Results 111 to 120 of about 16,055 (257)
Crystals, 2020 Tuning and controlling the solid-state photophysical properties of organic luminophore are very important to develop next-generation organic luminescent materials.
Torvid Feiler +5 more
doaj +1 more source
Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies [PDF]
, 2016 Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological ...
Douroumis, D. +2 more
core +1 more source
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Propellants, Explosives, Pyrotechnics, EarlyView.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Insight into inclusion complexation of indomethacin nicotinamide cocrystals [PDF]
The objective of this research was to investigate the feasibility of the interaction between indomethacin-nicotinamide cocrystals with β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the solid-state.
Ali, HRH, Saleem, IY, Tawfeek, HM
core +1 more source
The FEBS Journal, EarlyView.The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima +12 more
wiley +1 more source
Halogen and hydrogen bonding in multicomponent crystals of tetrabromo-1H-benzotriazole [PDF]
, 2017 4,5,6,7-Tetrabromo-1H-benzotriazole (TBBT) is still considered a reference inhibitor of casein kinase II (CK2), a valuable target for anticancer therapy, even though the poor solubility in water of this active pharmaceutical ingredient (API) has ...
Baldrighi, Michele +4 more
core +2 more sources
De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase
Plant Biotechnology Journal, EarlyView.ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He +7 more
wiley +1 more source
Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
doaj +1 more source