Results 101 to 110 of about 16,055 (257)

Mechanochemical Preparations of Anion Coordinated Architectures Based on 3‐Iodoethynylpyridine and 3‐Iodoethynylbenzoic Acid

ChemistryOpen, 2019
The halogen bond has previously been explored as a versatile tool in crystal engineering and anion coordination chemistry, with mechanochemical synthetic techniques having been shown to provide convenient routes towards cocrystals. In an effort to expand
Vincent M. Morin, Dr. Patrick M. J. Szell, Estelle Caron‐Poulin, Dr. Bulat Gabidullin, Prof. Dr. David L. Bryce   +4 more
doaj   +1 more source

Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Pharmaceutics, 2019
The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid ...
Reynaldo Salas-Zúñiga, Christian Rodríguez-Ruiz, Herbert Höpfl, Hugo Morales-Rojas, Obdulia Sánchez-Guadarrama, Patricia Rodríguez-Cuamatzi, Dea Herrera-Ruiz   +6 more
doaj   +1 more source

Continuous manufacturing of high quality pharmaceutical cocrystals integrated with process analytical tools for in-line process control [PDF]

, 2016
A continuous manufacturing process for pharmaceutical indomethacin–saccharine cocrystals was achieved by extrusion processing with high throughput. Down-stream milling and blending of the extrudates was followed by feeding the formulated cocrystals in a ...
Chowdhry, Babur Z., Douroumis, Dennis, Halsey, Sheelagh A., Islam, Muhammad T., Moradiya, Hiren G., Scoutaris, Nikolaos   +5 more
core   +2 more sources

 Pharmaceutical Cocrystals a Patentable Composition - A Review [PDF]

, 2023
Ramadoss Karthikeyan, Haema Ganapathi, Vijayan Venugopal, Sakthiganapathi Meenatchi Sundaram, S Shanmuganathan, V. Velmurugan   +5 more
openalex   +1 more source

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Hydrogen bonding patterns in the cocrystals of 5-nitrouracil with several donor and acceptor molecules

Beilstein Journal of Organic Chemistry, 2005
Cocrystals of 5-nitrouracil with solvent molecules, dioxane, pyridine, DMSO, formamide and ethanol as well as with piperazine, N, N'-dimethylpiperazine, 3-aminopyridine and diazabicyclo [2.2.2]octane obtained by deliberate inclusion, have been examined ...
Reji Thomas, R. Srinivasa Gopalan, G. U. Kulkarni, C. N. R. Rao   +3 more
doaj   +1 more source

Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis

Molecules, 2019
Four novel xanthohumol (XN) cocrystals with pharmaceutically acceptable coformers, such as nicotinamide (NIC), glutarimide (GA), acetamide (AC), and caffeine (CF) in the 1:1 stoichiometry were obtained by the slow evaporation solution growth technique ...
Iwona Budziak, Marta Arczewska, Daniel M. Kamiński   +2 more
doaj   +1 more source

Cocrystallization of gliclazide with improved physicochemical properties

Future Journal of Pharmaceutical Sciences, 2021
Background Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble.
Shivarani Eesam, Jaswanth S. Bhandaru, Raghuram Rao Akkinepally, Ravi Kumar Bobbala   +3 more
doaj   +1 more source

Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies [PDF]

, 2016
YesHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT.
Aakeröy, Aitipamula, Aitipamula, Aitipamula, Aitipamula, Animesh Ghosh, Bag, Borba, Braga, C. Malla Reddy, Chadha, Chadha, Chadha, Chan, Clarke, Desiraju, Dolomanov, El-Gizawy, Fandaruff, Ghosh, Ghosh, Ghosh, Gonçalves, Gopi, Gwak, Hancock, Kadam, Khan, Krishna, Leuner, Li, Martins, Mureşan-Pop, Ni, Palatinus, Pires, Qiao, Rajewski, Ramesh Devarapalli, Rao Khandavilli, Rasenack, Remenar, Saha, Sanphui, Sanphui, Sarma, Serajuddin, Sheldrick, Subham Ranjan, Sudeshna Kundu, Swapna, Vangala, Vangala, Vasconcelos, Vasisht, Venu R. Vangala, Vyas, Wang   +57 more
core   +1 more source

Structural Basis of the Light‐Switchable Interaction between an Azobenzene Side Chain in a Biosynthetic Protein and α‐Cyclodextrin

ChemistryOpen, EarlyView.
X‐ray crystallographic analysis of super‐folder green fluorescent protein (sfGFP), a common reporter protein, displaying p‐(phenylazo)‐L‐phenylalanine (Pap) at amino acid position 39 on its surface in complex with α‐cyclodextrin (α‐CD) reveals an unexpected conformation of the photoswitchable side chain and illustrates its light‐dependent ...
Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Leonie Jarzinka, Arne Skerra   +4 more
wiley   +1 more source