Results 31 to 40 of about 10,442 (249)
Cocrystallization of Nutraceuticals
Crystal Growth & Design, 2015 Cocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation.
Sinha, Abhijeet S. +2 more
openaire +2 more sources
Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
Pharmaceutics, 2022 Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL).
Yihua Jiang +7 more
doaj +1 more source
2-Amino-1-methyl-1H-imidazol-4(5H)-one dimethyl sulfoxide monosolvate [PDF]
, 2010 In the title compound, C4H7N3O·C2H6OS, creatinine [2-amino-1-methyl-1H-imidazol-4(5H)one] exists in the amine form. The ring is planar (r.m.s. deviation for all non-H atoms = 0.017 Å).
Tutughamiarso, Maya Oktavia +1 more
core +1 more source
Crystals, 2016 Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development.
Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
doaj +1 more source
Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs [PDF]
, 2014 The aim of the study is to increase the bioavailability of itraconazole (ITRA) using nanosized cocrystals prepared via wet milling of ITRA in combination with dicarboxylic acids.
Adriaensens, Peter +7 more
core +1 more source
Pharmaceutics, 2021 A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael +4 more
doaj +1 more source
Pharmaceutical Cocrystals—A Review
Proceedings, 2021 The design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and ...
Sheetal S. Buddhadev, Kevin C. Garala
doaj +1 more source
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. [PDF]
, 2019 Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication.
Du Bois, J +4 more
core +2 more sources
Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon
Frontiers in Chemistry, 2022 The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers.
Vineet Kumar +5 more
doaj +1 more source
The curious case of (caffeine).(benzoic acid): how heteronuclear seeding allowed the formation of an elusive cocrystal [PDF]
, 2013 Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry and materials science. A variety of methods exist for the preparation of cocrystals yet, some promising cocrystal phases have proven to be intractable synthetic ...
Bucar, Dejan-Kresimir +8 more
core +1 more source