Results 31 to 40 of about 86,437 (152)
Molecular Therapy: Nucleic Acids, 2022 Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins. However, the practical use of synthetic mRNAs has been restricted by their low cellular stability as well as poor protein production efficiency.
Cheuk Yin Li +8 more
doaj +1 more source
Epigenetic reprogramming during the maternal‐to‐zygotic transition
MedComm, Volume 4, Issue 4, August 2023., 2023 Graphical Abstract: The DNA methylation, histone modification, chromatin structure, and RNA modification are important epigenetic modifications that are reprogrammed during the maternal‐to‐zygote transition (MZT). Their reprogramming processes are regulated by multiple underlying molecular mechanisms that were discussed in the paper.
Yurong Chen +4 more
wiley +1 more source
Structural Model of the Human BTG2–PABPC1 Complex by Combining Mutagenesis, NMR Chemical Shift Perturbation Data and Molecular Docking [PDF]
, 2022 Degradation of cytoplasmic mRNA in eukaryotes involves the shortening and removal of the mRNA poly(A) tail by poly(A)-selective ribonuclease (deadenylase) enzymes.
Gerlof Sebastiaan Winkler (12967262) +9 more
core +4 more sources
Silencing of CCR4-NOT complex subunits affects heart structure and function
Disease Models & Mechanisms, 2020 The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous.
Lisa Elmén +13 more
doaj +1 more source
Open Biology, 2023 Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan +4 more
doaj +1 more source
APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage
The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023 A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich +11 more
wiley +1 more source
Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells
Molecular Therapy: Nucleic Acids, 2021 Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis ...
Jiong Yang, Shigang Ding
doaj +1 more source
Clinical Genetics, Volume 103, Issue 2, Page 156-166, February 2023., 2023 Abstract CNOT2 haploinsufficiency underlies a rare neurodevelopmental disorder named Intellectual Developmental disorder with NAsal speech, Dysmorphic Facies, and variable Skeletal anomalies (IDNADFS, OMIM 618608). The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to ...
Marcello Niceta +21 more
wiley +1 more source
Development of 14‐gene signature prognostic model based on metastasis for colorectal cancer
Journal of Clinical Laboratory Analysis, Volume 37, Issue 1, January 2023., 2023 A 14‐gene signature prognostic model was constructed by analyzing genes specifically expressed in metastatic colorectal tumors. This model can be used to predict the survival rates of CRC patients. We also preliminarily examined the immunology‐based mechanisms controlling colorectal tumor metastasis.
Tong Li +11 more
wiley +1 more source
(A) Design of the MMTV-PyMT x Cnot7 knockout mouse cross experiment. [PDF]
, 2016 (B) Relative expression of Cnot7 mRNA in the spleens of control and heterozygous knockout animals. (C) Relative expression of Cnot7 mRNA in bulk primary tumors of control and heterozygous knockout animals.
Farhoud Faraji (135917) +6 more
core +1 more source