Results 111 to 120 of about 19,252 (225)

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

EVOLUTION OF THE CIRCADIAN CLOCK IN EXTREME ENVIRONMENT: LESSONS FROM CAVEFISH. [PDF]

, 2010
Evolution has been strongly influenced by the daily cycles of temperature and light imposed by the rotation of the Earth. Fascinating demonstrations of this are seen in extreme environments such as caves where some animals have remained completely ...
Cavallari, Nicola
core  

BPM31510 Increases the CoQ Pool in Chemically Induced CoQ‐Deficient Cells, CoQ‐Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Graphical abstract illustrating the in vitro and in vivo experimental workflow used to compare BPM31510, a nanoliposomal formulation of oxidized CoQ10, with conventional CoQ10. Chemically induced CoQ‐deficient SH‐SY5Y cells, CoQ‐deficient patient fibroblasts, and C57BL/6J mice receiving oral CoQ10 or intraperitoneal BPM31510 were subjected to plasma ...
Juan J. Aristizabal‐Henao, Sarah R. Wessel, Sylwia A. Stopka, Srada Karmacharya, Devon Van Cura, Alba Pesini, Kelsey R. Nickerson, Kashni Grover, Oksana Zavidij, Archna Ravi, Andressa L. Mota, Kenneth M. Rosen, Maria‐Dorothea Nastke, Megan K. Cox, Niven R. Narain, Vijay Modur, Catarina M. Quinzii, Stephane Gesta, Michael A. Kiebish   +18 more
wiley   +1 more source

Oxidative Stress and Mitochondrial Injury in Chronic Multisymptom Conditions: From Gulf War Illness to Autism Spectrum Disorder [PDF]

, 2012
Background: Overlapping chronic multisymptom illnesses (CMI) include Chronic Fatigue Syndrome (CFS), fibromyalgia, irritable bowel syndrome, multiple chemical sensitivity, and Gulf War illness (GWI), and subsets of autism spectrum disorder (ASD).
Beatrice A. Golomb
core   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Genome‐Wide Association Studies for 24 Hematological Traits in Production Pigs Before and After Weaning

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT Hematological traits are essential indicators of an animal's immune status and overall health, reflecting both physiological and pathological conditions. The complete blood count (CBC), a commonly used clinical test, evaluates the concentrations, proportions, and characteristics of various blood cell parameters, providing insights into an ...
Jiahong Sun, Emil Ibragimov, Malene Kjelin Morsing, Martin Peter Rydal, Lise Nikolic Nielsen, Zexi Cai, Jens Peter Nielsen, Merete Fredholm, Peter Karlskov‐Mortensen   +8 more
wiley   +1 more source

An Oral Antioxidant Formulation Delaying and Potentially Reversing [PDF]

, 2015
This is the final published version. It first appeared at http://clinmedlibrary.com/articles/ijdcr/ijdcr-2-023.php?jid=ijdcr.Background: The majority of dogs with diabetes mellitus develop blinding mature cataracts through the action of the enzyme aldose
Colitz, Carmen, Fitchie, Angus, Williams, David   +2 more
core   +1 more source

A Case Series of Sudden Death in Children Aged 12 Months to 4 Years From LPIN1 Deficiency and PPA2 Deficiency in Queensland

Journal of Paediatrics and Child Health, EarlyView.
Sophie Manoy, Sally Smith, Marita Smith, Catherine Atthow, Janette Spicer, Matthew Lynch, Michelle Lipke, Julie A. McEniery, David Coman, Anita Inwood, Jim McGill, Carolyn Bursle   +11 more
wiley   +1 more source

Decades of Misdiagnosis as Myasthenia Gravis: Late‐Onset POLG‐Related Ophthalmoplegia Unveiled by Whole‐Genome Sequencing

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT A 55‐year‐old male developed POLG‐related ophthalmoplegia in 2015 and was misdiagnosed with seronegative myasthenia gravis for 10 years. Whole‐genome sequencing identified compound heterozygous POLG mutations, highlighting its value in diagnosing refractory neuromuscular disorders.
Tanli Lu, Huadong Lv, Xiaodan Luo, Xiuying Liu   +3 more
wiley   +1 more source

Guidelines for nutrition in adults with head and neck cancer: The American Society for Parenteral and Enteral Nutrition

Journal of Parenteral and Enteral Nutrition, Volume 50, Issue 3, Page 274-338, April 2026.
Abstract Background Head and neck cancer represents the seventh most common cancer diagnosis globally. Maintaining sufficient nutrition is important for preventing malnutrition (undernutrition) and muscle wasting, which contribute to worse outcomes, although many patients are unable to maintain adequate oral intake throughout treatment.
Nicole Kiss, Merran Findlay, Jacqui Frowen, Whitney E. Lewis, Jeannine Mills, Anurag K. Singh, David D. Church, Jacob T. Mey, Sarah Peterson, Kathleen Aguzzi, Sarah Bellini, Maria Paula Villela Coelho, Laura Cordwin, Michael Duffy, Shanna Hager, Manpreet S. Mundi, Michael Owen‐Michaane, Kathleen Price, Heather Stanner, Bridget Storm, Malika Udagedara, Liam McKeever   +21 more
wiley   +1 more source