Results 81 to 90 of about 19,218 (217)

Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study [PDF]

Pharmacia
Vestibular migraine (VM) has conventionally been treated through acute migraine-aborting therapeutic interventions and prevention to reduce migraines’ occurrence, length and intensity.
Ala Abu-Zaid, Sawsan Abu-Zaid, Muna Barakat, Rashed Al-Huniti, Hamzeh Khair   +4 more
doaj   +3 more sources

Cardiac metabolism — A promising therapeutic target for heart failure [PDF]

, 2017
Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality.
Frenneaux, Michael P, Loudon, Brodie L, Madhani, Melanie, Noordali, Hannah   +3 more
core   +2 more sources

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

The Effect of Systemic Administration of Co-enzyme Q10 on Orthodontic Relapse in a rabbit model

Alexandria Dental Journal, 2021
ABSTRACT Introduction: Several pharmacological agents have been investigated for their ability to reduce orthodontic relapse. Objective: The current research was performed to test the short term influence of systemic Co-enzyme Q10 administration on post-orthodontic relapse in rabbits.
ahmed madian, essam abdallah, Nadia El Harouni, Shadia Abdelmajeed   +3 more
openaire   +1 more source

Influence of estimated training status on anti and pro-oxidant activity, nitrite concentration, and blood pressure in middle-aged and older women [PDF]

, 2017
The purpose of this study was to compare the association between anti and pro-oxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of
Amaral, Sandra L., Brito, Janaina de Oliveira, da Silva, Roberta F., De Angelis, Kátia, Dias, Danielle da Silva, Jacomini, André M., Llesuy, Susana Francisca, Monteiro, Henrique L., Zago, Anderson S.   +8 more
core   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad

JLUMHS, 2017
OBJECTIVE: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned
Farheen Shaikh , Tazeen Shah, Shafaq Ansari, Sanum Dahri   +3 more
doaj   +1 more source

High levels of ubidecarenone (oxidized CoQ10) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells

Scientific Reports, 2020
Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of reactive oxygen species (ROS) leading to higher oxidative stress. The elevated ROS levels suggest a vulnerability to excess prooxidant loads leading to selective cell death,
Jiaxin Sun, Chirag B. Patel, Taichang Jang, Milton Merchant, Chen Chen, Shiva Kazerounian, Anne R. Diers, Michael A. Kiebish, Vivek K. Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R. Narain, Seema Nagpal, Lawrence Recht   +13 more
doaj   +1 more source

Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice

Brain, Behavior, & Immunity - Health, 2020
Tau phosphorylation is associated with cognitive impairment in young mice. However, the underlying mechanism and targeted interventions remain mostly unknown.
Jie Zhang, Yuanlin Dong, Lining Huang, Xiaoming Xu, Feng Liang, Sulpicio G. Soriano, Yiying Zhang, Zhongcong Xie   +7 more
doaj   +1 more source