Results 1 to 10 of about 23,789 (261)

Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment [PDF]

International Journal of Pharmaceutics: X
Emodin (EMO) shows therapeutic promise for ulcerative colitis (UC), yet its clinical utility is hampered by low bioavailability. To rationally overcome this limitation, this study employed cocrystal engineering, strategically selecting ...
Meiru Liu, Yinru Jiang, Penghui Yuan, Shuang Li, Baoxi Zhang, Xia Zhou, Bin Su, Yifei Xie, Dezhi Yang, Linglei Kong, Li Zhang, Yang Lv, Guanhua Du   +12 more
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Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties [PDF]

, 2014
YesPolymorphism of crystalline drugs is a common phenomenon. However, the number of reported polymorphic cocrystals is very limited. In this work, the synthesis and solid state characterisation of a polymorphic cocrystal composed of sulfadimidine (SD ...
Alhalaweh, Anne Marie Healy, Apperley, Babu, Bethune, Bhatt, Blagden, Caira, Caira, Caira, Cheary, Christine Grossjohann, Coelho, David, Dolores R. Serrano, Forbes, Friščić, Good, Grossjohann, Healy, Karki, Krzysztof J. Paluch, Lapidus, Le Bail, Liana Vella-Zarb, Lidia Tajber, Loureiro, Lover, Macrae, Miroshnyk, Murikipudi, Nehm, Owen I. Corrigan, Panagiotis Manesiotis, Peter O’Connell, Rietveld, Serrano Lopez, Tajber, Thomas McCabe, Vishweshwar, Wahl, Wahl, Wermuth   +42 more
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Daidzein-betaine cocrystal alleviates high-energy and low-protein diet induced fatty liver hemorrhagic syndrome in laying hens through gut-liver axis [PDF]

Poultry Science
Fatty liver hemorrhagic syndrome (FLHS) severely endangers the health and productivity of laying hens, marked by hepatic steatosis and impaired lipid metabolism. Daidzein-betaine cocrystal improves lipid metabolism in the diet-induced obesity mice.
Yanling Sun, Tiantian Wang, Yu Zhang, Ning Ma, Xinghua Zhao, Xin He   +5 more
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Triethylamine vapor-induced cyclization reaction in cocrystals leading to cocrystal-to-polycrystal transformation [PDF]

Nature Communications
The structural transformation of crystals triggered by external stimuli is a fascinating area in materials science and supramolecular chemistry. Despite the potential of organic reactions driving crystal conversions, its exploration remains limited ...
Ling Zhu, Xiaoli Zhao, Yanfei Niu, Lianrui Hu, Weitao Dou, Hai-Bo Yang, Lin Xu, Ben Zhong Tang   +7 more
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Crystal structure, Hirshfeld surface and intermolecular interaction energy analysis of the halogen-bonded 1:1 cocrystal 1-bromo-3,5-dinitrobenzene–N,N-dimethylpyridin-4-amine [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The structure of the 1:1 cocrystal formed between 1-bromo-3,5-dinitrobenzene and N,N-dimethylpyridin-4-amine that features a C—Br...N halogen bond is reported. The cocrystal, C6H3BrN2O4·C7H10N2, crystalizes in the monoclinic space group P21/c with Z = 4.
Eric Bosch
doaj   +2 more sources

Competitive cocrystallization and its application in the separation of flavonoids

IUCrJ, 2021
Recently, cocrystallization has been widely employed to tailor physicochemical properties of drugs in the pharmaceutical field. In this study, cocrystallization was applied to separate natural compounds with similar structures.
Yanming Xia, Yuanfeng Wei, Hui Chen, Shuai Qian, Jianjun Zhang, Yuan Gao   +5 more
doaj   +1 more source

Molecular Structure, Spectral Investigations, Hydrogen Bonding Interactions and Reactivity-Property Relationship of Caffeine-Citric Acid Cocrystal by Experimental and DFT Approach

Frontiers in Chemistry, 2021
The pharmaceutical cocrystal of caffeine-citric acid (CAF-CA, Form II) has been studied to explore the presence of hydrogen bonding interactions and structure-reactivity-property relationship between the two constituents CAF and Citric acid.
Priya Verma, Anubha Srivastava, Karnica Srivastava, Poonam Tandon, Manishkumar R. Shimpi, Manishkumar R. Shimpi   +5 more
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Morphology and properties of CL-20/MTNP cocrystal prepared via facile spray drying

FirePhysChem, 2023
Cocrystal of 2,4,6,8,10,12-hexaazaisowurtzitane/1-methyl-3,4,5-trinitropyrazole (CL-20/MTNP) in a 1:1 molar ratio is a promising energetic material, since it combines the superior detonation performance of CL-20 and good mechanical sensitivity of MTNP ...
Xueyan Zhao, Zongwei Yang, Shen Qiao, Junyu Piao, Hongzhen Li   +4 more
doaj   +1 more source

Terahertz and Raman Spectroscopic Investigation of Monohydrate Cocrystal of Antitubercular Isoniazid with Protocatechuic Acid

Pharmaceutics, 2021
Pharmaceutical cocrystal provides an alternative modification strategy for the formulation development of drugs owning to their potential ability to improve the physicochemical properties of active pharmaceutical ingredients (APIs) efficiently by ...
Yanhua Bo, Jiyuan Fang, Ziming Zhang, Jiadan Xue, Jianjun Liu, Zhi Hong, Yong Du   +6 more
doaj   +1 more source

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Pharmaceutics, 2023
A solvate cocrystal of the antimicrobial norfloxacin (NFX) was formed by using isonicotinamide (INA) as a coformer with the solvent evaporation technique. The cocrystal formation was confirmed by performing solid-state characterization techniques.
Samantha Nascimento Gomes, Isabela Fanelli Barreto Biscaia, Diana Schon Lopes, Mariana Mengarda, Fábio Seigi Murakami, Paulo Renato Oliveira, Larissa Sakis Bernardi   +6 more
doaj   +1 more source