Results 61 to 70 of about 616,369 (340)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comparative Study on Codon Usage Patterns across Chloroplast Genomes of Eighteen Taraxacum Species

Horticulturae
This study investigates codon usage bias within the chloroplast genomes of 18 Taraxacum species, focusing on the base composition and various metrics including GC content, Relative Synonymous Codon Usage (RSCU), Effective Number of Codons (ENc), and GC3s.
Yang Yang, Xingliang Wang, Zhenjie Shi
doaj   +1 more source

First Draft Genome Assembly of the Malaysian Stingless Bee, Heterotrigona itama (Apidae, Meliponinae)

Data, 2020
The Malaysian stingless bee industry is hugely dependent on wild colonies. Nevertheless, the availability of new queens to establish new colonies is insufficient to meet the growing demand for hives in the industry.
Chien-Yeong Wee, Amin-Asyraf Tamizi, Nazrul-Hisham Nazaruddin, Siuk-Mun Ng, Jia-Shiun Khoo, Rosliza Jajuli   +5 more
doaj   +1 more source

Third-codon transversion rate-based _Nymphaea_ basal angiosperm phylogeny -- concordance with developmental evidence [PDF]

, 2007
Flowering plants (angiosperms) appeared on Earth rather suddenly approximately 130 million years ago and underwent a massive expansion in the subsequent 10-12 million years.
(Max) Zong-Ming Cheng, Gerald Tuskan, Timothy Tschaplinski, Xiaohan Yang, Xiaohan Yang   +4 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Converting nonsense codons into sense codons by targeted pseudouridylation [PDF]

Nature, 2011
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon. Here, we demonstrate that pseudouridylation (conversion of uridine into pseudouridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vitro and in vivo.
John, Karijolich, Yi-Tao, Yu
openaire   +2 more sources

Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. [PDF]

, 2019
BackgroundGeneral translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states.
A Battle, A Dana, A Kozomara, A Radhakrishnan, A Reyes, AG Hinnebusch, AG Hinnebusch, AO Subtelny, AV Pisarev, CDS Duncan, CJ Shoemaker, CL Simms, D Fell, D Ray, D Weinberg, DH Mathews, DR Cavener, DR Groebe, EM Novoa, F Sinturel, GL Chew, Guo-Liang Chew, GW Li, H Firczuk, H Gingold, H Gingold, H Guo, H Kacser, J Sponer, JD Blair, Jingyi Jessica Li, JJ Li, JJ Li, JJ Li, JT Cuperus, KA Cottrell, LD Fernades, M dos Reis, M Gonzalez-Porta, M Kozak, M Lynch, Mark Douglas Biggin, Mary K. Thompson, MF Princiotta, MF Rojas-Duran, MJ Liu, MW Jones-Rhoades, ND Sen, P Janich, P Shah, PN Borer, PY Hsu, R Lorenz, R Tunney, R Zhang, S Dvir, S Nakagawa, SA Lima, SJ Marygold, T Ben-Yehezkel, T Tuller, T Tuller, T von der Haar, T Xia, TG Johnstone, V Castelo-Szekely, V Presnyak, WL Noderer, Y Seol, Y Zarai, YV Svitkin, Z Bloom-Ackermann   +71 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Genes Translocated into the Plastid Inverted Repeat Show Decelerated Substitution Rates and Elevated GC Content. [PDF]

, 2016
Plant chloroplast genomes (plastomes) are characterized by an inverted repeat (IR) region and two larger single copy (SC) regions. Patterns of molecular evolution in the IR and SC regions differ, most notably by a reduced rate of nucleotide substitution ...
Kuo, Li-Yaung, Li, Fay-Wei, Pryer, Kathleen, Rothfels, Carl   +3 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source