Results 101 to 110 of about 11,037 (206)
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
ChemistryOpen, 2019 The halogen bond has previously been explored as a versatile tool in crystal engineering and anion coordination chemistry, with mechanochemical synthetic techniques having been shown to provide convenient routes towards cocrystals. In an effort to expand
Vincent M. Morin +4 more
doaj +1 more source
Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
Pharmaceutics, 2019 The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid ...
Reynaldo Salas-Zúñiga +6 more
doaj +1 more source
Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies [PDF]
, 2016 YesHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT.
Aakeröy +57 more
core +1 more source
Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi
ChemMedChem, Volume 21, Issue 6, 27 March 2026.Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen +8 more
wiley +1 more source
Solvates, salts, and cocrystals : a proposal for a feasible classification system [PDF]
, 2016 The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has led to inconsistent definitions for cocrystals and for ...
De Gelder, R. +4 more
core +2 more sources
European Journal of Organic Chemistry, Volume 29, Issue 12, 23 March 2026.The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus +24 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2005 Cocrystals of 5-nitrouracil with solvent molecules, dioxane, pyridine, DMSO, formamide and ethanol as well as with piperazine, N, N'-dimethylpiperazine, 3-aminopyridine and diazabicyclo [2.2.2]octane obtained by deliberate inclusion, have been examined ...
Reji Thomas +3 more
doaj +1 more source
Crystals, 2020 Tuning and controlling the solid-state photophysical properties of organic luminophore are very important to develop next-generation organic luminescent materials.
Torvid Feiler +5 more
doaj +1 more source