Results 51 to 60 of about 86,437 (152)

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source

Multi‐omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes

Cell Proliferation, Volume 58, Issue 3, March 2025.
Construct postovulatory ageing protein map to deeply analyse the dynamic changes of postovulatory ageing proteins. DCP1A accumulation accelerates maternal mRNA decay in postovulatory‐aged oocytes. SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes.
Li Kong, Yutian Gong, Yongyong Wang, Mengjiao Yuan, Wenxiang Liu, Heyang Zhou, Xiangyue Meng, Xinru Guo, Yongbin Liu, Yang Zhou, Teng Zhang   +10 more
wiley   +1 more source

Sequence alignment of Caf1s. [PDF]

, 2013
The sequences used for the alignment are: human Caf1a/CNOT7 (NP_037486), Xenopus laevis Caf1a/CNOT7 (NP_001089689), Danio rerio Caf1a/CNOT7 (NP_001070723), human Caf1b/hPop2/CNOT7 (NP_004770), Schizosaccharomyces pombe Caf1p/Pop2p (NP_588385), Capsicum ...
Yong-Bin Yan (295926), Jia-Quan Zhang (435852), Guang-Jun He (329060)   +2 more
core   +1 more source

Μελέτη της έκφρασης της αποαδενυλάσης CNOT7 σε ασθενείς με λευχαιμία [PDF]

, 2011
Δημουλού, Γεωργία Σ.
openaire   +2 more sources

Methyltransferase‐Like 3‐Mediated N6‐Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats.
Dongqiong Xiao, Deshuang Zhang, Yi Qu, Xiaojuan Su   +3 more
wiley   +1 more source

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

Alzheimer’s Research & Therapy, 2018
Background Alzheimer’s disease (AD) is a multifactorial and complex neuropathology that involves impairment of many intricate molecular mechanisms. Despite recent advances, AD pathophysiological characterization remains incomplete, which hampers the ...
D. M. Vargas, M. A. De Bastiani, E. R. Zimmer, F. Klamt   +3 more
doaj   +1 more source

Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug‐Based In Situ Tissue Engineering

Stem Cells International, Volume 2025, Issue 1, 2025.
Background Mesenchymal stromal cells (MSCs) support tissue repair in osteoarthritis (OA), with migration to damaged tissue being a key strategy in in situ tissue engineering. Their regenerative potential depends on factors such as differentiation, level of senescence, and responsiveness to signaling molecules.
Julia Sonnleitner, Katja Gulich, Axel Pruss, Carsten Perka, Angelika Gursche, Daniel Kendoff, Michael Sittinger, Shabnam Hemmati-Sadeghi, Tilo Dehne, Yuriy Petrenko   +9 more
wiley   +1 more source

Identification of genes associated with technological properties of cow milk using GWA analysis and gene ontology

Аграрная наука Евро-Северо-Востока
In recent years, there has been a significant development of technologies in the field of genetics and breeding of cattle, which opens new opportunities for increasing productivity and quality of dairy products.
M. V. Levchenko, G. G. Karlikova, G. K. Petryakova, I. A. Lashneva, A. A. Sermyagin   +4 more
doaj   +1 more source

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos

Alzheimer's &Dementia, Volume 20, Issue 9, Page 6070-6081, September 2024.
Abstract INTRODUCTION We conducted admixture mapping and fine‐mapping analyses to identify ancestry‐of‐origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years).
Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles DeCarli, Linda C. Gallo, David C. Glahn, Emma E. M. Knowles, Jee‐Young Moon, Thomas H. Mosley, Claudia L. Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M. González, Myriam Fornage   +20 more
wiley   +1 more source

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis

mSphere, 2019
Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on ...
Ruwen Yang, Jana Klimentová, Elke Göckel-Krzikalla, Regina Ly, Nadine Gmelin, Agnes Hotz-Wagenblatt, Helena Řehulková, Jiří Stulík, Frank Rösl, Martina Niebler   +9 more
doaj   +1 more source