Results 31 to 40 of about 89,184 (144)

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts

Open Biology, 2023
Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan, Pelagia Koukouraki, Athanasios K. Anagnostopoulos, George T. Tsangaris, Epaminondas Doxakis   +4 more
doaj   +1 more source

Epigenetic reprogramming during the maternal‐to‐zygotic transition

MedComm, Volume 4, Issue 4, August 2023., 2023
Graphical Abstract: The DNA methylation, histone modification, chromatin structure, and RNA modification are important epigenetic modifications that are reprogrammed during the maternal‐to‐zygote transition (MZT). Their reprogramming processes are regulated by multiple underlying molecular mechanisms that were discussed in the paper.
Yurong Chen, Luyao Wang, Fucheng Guo, Xiangpeng Dai, Xiaoling Zhang   +4 more
wiley   +1 more source

Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells

Molecular Therapy: Nucleic Acids, 2021
Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis ...
Jiong Yang, Shigang Ding
doaj   +1 more source

APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage

The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023
A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich, Jing Ma, Eran Kotler, Faizan Hassan, Alexander Botvinnik, Yoav Smith, Ofra Moshel, Abed Nasereddin, Gunjan Sharma, Eli Pikarsky, Susan Ross, Moshe Kotler   +11 more
wiley   +1 more source

Delineation of the clinical profile of CNOT2 haploinsufficiency and overview of the IDNADFS phenotype

Clinical Genetics, Volume 103, Issue 2, Page 156-166, February 2023., 2023
Abstract CNOT2 haploinsufficiency underlies a rare neurodevelopmental disorder named Intellectual Developmental disorder with NAsal speech, Dysmorphic Facies, and variable Skeletal anomalies (IDNADFS, OMIM 618608). The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to ...
Marcello Niceta, Simone Pizzi, Francesca Inzana, Angela Peron, Somayeh Bakhtiari, Mathilde Nizon, Jonathan Levy, Cecilia Mancini, Benjamin Cogné, Francesca Clementina Radio, Emanuele Agolini, Dario Cocciadiferro, Antonio Novelli, Mustafa A. Salih, Maria Paola Recalcati, Rosangela Arancio, Marianne Besnard, Anne‐Claude Tabet, Michael C. Kruer, Manuela Priolo, Bruno Dallapiccola, Marco Tartaglia   +21 more
wiley   +1 more source

Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish [PDF]

Genes to Cells, 2017
mRNA degradation is a fundamental biological process that erases transcribed genetic information from cells. During maternal‐to‐zygotic transition of animal development, thousands of maternal mRNAs are degraded by multiple mechanisms including microRNAs and codon‐mediated decay. Enzymatic requirements for maternal mRNA clearance, however, are not fully
Yuichiro Mishima, Yukihide Tomari
openaire   +2 more sources

LBs are enriched with DDX6 and CNOT7 proteins.

, 2023
(A) Double immunofluorescence staining of RNA helicase DDX6 (green) and L1 ORF1p (magenta) in Mael+/- and Mael-/- testes. DDX6 is detectable in cytoplasmic foci in both Mael+/- and Mael-/- spermatogonia and spermatocytes (yellow arrows); in Mael-/- both ...
Chiara De Luca (139084), Anuj Gupta (4328764), Alex Bortvin (256348)   +2 more
core   +1 more source

(A) Design of the MMTV-PyMT x Cnot7 knockout mouse cross experiment.

, 2016
(B) Relative expression of Cnot7 mRNA in the spleens of control and heterozygous knockout animals. (C) Relative expression of Cnot7 mRNA in bulk primary tumors of control and heterozygous knockout animals.
Farhoud Faraji (135917), Howard H. Yang (252751), G. Sebastian Winkler (847958), Ying Hu (14950), Markus Hafner (186692), Kent W. Hunter (135937), Maxwell P. Lee (31055)   +6 more
core   +1 more source

Early brain‐penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1‐related Aicardi‐Goutières syndrome

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
Abstract Objectives Aicardi‐Goutières syndrome (AGS) is a genetic interferonopathy resulting from defects in nucleic acid metabolism and subsequent enhanced type I interferon signalling. We report how an expedited genomic diagnosis in conjunction with natural history data can enable a long‐term brain‐penetrant anti‐inflammatory regimen to optimise ...
Russell C Dale, Jessica Hayes, Velda X Han, Ruwani Dissanayake, Xianzhong Lau, Michelle Farrar, Brian Gloss, Markus Hofer, Esther Tantsis, Michelle Lorentzos, Safiyyah Abbas, Yanick J Crow, Shekeeb Mohammad, Shrujna Patel   +13 more
wiley   +1 more source

RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4‐NOT and Promote Cell Proliferation

Cell Proliferation, Volume 59, Issue 1, January 2026.
Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen, Chenghao Guo, Ke Fang, Chengqi Lin, Zhuojuan Luo   +4 more
wiley   +1 more source