Results 81 to 90 of about 16,526 (214)
Molecules, 2019 Vibrational modes of pyrazinamide (PZA), 3-hydroxybenzoic acid (3-hBA), and their cocrystal were characterized using terahertz time-domain (THz-TDS) and Raman vibrational spectroscopic techniques.
Qiqi Wang, Jiadan Xue, Zhi Hong, Yong Du
doaj +1 more source
European Journal of Organic Chemistry, EarlyView.The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus +24 more
wiley +1 more source
Bioavailability of indomethacin-saccharin cocrystals
Journal of Pharmacy and Pharmacology, 2010 Abstract Objectives Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. However, the in-vivo bioavailability of cocrystals has rarely been addressed.
Min-Sook, Jung +6 more
openaire +2 more sources
Information &Functional Materials, EarlyView.A new molecular cocrystal shows D‐A alternative molecular stacking, cyan‐blue photoluminescence with lifetime of 19.76 ns, and two‐photon absorption enabled emission under laser excitation between 720 and 880 nm. Theoretical calculations reveal its static dipole moment of 2.84 D, CT character in the ground, S1, and S2 excited states, and the TPA ...
Weigang Zhu +4 more
wiley +1 more source
ACS Omega, 2020 Nano-CL-20/TNT cocrystal explosive was successfully prepared by mechanical ball milling with 0.38 mm grinding beads. The micromorphology and particle size of cocrystal explosive were characterized by scanning electron microscopy.
Yubing Hu +7 more
semanticscholar +1 more source
Medicine Bulletin, EarlyView.ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang +5 more
wiley +1 more source
ChemistryOpen, EarlyView.Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari +7 more
wiley +1 more source
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Propellants, Explosives, Pyrotechnics, EarlyView.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source