Results 41 to 50 of about 10,442 (249)
Improving Biopharmaceutical Properties of Vinpocetine Through Cocrystallization [PDF]
Journal of Pharmaceutical Sciences, 2016 Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved pharmacokinetic properties is highly desirable.
GOLOB, SAMUEL +7 more
openaire +4 more sources
Crystals, 2023 Pyruvic acid is an organic compound used in various fields (e.g., the pharmaceutical, cosmetic, food, and chemical industries) and subject to constantly growing demand.
Camila Caro Garrido +4 more
doaj +1 more source
Crystallization and preliminary X-ray analysis of neoagarobiose hydrolase from Saccharophagus degradans 2-40 [PDF]
, 2009 Many agarolytic bacteria degrade agar polysaccharide into the disaccharide unit neoagarobiose [O-3,6-anhydro-α-L-galactopyranosyl-(1→3)-D-galactose] using various β-agarases.
Araki +18 more
core +2 more sources
Preparation and Characterization of Highly Water Soluble Curcumin – Dextrose Cocrystal [PDF]
Journal of Pure and Applied Chemistry Research, 2018 Curcumin is a natural food colorant isolated from rhizomes of turmeric (Curcuma longa). Despite its many favorable properties, curcumin is practically insoluble in water and relatively unstable, thus limiting its application.
Katherine Kho +2 more
doaj +1 more source
Cocrystallization of Antifungal Compounds Mediated by Halogen Bonding
Crystal Growth & Design, 2023 The application of halogen bonding in pharmaceutical chemistry remains a challenge. In this work, novel halogen-bonded cocrystals based on azole antifungal active pharmaceutical ingredients (APIs) and the ditopic molecule 1,4-diiodotetrafluorobenzene are reported.
Mónica Benito +2 more
openaire +4 more sources
Process monitoring and visualization solutions for hot-melt extrusion : a review [PDF]
, 2013 Objectives: Hot-melt extrusion (HME) is applied as a continuous pharmaceutical manufacturing process for the production of a variety of dosage forms and formulations.
De Beer, Thomas +3 more
core +2 more sources
Angewandte Chemie, EarlyView.Compositionally engineered mixed solvated cocrystals enable modulation of thermosalient actuation. Guest ratio controls thermosalient temperature and propulsion intensity, providing a tunable platform for designing crystalline systems that exhibit stimuli‐responsive mechanical motion.
Ernesto A. Hernández‐Morales +5 more
wiley +2 more sources
Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
Frontiers in Pharmacology, 2021 The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size
Ravi Kumar Bandaru +7 more
doaj +1 more source
Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]
, 2013 The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Alcasabas +40 more
core +1 more source
Mechanochemical Synthesis of Multicomponent Crystals: One Liquid for One Polymorph? A Myth to Dispel [PDF]
, 2016 Identifying as many polymorphs as possible for a molecular compound is important in the design of materials with desired properties. In this paper we demonstrate, using a simple experimental procedure, how the amount of liquid present during liquid ...
Bernstein J. +4 more
core +3 more sources