Results 51 to 60 of about 23,789 (261)

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Pharmaceutics, 2021
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential.
Sangho Cho, Jeongwook Lee, Yongwon Yoo, Minyong Cho, Seil Sohn, Beom-Jin Lee   +5 more
doaj   +1 more source

Trapping virtual pores by crystal retro-engineering [PDF]

, 2015
Stable guest-free porous molecular crystals are uncommon. By contrast, organic molecular crystals with guest-occupied cavities are frequently observed, but these cavities tend to be unstable and collapse on removal of the guests—this feature has been ...
AI Day, Andrew I. Cooper, AP Nelson, CB Aakeroy, CG Bezzu, D MacDowell, D Musumeci, DB Kitchen, DW Lewis, FH Herbstein, G Zhang, G Zhang, GM Sheldrick, GM Sheldrick, GR Desiraju, H Deng, H Nowell, J Tian, James T. A. Jones, JE Parker, JL Atwood, JR Holst, JTA Jones, Kim E. Jelfs, L Travaglini, Linjiang Chen, Lloyd M. Robeson, M Eddaoudi, M Liu, M Mastalerz, M Mastalerz, M Mastalerz, MA Little, Marc A. Little, Marc Schmidtmann, MGB Drew, Michael E. Briggs, MJ Bojdys, MW Schneider, PK Thallapally, R Natarajan, R Natarajan, R Pophale, S Tothadi, Samantha Y. Chong, SL Price, SP Thompson, T Grecu, T Hasell, T Hasell, T Tozawa, Tom Hasell, WL Jorgensen, Y Jin, Y Jin   +54 more
core   +1 more source

Air-Stable Cyclohexasulfur as Cocrystal [PDF]

Crystal Growth & Design, 2012
A new stable cyclohexasulfur (cyclo-S6) was discovered in the crystal of 3,5-diphenyl-1,2,4-dithiazol-1-ium (dpdti); dpdti was synthesized via an oxidation reaction of thiobenzamide with iodine in ...
Kunihisa Sugimoto, Hiroshi Uemachi, Masahiko Maekawa, Akihiko Fujiwara   +3 more
openaire   +1 more source

Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin

Crystals
This study explores the co-crystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal.
Camila Caro Garrido, Marie Vandooren, Koen Robeyns, Damien P. Debecker, Patricia Luis, Tom Leyssens   +5 more
doaj   +1 more source

Synthesis, Characterization and Morphological Study of Nicotinamide and p-Coumaric Acid Cocrystal

Indonesian Journal of Chemistry, 2020
Cocrystallization is one of the potent methods used to modify the physicochemical properties of drugs. Cocrystal of nicotinamide (NIC):p-coumaric acid (COU) was synthesized by a slow evaporation method using acetonitrile.
Mohamad Nor Amirul Azhar Kamis, Hamizah Mohd Zaki, Nornizar Anuar, Mohammad Noor Jalil   +3 more
doaj   +1 more source

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts [PDF]

, 2017
This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization.
Connor, Lauren E., MacFhionnghaile, Pól, McGinty, John, Oswald, Iain D. H., Sefcik, Jan, Svoboda, Vaclav   +5 more
core   +1 more source

Cocrystal construction between the ethyl ester with parent drug of diclofenac: structural, stability, and anti-inflammatory study

Heliyon, 2019
This study aimed to collect the crystallographic data of ethyl diclofenac and discover a cocrystal from this ester with its parent, diclofenac acid, and to investigate their physicochemical properties and anti-inflammation activity.
Ilma Nugrahani, Dwi Utami, Yuda Prasetya Nugraha, Hidehiro Uekusa, Rahel Hasianna, Aisyah Amalia Darusman   +5 more
doaj   +1 more source

Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance [PDF]

, 2011
Cocrystals have been increasingly recognized as an attractive alternative delivery form for solid drug products. In this work, Raman spectroscopy, X-ray powder diffraction/X-ray crystallography, and differential scanning calorimetry have been used to ...
Aakeroy, Berry, Bettinetti, Bickley, Caira, Caira, Childs, Desiraju, El-Shahawy, Etter, Etter, Etter, Etter, H. G. M. Edwards, He, I. J. Scowen, Karki, Kauffman, Lemmerer, M. A. Elbagerma, Morissette, Myz, Nangia, Nichols, Oswald, Oswald, Rao, Rodriguez-Spong, Schantz, Sheikh, T. Munshi, Vishweshwar, Vishweshwar, Wenger, Weyna   +34 more
core   +1 more source

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

Indonesian Journal of Chemistry, 2019
Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid ...
Yudi Wicaksono, Dwi Setyawan, Siswandono Siswandono, Tri Agus Siswoyo   +3 more
doaj   +1 more source

Site selectivity of halogen oxygen bonding in 5- and 6-haloderivatives of uracil [PDF]

, 2019
Seven 5-and 6-halogenated derivatives of uracil or 1-methyluracil (halogen = Cl, Br, I) were studied by single crystal X-ray diffraction. In contrast with pure 5-halouracils, where the presence of N-H…O and C-H…O hydrogen bonds prevents the formation ...
Portalone, Gustavo
core   +1 more source