Results 111 to 120 of about 11,037 (206)

Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies [PDF]

, 2016
Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological ...
Douroumis, D., Lamprou, D. A., Ross, S. A.   +2 more
core   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Coformer Replacement as an Indicator for Thermodynamic Instability of Cocrystals: Competitive Transformation of Caffeine:Dicarboxylic Acid [PDF]

, 2016
yesThe thermodynamic stability of caffeine (CA) cocrystals with dicarboxylic acids (DAs) as coformers was investigated in the presence of a range of structurally related dicarboxylic acids (SRDs).
Alsirawan, M.H.D. Bashir, Kendrick, John, Leusen, Frank J.J., Paradkar, Anant R., Vangala, Venu R.   +4 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, Volume 600, Issue 6, Page 765-792, March 2026.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Insight into inclusion complexation of indomethacin nicotinamide cocrystals [PDF]

The objective of this research was to investigate the feasibility of the interaction between indomethacin-nicotinamide cocrystals with β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the solid-state.
Ali, HRH, Saleem, IY, Tawfeek, HM
core   +1 more source

Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties [PDF]

, 2014
YesPolymorphism of crystalline drugs is a common phenomenon. However, the number of reported polymorphic cocrystals is very limited. In this work, the synthesis and solid state characterisation of a polymorphic cocrystal composed of sulfadimidine (SD ...
Alhalaweh, Anne Marie Healy, Apperley, Babu, Bethune, Bhatt, Blagden, Caira, Caira, Caira, Cheary, Christine Grossjohann, Coelho, David, Dolores R. Serrano, Forbes, Friščić, Good, Grossjohann, Healy, Karki, Krzysztof J. Paluch, Lapidus, Le Bail, Liana Vella-Zarb, Lidia Tajber, Loureiro, Lover, Macrae, Miroshnyk, Murikipudi, Nehm, Owen I. Corrigan, Panagiotis Manesiotis, Peter O’Connell, Rietveld, Serrano Lopez, Tajber, Thomas McCabe, Vishweshwar, Wahl, Wahl, Wermuth   +42 more
core   +1 more source

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs [PDF]

, 2017
YesPolymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product.
Aitipamula, Aitipamula, Aitipamula, Alhalaweh, Anant Paradkar, Azizi, Bag, Bauer, Benjamin Whiteside, Bernstein, Buanz, Burger, Burger, Cassidy, Chow, Dhumal, Duggirala, Duggirala, Eddleston, Fleischman, Good, Grant, Gu, Hickey, Hilfiker, Hong, Jung, Karki, Li, Maeno, Mangin, McNamara, Niten Jadav, Pagire, Porter, Qiu, Rager, Ranjan, Remenar, Sarkar, Shan, Sheikh, Sudhir K. Pagire, Sun, Trask, Trask, Vangala, Vangala, Vangala, Variankaval, Venu R. Vangala, Vishwehwar   +51 more
core   +1 more source

Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies

Pharmaceutics, 2011
The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and ...
Karthik Nagapudi, Fernando Alvarez-Núñez, Robert Saw, Cesar Medina, Dominick Daurio   +4 more
doaj   +1 more source

Novel Charge-Transfer Materials via Cocrystallization of Planar Aromatic Donors and Spherical Polyoxometalate Acceptors [PDF]

, 2000
Spherical polyoxometalates (POMs) such as M6O192- and SiM12O404- (with M = Mo or W) and planar arene donors (anthracenes and pyrenes) can be cocrystallized (despite their structural incompatibility) by attaching a cationic “anchor” onto the arene which ...
Hubig, S. M., Kochi, Jay K., Lindeman, Sergey V., Maguères, P. Le, Peya, P.   +4 more
core   +1 more source