Results 91 to 100 of about 11,037 (206)

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source

Crystallographic Modification of Rosuvastatin Calcium: Formulation, Characterization and Pharmacokinetic Evaluation for Enhanced Dissolution, Stability and Bioavailability

Scientia Pharmaceutica
Rosuvastatin calcium is a promising lipid-lowering agent and the drug of choice in hyperlipidemia. Conventional solid oral delivery of rosuvastatin is limited by its poor solubility and ultimately poor bioavailability.
Deepak Kulkarni, Sanjay Pekamwar
doaj   +1 more source

Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]

, 2016
Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...

core   +2 more sources

Bioavailability of indomethacin-saccharin cocrystals

Journal of Pharmacy and Pharmacology, 2010
Abstract Objectives Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. However, the in-vivo bioavailability of cocrystals has rarely been addressed.
Min-Sook, Jung, Jeong-Soo, Kim, Min-Soo, Kim, Amjad, Alhalaweh, Wonkyung, Cho, Sung-Joo, Hwang, Sitaram P, Velaga   +6 more
openaire   +2 more sources

Semiconducting Quasi One‐Dimensional (PbBr2)[Pb2P14]2, a Lead Bromide Adduct and Violet Phosphorus Derivative

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The quasi‐one‐dimensional semiconductor Pb5Br2P28 was examined in terms of its structural and electronic properties. Single‐crystal X‐ray diffraction (SC‐XRD) and Raman spectroscopy support its description as neutral [Pb2P14] and [PbBr2] units. Combined with its semiconducting properties and high flexibility, Pb5Br2P28 emerges as a promising candidate ...
Kathrin Vosseler, Felipe Jacques Lima Duarte, Tom Nilges   +2 more
wiley   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis

Molecules, 2019
Four novel xanthohumol (XN) cocrystals with pharmaceutically acceptable coformers, such as nicotinamide (NIC), glutarimide (GA), acetamide (AC), and caffeine (CF) in the 1:1 stoichiometry were obtained by the slow evaporation solution growth technique ...
Iwona Budziak, Marta Arczewska, Daniel M. Kamiński   +2 more
doaj   +1 more source

Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance [PDF]

, 2011
Cocrystals have been increasingly recognized as an attractive alternative delivery form for solid drug products. In this work, Raman spectroscopy, X-ray powder diffraction/X-ray crystallography, and differential scanning calorimetry have been used to ...
Aakeroy, Berry, Bettinetti, Bickley, Caira, Caira, Childs, Desiraju, El-Shahawy, Etter, Etter, Etter, Etter, H. G. M. Edwards, He, I. J. Scowen, Karki, Kauffman, Lemmerer, M. A. Elbagerma, Morissette, Myz, Nangia, Nichols, Oswald, Oswald, Rao, Rodriguez-Spong, Schantz, Sheikh, T. Munshi, Vishweshwar, Vishweshwar, Wenger, Weyna   +34 more
core   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

Halogen and hydrogen bonding in multicomponent crystals of tetrabromo-1H-benzotriazole [PDF]

, 2017
4,5,6,7-Tetrabromo-1H-benzotriazole (TBBT) is still considered a reference inhibitor of casein kinase II (CK2), a valuable target for anticancer therapy, even though the poor solubility in water of this active pharmaceutical ingredient (API) has ...
Baldrighi, Michele, Metrangolo, Pierangelo, Pilati, Tullio, Resnati, Giuseppe, Terraneo, Giancarlo   +4 more
core   +2 more sources