Tuning the Pharmacokinetic Performance of Quercetin by Cocrystallization [PDF]
Crystal Growth & Design, 2023 Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤20 μg/mL) and poor oral bioavailability have impeded its potential utility and clinical development. In this context, cocrystallization has emerged as a useful method for improving the
Molly M. Haskins +9 more
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Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Urszula Izabela Maciołek +4 more
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Achieving Balanced Energetics through Cocrystallization [PDF]
Angewandte Chemie, 2019 AbstractAchieving energetic materials with a balanced ratio of oxidant to fuel is a challenge that has been difficult to meet through molecular synthesis. The alternative approach, composite formulation, fails to achieve intimate association of the components to the detriment of performance.
Michael K. Bellas, Adam J. Matzger
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Cocrystal Engineering of Conjugated Polymer Blends via External Electric Field for Enhanced Charge Transport [PDF]
Advanced ScienceCocrystal engineering that combines different components into cocrystals renders the newly formed materials with innovative and multifunctional properties. However, this strategy is rather limitedly explored in conjugated polymer blends.
Yanan Guo, Hao Zheng, Juan Peng
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Supramolecular hair dyes : a new application of cocrystallization [PDF]
CrystEngComm, 2016 The manuscript presents the first report of hair dyes of various colors formed by the cocrystallization reactions. Unlike the most popular oxidative hair dye (OHD) products, these dyes are NH3 free and do not require H2O2 as a color developer.
Delori, Amit +2 more
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Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts [PDF]
, 2017 This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization.
Connor, Lauren E. +5 more
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New Cocrystals of Antipsychotic Drug Aripiprazole: Decreasing the Dissolution through Cocrystallization [PDF]
Molecules, 2021 Cocrystallization is an important route to tuning the solubility in drugs development, including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol (RSV) and kaempferol (KAE), ARI-RSV, ARI2-RSV1·MeOH, ARI-KAE, ARI-KAE·EtOH ...
Wenwen Liu +6 more
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Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
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Cocrystallization of ubiquitin–deubiquitinase complexes through disulfide linkage [PDF]
Acta Crystallographica Section D Structural Biology, 2023 Structural characterization of the recognition of ubiquitin (Ub) by deubiquitinases (DUBs) has largely relied on covalent complexation of the DUB through its catalytic cysteine with a Ub C-terminal electrophile. The Ub electrophiles are accessed through intein chemistry in conjunction with chemical synthesis.
Kristos I. Negrón Terón +1 more
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Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acid [PDF]
, 2015 Solid-state cocrystallisation is of contemporary interest, because it offers an easy and efficient way to produce cocrystals, which are recognized as prospective pharmaceutical materials.
Fabian, Laszlo +5 more
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