wiley +1 more source
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Genetic oscillators play crucial roles in development. The hairy/Enhancer of split gene family (Hes/her) undergo cell‐autonomous genetic oscillations to regulate the timing of vertebrate segmentation and neural cell proliferation and differentiation. mRNA stability and translation are tightly regulated to maintain oscillatory expression.
Monica C. Blatnik +2 more
wiley +1 more source
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]
, 2005 We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer +24 more
core +2 more sources
Chemistry – A European Journal, Volume 28, Issue 42, July 26, 2022., 2022 Oligonucleotide mRNA poly(A) tail analogs containing various nucleotide modifications were evaluated as binders for poly(A) binding protein (PABP) using a microscale thermophoresis‐based assay. Their susceptibility to specific degradation by CNOT7 deadenylase was also examined in order to identify best stabilizing modifications.
Olga Perzanowska +3 more
wiley +1 more source
Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity
Cell Reports, 2015 Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally.
Akinori Takahashi +6 more
doaj +1 more source
Acute mammary and liver transcriptome responses after an intramammary Escherichia coli lipopolysaccharide challenge in postpartal dairy cows [PDF]
, 2015 The study investigated the effect of an intramammary lipopolysaccharide (LPS) challenge on the bovine mammary and liver transcriptome and its consequences on metabolic biomarkers and liver tissue composition.
Cardoso, Felipe C. +7 more
core +1 more source
Apolipoprotein E genotype status affects habitual human blood mononuclear cell gene expression and its response to fish oil intervention [PDF]
, 2016 SCOPE: People who carry the apolipoprotein E4 (APOE4) SNP have an increased risk of cardiovascular disease (CVD). Fish-oil supplementation may help in the prevention of CVD, though inter-individual differences in the response to n-3 PUFAs have been ...
Baitsch +36 more
core +2 more sources
Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal
Genes to Cells, 2017 mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. During maternal‐to‐zygotic transition of animal development, thousands of maternal mRNAs are degraded by multiple mechanisms including microRNAs and codon‐mediated decay. Enzymatic requirements for maternal mRNA clearance, however, are not fully
Yuichiro Mishima, Yukihide Tomari
openaire +2 more sources
Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance [PDF]
, 2018 Ovarian cancer has the highest mortality rate among all the gynecological cancers. This is mostly due to the resistance of ovarian cancer to current chemotherapy regimens.
Benito i Mundet, Antoni +4 more
core +2 more sources