Results 51 to 60 of about 86,048 (164)

Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex

Frontiers in Genetics, 2013
The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler, Dario L Balacco   +1 more
doaj   +1 more source

Gestational Valproate Exposure Induces Tissue‐Specific Transcriptomic Changes in the Neonatal Brain and Choroid Plexus in a Rat Model of Epilepsy, GAERS

European Journal of Neuroscience, Volume 61, Issue 10, May 2025.
This study used a rat model of absence epilepsy, Genetic Absence Epilepsy Rat from Strasbourg (GAERS), to investigate the effects of gestational valproate exposure on early postnatal brain cortex and lateral choroid plexus transcriptomes. Results showed distinct differential gene expression patterns between the two tissues, with substantially more ...
Fiona Qiu, Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Norman R. Saunders   +4 more
wiley   +1 more source

Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Spaceflight negatively influences the function of cartilage tissue in vivo. In vitro human chondrocytes exhibit an altered gene expression of inflammation markers after a two-hour exposure to vibration.
Ronald Lützenberg, Kendrick Solano, Christoph Buken, Jayashree Sahana, Stefan Riwaldt, Sascha Kopp, Marcus Krüger, Herbert Schulz, Kathrin Saar, Norbert Huebner, Ruth Hemmersbach, Johann Bauer, Manfred Infanger, Daniela Grimm, Markus Wehland   +14 more
doaj   +1 more source

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors [PDF]

, 2013
Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its ...
Aerbajinai, Albers, Aslam, Avram, Avram, Baker, Benoit, Berry, Chun Ming Chan, Cismasiu, Cismasiu, Collins, Coulthard, Cristina Montiel-Duarte, David M. Heery, Escher, Filipe, Frances R. Wadelin, Gui, Gurnell, Hall, Heery, Heery, Hilary M. Collins, Hu, Huang, Huggins, Joel Fulton, Kalkhoven, Kiefer, Kobayashi, Kobayashi, Kruse, Kuo, le Maire, Leid, Lettre, Liberati, Lim, Lin, Lin, Liu, Marban, Menzel, Monaghan, Nagy, Nakamura, Neetu Bharti, Nigel P. Mongan, Paula M. Moran, Peng, Perissi, Rohr, Rouleau, Sankaran, Sankaran, Sankaran, Satterwhite, Senawong, Sheppard, Song, Takezawa, Topark-Ngarm, Torchia, Tsai, Uda, Wang, Watson, Xie, Xie, Xu, Xu, Xu, Yu, Zhang, Zhu   +75 more
core   +3 more sources

Multi‐omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes

Cell Proliferation, Volume 58, Issue 3, March 2025.
Construct postovulatory ageing protein map to deeply analyse the dynamic changes of postovulatory ageing proteins. DCP1A accumulation accelerates maternal mRNA decay in postovulatory‐aged oocytes. SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes.
Li Kong, Yutian Gong, Yongyong Wang, Mengjiao Yuan, Wenxiang Liu, Heyang Zhou, Xiangyue Meng, Xinru Guo, Yongbin Liu, Yang Zhou, Teng Zhang   +10 more
wiley   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity [PDF]

, 2007
BACKGROUND: Recently, several populations of postnatal stem cells, such as multipotent adult progenitor cells (MAPCs), have been described that have broader differentiation ability than classical adult stem cells.
Ulloa-Montoya, Fernando, Kidder, Benjamin L., Pauwelyn, Karen A., Chase, Lucas G., Luttun, Aernout, Crabbe, Annelies, Geraerts, Martine, Sharov, Alexei A., Piao, Yulan, Ko, Minoru S.H., Hu, Wei-Shou, Verfaillie, Catherine   +11 more
core   +2 more sources

Methyltransferase‐Like 3‐Mediated N6‐Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.
ABSTRACT Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats.
Dongqiong Xiao, Deshuang Zhang, Yi Qu, Xiaojuan Su   +3 more
wiley   +1 more source

Osteoarthritis Bone Marrow MSCs Retain Regenerative Competence and Chemokine Responsiveness for Drug‐Based In Situ Tissue Engineering

Stem Cells International, Volume 2025, Issue 1, 2025.
Background Mesenchymal stromal cells (MSCs) support tissue repair in osteoarthritis (OA), with migration to damaged tissue being a key strategy in in situ tissue engineering. Their regenerative potential depends on factors such as differentiation, level of senescence, and responsiveness to signaling molecules.
Julia Sonnleitner, Katja Gulich, Axel Pruss, Carsten Perka, Angelika Gursche, Daniel Kendoff, Michael Sittinger, Shabnam Hemmati-Sadeghi, Tilo Dehne, Yuriy Petrenko   +9 more
wiley   +1 more source

The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]

, 2017
YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara, Carrieri, Claudia, Di Giacomo, Monica, Enright, Anton J, Ivanova, Ivayla, Monahan, Jack, Moreira, Pedro N, Morgan, Marcos, Much, Christian, O'Carroll, Dónal   +9 more
core   +3 more sources