Results 51 to 60 of about 89,184 (144)

Methyltransferase‐Like 3‐Mediated N6‐Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats.
Dongqiong Xiao, Deshuang Zhang, Yi Qu, Xiaojuan Su   +3 more
wiley   +1 more source

Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis

mSphere, 2019
Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on ...
Ruwen Yang, Jana Klimentová, Elke Göckel-Krzikalla, Regina Ly, Nadine Gmelin, Agnes Hotz-Wagenblatt, Helena Řehulková, Jiří Stulík, Frank Rösl, Martina Niebler   +9 more
doaj   +1 more source

Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug‐Based In Situ Tissue Engineering

Stem Cells International, Volume 2025, Issue 1, 2025.
Background Mesenchymal stromal cells (MSCs) support tissue repair in osteoarthritis (OA), with migration to damaged tissue being a key strategy in in situ tissue engineering. Their regenerative potential depends on factors such as differentiation, level of senescence, and responsiveness to signaling molecules.
Julia Sonnleitner, Katja Gulich, Axel Pruss, Carsten Perka, Angelika Gursche, Daniel Kendoff, Michael Sittinger, Shabnam Hemmati-Sadeghi, Tilo Dehne, Yuriy Petrenko   +9 more
wiley   +1 more source

Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation1

Biology of Reproduction, 2015
Maternal mRNAs in oocytes are remarkably stable. In mouse, oocyte maturation triggers a transition from mRNA stability to instability. This transition is a critical event in the oocyte-to-embryo transition in which a differentiated oocyte loses its identity as it is transformed into totipotent blastomeres.
Jun, Ma, Yusuke, Fukuda, Richard M, Schultz   +2 more
openaire   +2 more sources

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos

Alzheimer's &Dementia, Volume 20, Issue 9, Page 6070-6081, September 2024.
Abstract INTRODUCTION We conducted admixture mapping and fine‐mapping analyses to identify ancestry‐of‐origin loci influencing cognitive abilities. METHODS We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years).
Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles DeCarli, Linda C. Gallo, David C. Glahn, Emma E. M. Knowles, Jee‐Young Moon, Thomas H. Mosley, Claudia L. Satizabal, Tamar Sofer, Wassim Tarraf, Fernando Testai, John Blangero, Sudha Seshadri, Hector M. González, Myriam Fornage   +20 more
wiley   +1 more source

Extracellular vesicle‐packaged lncRNA from cancer‐associated fibroblasts promotes immune evasion by downregulating HLA‐A in pancreatic cancer

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer‐associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated the role of CAF‐derived extracellular vesicle (EV)‐packaged long non‐coding RNAs (lncRNAs) in immune evasion ...
Hanming Yao, Chengzhi Huang, Jinmao Zou, Weiling Liang, Yue Zhao, Kege Yang, Ziyi Zhong, Shurui Zhou, Jiajia Li, Yaqing Li, Lishu Xu, Kaihong Huang, Guoda Lian   +12 more
wiley   +1 more source

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

Cancer Medicine, Volume 13, Issue 7, April 2024.
The m6A methylation is catalysed by the writer complex and the demethylation is catalysed by the erasers. Different readers proteins determine the fate of m6A modification. These proteins have increasingly been recognised as targets for cancer therapy.
Angel Guan, Justin J.‐L. Wong
wiley   +1 more source

The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022

Alzheimer's &Dementia, Volume 20, Issue 1, Page 652-694, January 2024.
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful ...
Dallas P. Veitch, Michael W. Weiner, Melanie Miller, Paul S. Aisen, Miriam A. Ashford, Laurel A. Beckett, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, Susan M. Landau, John C. Morris, Kwangsik T. Nho, Rachel Nosheny, Ozioma Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, for the Alzheimer's Disease Neuroimaging Initiative   +22 more
wiley   +1 more source

Roles of the CCR4‐Not complex in translation and dynamics of co‐translation events

WIREs RNA, Volume 15, Issue 1, January/February 2024.
Not5 ribosome binding ensures co‐translational organellar targeting and protein assembly. Prolonged ribosome pausing leading to post‐translocation ribosomes with empty A and E sites allows Not5 ribosome binding. This Not5 ribosome binding is key for co‐translational events such as organellar targeting or assembly of proteins.
Martine A. Collart, Léna Audebert, Martin Bushell   +2 more
wiley   +1 more source

Co-immunoprecipitation of the Cnot7 mutants confirming the specific disruption of interaction with TOB1 by the E247A/Y260A mutant (A).

, 2016
Co-immunoprecipitation of the Cnot7 mutants confirming the specific disruption of interaction with CNOT1 by the M141R mutant (B). Western blot confirming the equal expression of Cnot7 constructs in cells used for spontaneous metastasis assays (C).
Farhoud Faraji (135917), Howard H. Yang (252751), G. Sebastian Winkler (847958), Ying Hu (14950), Markus Hafner (186692), Kent W. Hunter (135937), Maxwell P. Lee (31055)   +6 more
core   +1 more source