Are oxygen and sulfur atoms structurally equivalent in organic crystals? [PDF]
, 2016 New guidelines for the design of structurally equivalent molecular crystals were derived from structural analyses of new cocrystals and polymorphs of saccharin and thiosaccharin, aided by a computational study. The study shows that isostructural crystals
Buanz, ABM +6 more
core +1 more source
Near‐Infrared Cocrystal Nanofluorophore with Enhanced Two‐Photon Absorption Cross Sections
Advanced Science, EarlyView.In this study, organic cocrystal nanoparticles (BP4TC‐NPs) were prepared via a nanoprecipitation method using an amphiphilic surfactant. The resulting cocrystal nanoparticles exhibit exceptional nonlinear optical properties and bioimaging capabilities.
Liangmeng Hao +8 more
wiley +1 more source
Four Novel Pharmaceutical Cocrystals of Oxyresveratrol, Including a 2 : 3 Cocrystal with Betaine
Chemical and Pharmaceutical Bulletin, 2021 Cocrystal engineering can alter the physicochemical properties of a drug and generate a superior drug candidate for formulation design. Oxyresveratrol (ORV) exhibits a poor solubility in aqueous environments, thereby resulting in a poor bioavailability.
Nasa, Sakamoto +6 more
openaire +3 more sources
Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance [PDF]
, 2011 Cocrystals have been increasingly recognized as an attractive alternative delivery form for solid drug products. In this work, Raman spectroscopy, X-ray powder diffraction/X-ray crystallography, and differential scanning calorimetry have been used to ...
Aakeroy +34 more
core +1 more source
Mechanochromic Organic Materials: Molecular Mechanisms and Multidimensional Applications
Advanced Physics Research, EarlyView.Mechanochromic (MC) organic materials change color in response to mechanical force. This review elucidates the molecular mechanisms (e.g., aggregation‐induced emission, AIE) and explores their multidimensional applications in sensors, anti‐counterfeiting, biomedical devices, and structural health monitoring, providing a roadmap for future smart ...
Xiaozhe Yin +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel +5 more
wiley +1 more source
Bioavailability of indomethacin-saccharin cocrystals
Journal of Pharmacy and Pharmacology, 2010 Abstract Objectives Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. However, the in-vivo bioavailability of cocrystals has rarely been addressed.
Min-Sook, Jung +6 more
openaire +2 more sources
Investigation of an amide-pseudo amide hydrogen bonding motif within a series of theophylline:amide cocrystals [PDF]
, 2016 The pharmaceutically active compound theophylline (T) was cocrystallised with the amides formamide (1), acetamide (2), N-methylformamide (3), N,N-dimethylformamide (4), benzamide (5) and pyrazinamide (6), with systems T:1, T:5 and T:6 displaying ...
Davis R. E. +6 more
core +3 more sources
Back Cover: Hyperbranched Microwire Networks of Organic Cocrystals with Optical Waveguiding and Light‐Harvesting Abilities (Angew. Chem. Int. Ed. 52/2021) [PDF]
, 2021 Zuofang Feng +4 more
openalex +1 more source
Next Generation Hosts for Protein Recognition, Assembly and More
Chemistry – A European Journal, EarlyView.The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley +1 more source